NDUFS8 and CDH16

Data Source: HiPPIP (Novel)

		NDUFS8	CDH16
Name		NADH:ubiquinone oxidoreductase core subunit S8	cadherin 16
Structure			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex I	Plasma Membrane Membrane Basolateral Plasma Membrane Synapse Extracellular Exosome
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding	Calcium Ion Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Cell-cell Adhesion
Pathways		Respiratory electron transport Complex I biogenesis	None
Drugs		NADH	None
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome	None
GWAS		No GWAS studies recorded	HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 )
Novel Interactors		1 novel interactors: CDH16	7 novel interactors: ATP2A3 CDH5 GCM1 MRPL52 NDUFS8 NQO1 TUBB
Interacting Genes		2 interacting genes: GEM UBC	2 interacting genes: CTNNB1 G6PC1
Entrez ID		4728	1014
HPRD ID		03683	11929
Ensembl ID		ENSG00000110717	ENSG00000166589
Uniprot IDs		O00217	O75309
PDB IDs		5XTB 5XTD 5XTH 5XTI	Not available
GO Terms Enriched among Interactors		None	Response To Caloric Restriction Transmembrane Transporter Binding Catenin Complex Homeostatic Process Calcium-dependent ATPase Activity Calcium Ion Transport From Cytosol To Endoplasmic Reticulum Regulation Of Endothelial Cell Differentiation Cell Periphery Cell-cell Junction Assembly Protein Phosphatase Binding Cell-cell Adhesion Mediated By Cadherin Adherens Junction Organization Bicellular Tight Junction Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Mesenchymal Stem Cell Differentiation Oviduct Development Positive Regulation Of Determination Of Dorsal Identity Negative Regulation Of Mitotic Cell Cycle, Embryonic Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Beta-catenin-ICAT Complex Negative Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Acinar Cell Differentiation Positive Regulation Of Proteoglycan Biosynthetic Process Fungiform Papilla Formation Negative Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Beta-catenin-TCF7L2 Complex Glial Cell Fate Determination Astrocyte-dopaminergic Neuron Signaling Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Metanephros Morphogenesis Trachea Morphogenesis Regulation Of Mitotic Cell Cycle, Embryonic Renal Inner Medulla Development Scrib-APC-beta-catenin Complex Regulation Of Centriole-centriole Cohesion Renal Outer Medulla Development Renal Vesicle Formation Embryonic Skeletal Limb Joint Morphogenesis Glial Cell-neuron Signaling Lung Induction Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Positive Regulation Of Branching Involved In Lung Morphogenesis Neural Plate Development Catenin-TCF7L2 Complex NADH Dehydrogenase (quinone) (non-electrogenic) Activity NADPH Dehydrogenase (quinone) Activity NAD(P)H Dehydrogenase (quinone) Activity Response To Resveratrol Glucose-6-phosphatase Activity Astrocyte Fate Commitment