NBL1 and LRIG1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NBL1	LRIG1
Description		NBL1, DAN family BMP antagonist	leucine rich repeats and immunoglobulin like domains 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane Membrane
	Molecular Function	Protein Binding Morphogen Activity BMP Binding Identical Protein Binding Receptor Ligand Activity	Protein Binding Signaling Receptor Activity
	Biological Process	Signal Transduction Nervous System Development Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Positive Regulation Of Neuron Differentiation Determination Of Dorsal Identity Neuron Projection Morphogenesis Negative Regulation Of Monocyte Chemotaxis	Sensory Perception Of Sound Hair Cycle Process Otolith Morphogenesis Innervation
Pathways			Signaling by EGFR Negative regulation of MET activity Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Bronchopulmonary dysplasia in preterm infants ( 30113228) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Serum thyroid-stimulating hormone levels ( 24852370) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adverse response to chemotherapy (neutropenia/leucopenia) (all platinum-based drugs) ( 23648065) Adverse response to chemotherapy (neutropenia/leucopenia) (carboplatin) ( 23648065) Antibody status in Tripanosoma cruzi seropositivity ( 24324551) Atrial fibrillation ( 30061737 29892015) Birth weight ( 31043758) Blood urea nitrogen levels ( 29403010) Carotid intima media thickness ( 21909108) Chronic kidney disease ( 29124443) Colorectal cancer ( 26151821) Colorectal cancer or advanced adenoma ( 30510241) Creatinine levels ( 29124443) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 29124443) Hyperuricemia ( 29124443) Intraocular pressure ( 30054594) Iron status biomarkers (iron levels) ( 33536631) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Non-glioblastoma glioma ( 28346443) Orofacial clefts ( 33137956) Pulse pressure ( 27841878) QRS duration ( 27659466 27577874 21076409) Red cell distribution width ( 32888494) Refractive error ( 32231278) Renal function-related traits (BUN) ( 22797727) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Retinal detachment or retinal break ( 31816047) Serum uric acid levels ( 29124443) Systolic blood pressure ( 27841878) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		14 interacting genes: BAG6 DPEP2NB HPCAL1 KRTAP11-1 LRIG1 MEOX2 MRPL12 NCALD NCS1 PLA2G2F SLPI UBQLN1 UBQLN2 ZMIZ2	5 interacting genes: CBL GLRX3 MICOS10-NBL1 NBL1 ZBTB16
Entrez ID		4681	26018
HPRD ID		09001	10057
Ensembl ID		ENSG00000158747	ENSG00000144749
Uniprot IDs		A0A087WTY6 P41271	Q96JA1
PDB IDs		4X1J 4YU8	4U7L 4U7M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Calcium Ion Binding	Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction BMP Binding Negative Regulation Of Leukocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Mononuclear Cell Migration Regionalization Negative Regulation Of Chemotaxis Negative Regulation Of Leukocyte Migration Pattern Specification Process Maintenance Of Protein Location Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Maintenance Of Location Positive Regulation Of Neuron Differentiation Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Identical Protein Binding Receptor Ligand Activity Type 2 Angiotensin Receptor Binding Regulation Of Mononuclear Cell Migration Male Germ-line Stem Cell Asymmetric Division Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Rap Protein Signal Transduction Regulation Of Neuron Differentiation Positive Regulation Of Cell Differentiation Germ-line Stem Cell Division Positive Regulation Of NK T Cell Differentiation Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Chemotaxis Ubiquitin-dependent Endocytosis Regulation Of Leukocyte Migration Regulation Of NK T Cell Differentiation System Development Flotillin Complex Phosphatidylinositol 3-kinase Regulatory Subunit Binding Cell Projection Morphogenesis Neuron Projection Morphogenesis Ossification Involved In Bone Maturation Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway [2Fe-2S] Cluster Assembly Iron-sulfur Cluster Assembly Complex Negative Regulation Of Cell Migration Regulation Of Cellular Response To Growth Factor Stimulus Mesonephros Development
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