MTX1 and MTX2

Number of citations: 0 (PubMedID 10381257)
Data Source: HPRD (two hybrid, in vitro)

		MTX1	MTX2
Name		metaxin 1	metaxin 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	SAM Complex Mitochondrion Mitochondrial Outer Membrane Membrane MIB Complex	SAM Complex Nucleolus Mitochondrion Mitochondrial Outer Membrane Membrane MIB Complex
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Mitochondrion Organization Inner Mitochondrial Membrane Organization Lactation Protein Transport Protein Insertion Into Mitochondrial Outer Membrane	Mitochondrial Transport Mitochondrion Organization Inner Mitochondrial Membrane Organization Protein Transport Protein Insertion Into Mitochondrial Outer Membrane
Pathways		Mitochondrial protein import Cristae formation RAC2 GTPase cycle	Mitochondrial protein import Cristae formation
GWAS		Blood urea nitrogen levels ( 31152163 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cancer ( 27197191 ) Cancer (pleiotropy) ( 27197191 ) Cortical surface area (min-P) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Cortical thickness (min-P) ( 32665545 ) Cortical thickness (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Estimated glomerular filtration rate ( 31451708 31015462 ) Gastric adenocarcinoma (histologically verified) ( 26098866 ) Gastric cancer ( 26098866 ) General risk tolerance (MTAG) ( 30643258 ) Gout ( 33832965 ) Hematocrit ( 27863252 32888494 ) Hemoglobin ( 32888494 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Inflammatory bowel disease ( 28067908 ) Low density lipoprotein cholesterol levels ( 32154731 ) Red blood cell count ( 27863252 32888494 ) Renal function-related traits (BUN) ( 22797727 ) Serum cancer antigen 15.3 levels ( 31666285 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Urate levels ( 31578528 ) Urea levels ( 28270201 )	Blond vs. brown/black hair color ( 30531825 ) Blood urea nitrogen levels ( 31152163 ) Chin dimples ( 27182965 ) Chronic kidney disease ( 31152163 ) Estimated glomerular filtration rate in non-diabetics ( 31451708 ) Eye morphology ( 29921221 ) Male-pattern baldness ( 27182965 28196072 ) Monobrow ( 27182965 ) Upper eyelid morphology ( 29921221 ) Urate levels ( 31578528 )
Novel Interactors		None recorded	2 novel interactors: EXOSC2 HSP90AB1
Interacting Genes		7 interacting genes: A1BG CLN8 GABARAP MAP1LC3A MAP1LC3B MTX2 TOMM40	6 interacting genes: C1QTNF2 KASH5 MTX1 RHOH TADA2A UBQLN2
Entrez ID		4580	10651
HPRD ID		11861	09777
Ensembl ID		ENSG00000173171	ENSG00000128654
Uniprot IDs		Q13505	O75431
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Vacuole Organization Autophagosome Maturation Autophagosome Membrane Mitophagy Autophagy Of Mitochondrion Autophagosome Ceramide Binding Autophagosome Assembly Autophagosome Organization Mitochondrial Membrane Organization Protein Insertion Into Mitochondrial Outer Membrane Phospholipid Binding Protein-containing Complex Disassembly Macroautophagy Cellular Response To Starvation Organelle Organization Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Response To Starvation Mitochondrion Organization Microtubule Binding Cellular Response To Nutrient Levels Endomembrane System Organelle Membrane Autophagy Ubiquitin Protein Ligase Binding Microtubule Protein Insertion Into Membrane Establishment Of Protein Localization To Mitochondrion Response To Nutrient Levels Somatic Motor Neuron Differentiation Glutamate Reuptake Retinal Rod Cell Apoptotic Process Axoneme Positive Regulation Of Protein K48-linked Ubiquitination Cellular Response To Oxygen-glucose Deprivation Membrane Organization Mitochondrion Organelle Assembly Porin Activity Regulation Of Protein K48-linked Ubiquitination Retinal Cell Apoptotic Process Protein Targeting TOM Complex Mitochondrial Outer Membrane Response To Iron(II) Ion Establishment Of Protein Localization To Membrane Mitochondrial Outer Membrane Translocase Complex	None