NBL1 and DPEP2NB

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		NBL1	DPEP2NB
Description		NBL1, DAN family BMP antagonist	DPEP2 neighbor
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space
	Molecular Function	Protein Binding Morphogen Activity BMP Binding Identical Protein Binding Receptor Ligand Activity	Protein Binding
	Biological Process	Signal Transduction Nervous System Development Neuron Differentiation Negative Regulation Of BMP Signaling Pathway Sequestering Of Extracellular Ligand From Receptor Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Positive Regulation Of Neuron Differentiation Determination Of Dorsal Identity Neuron Projection Morphogenesis Negative Regulation Of Monocyte Chemotaxis
Pathways
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Bronchopulmonary dysplasia in preterm infants ( 30113228) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Lymphocyte count ( 32888494) Serum thyroid-stimulating hormone levels ( 24852370) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		14 interacting genes: BAG6 DPEP2NB HPCAL1 KRTAP11-1 LRIG1 MEOX2 MRPL12 NCALD NCS1 PLA2G2F SLPI UBQLN1 UBQLN2 ZMIZ2	9 interacting genes: ARMC7 CABP2 COL8A1 FRS3 KANK2 MICOS10-NBL1 NBL1 TRAF4 ZNF410
Entrez ID		4681	100131303
HPRD ID		09001
Ensembl ID		ENSG00000158747	ENSG00000263201
Uniprot IDs		A0A087WTY6 P41271	A0A0U1RQF7
PDB IDs		4X1J 4YU8
Enriched GO Terms of Interacting Partners?		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Negative Regulation Of Store-operated Calcium Channel Activity Calcium Ion Binding	Sequestering Of BMP In Extracellular Matrix Sequestering Of BMP From Receptor Via BMP Binding Determination Of Dorsal Identity Morphogen Activity Negative Regulation Of Monocyte Chemotaxis Sequestering Of Extracellular Ligand From Receptor Extracellular Negative Regulation Of Signal Transduction BMP Binding Negative Regulation Of Leukocyte Chemotaxis Regulation Of Monocyte Chemotaxis Negative Regulation Of Mononuclear Cell Migration Negative Regulation Of Chemotaxis Negative Regulation Of Leukocyte Migration Maintenance Of Protein Location Dorsal/ventral Pattern Formation Negative Regulation Of BMP Signaling Pathway Maintenance Of Location Collagen Type VIII Trimer Positive Regulation Of Neuron Differentiation Negative Regulation Of Vitamin D Receptor Signaling Pathway Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Receptor Ligand Activity Regulation Of Mononuclear Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Podocyte Cell Migration Regulation Of Neuron Differentiation
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