NDUFS8

Name	NADH:ubiquinone oxidoreductase core subunit S8
Structure
Novel Interactors	1 novel interactors: CDH16
Interactors	2 interactors: GEM UBC
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Respiratory Chain Complex I
	Molecular Function	NADH Dehydrogenase Activity Protein Binding NADH Dehydrogenase (ubiquinone) Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Metal Ion Binding Iron-sulfur Cluster Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Aerobic Respiration Mitochondrial Respiratory Chain Complex I Assembly Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport
Pathways	Respiratory electron transport Complex I biogenesis
Drugs	NADH
Diseases	Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS	No GWAS studies recorded
Entrez ID	4728
HPRD ID	03683
Ensembl ID	ENSG00000110717
Uniprot IDs	O00217
PDB IDs	5XTB 5XTD 5XTH 5XTI