BECN2 and CNR1

Number of citations: 31 (PubMedID 23954414)
Data Source: BioGRID (two hybrid)

		BECN2	CNR1
Name		beclin 2	cannabinoid receptor 1
Structure
GO Annotations	Cellular Component	Phagophore Assembly Site Cytoplasm Phosphatidylinositol 3-kinase Complex, Class III, Type I Phosphatidylinositol 3-kinase Complex, Class III, Type II	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Plasma Membrane Actin Cytoskeleton Membrane Axon Growth Cone Presynaptic Membrane Cell Projection Membrane Raft Synapse Presynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity Phosphatidylinositol 3-kinase Binding Protein-containing Complex Binding	G Protein-coupled Receptor Activity Cannabinoid Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Autophagosome Assembly Mitophagy Autophagy Cellular Response To Nitrogen Starvation Endosome To Lysosome Transport Receptor Catabolic Process Glucose Homeostasis Late Endosome To Vacuole Transport G Protein-coupled Receptor Catabolic Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Axonal Fasciculation Cannabinoid Signaling Pathway Glucose Homeostasis Retrograde Trans-synaptic Signaling By Endocannabinoid Regulation Of Presynaptic Cytosolic Calcium Ion Concentration
Pathways		None	Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events
Drugs		None	Dronabinol Nabilone Ricinoleic acid SLV319 V24343 AVE-1625 Rimonabant Cannabidiol Propacetamol Otenabant Tetrahydrocannabivarin Medical Cannabis Nabiximols
GWAS		No GWAS studies recorded	Depression in smokers ( 30219690 ) Gut microbiota (functional units) ( 27694959 )
Interacting Genes		3 interacting genes: ADRB2 CNR1 TP53INP2	10 interacting genes: ADORA2A BECN2 GNA15 GNAI1 GNAI2 GNAI3 HCRTR1 MET NSRP1 SSTR5
Entrez ID		441925	1268
HPRD ID		Not available	00259
Ensembl ID		ENSG00000196289	ENSG00000118432
Uniprot IDs		A8MW95	P21554 S5TLS4 V5KA96
PDB IDs		5K7B 5K9L 8GT9 8GU7	1LVQ 1LVR 2B0Y 2KOE 2MZ2 2MZ3 2MZA 5TGZ 5U09 5XR8 5XRA 6KPG 6KQI 6N4B 7FEE 7V3Z 7WV9 8GAG 8GHV 8IKG 8IKH 8K8J 8WRZ 8WU1 9B54 9B65 9B9Y 9B9Z 9BA0 9ERX
GO Terms Enriched among Interactors		Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Anatomical Structure Homeostasis Tissue Homeostasis Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Beta-adrenergic Receptor Activity Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Homeostatic Process Positive Regulation Of Mini Excitatory Postsynaptic Potential Beta2-adrenergic Receptor Activity Cannabinoid Receptor Activity Cannabinoid Signaling Pathway Retrograde Trans-synaptic Signaling By Endocannabinoid Response To Psychosocial Stress Norepinephrine Binding Positive Regulation Of Lipophagy AMPA Selective Glutamate Receptor Signaling Pathway Positive Regulation Of Autophagosome Maturation Heat Generation G Protein-coupled Receptor Activity Adrenergic Receptor Activity Diet Induced Thermogenesis Adenylate Cyclase Binding Negative Regulation Of Smooth Muscle Contraction Negative Regulation Of Multicellular Organism Growth Multicellular Organismal-level Homeostasis Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Autophagosome Maturation Positive Regulation Of CAMP/PKA Signal Transduction Negative Regulation Of Muscle Contraction Neuronal Dense Core Vesicle Adrenergic Receptor Signaling Pathway Negative Regulation Of Systemic Arterial Blood Pressure Neuron Projection Fasciculation Axonal Fasciculation Adaptive Thermogenesis Bone Resorption Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Brown Fat Cell Differentiation Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential G Protein-coupled Receptor Signaling Pathway Temperature Homeostasis Positive Regulation Of Protein-containing Complex Disassembly Response To Cold Ligand-gated Ion Channel Signaling Pathway Positive Regulation Of Bone Mineralization Regulation Of CAMP/PKA Signal Transduction Potassium Channel Regulator Activity	Guanyl Nucleotide Binding G-protein Beta/gamma-subunit Complex Binding Heterotrimeric G-protein Complex G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Binding Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Adenosine Receptor Signaling Pathway Positive Regulation Of Urine Volume Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity GTPase Activity Neuropeptide Signaling Pathway GTP Binding Regulation Of Urine Volume G Protein-coupled Acetylcholine Receptor Signaling Pathway Purinergic Nucleotide Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Midbody Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Secretion By Cell Acetylcholine Receptor Signaling Pathway Regulation Of Secretion Postsynaptic Signal Transduction Regulation Of Protein Secretion Signal Transduction Regulation Of ERK1 And ERK2 Cascade Excitatory Postsynaptic Potential Hepatocyte Growth Factor Receptor Activity Plasma Membrane Ciliary Basal Body Regulation Of Cell Communication Regulation Of Signaling GDP Binding Feeding Behavior G Protein-coupled Receptor Activity Orexin Receptor Activity G Protein-coupled Receptor Catabolic Process Regulation Of Postsynaptic Membrane Potential Regulation Of Protein Transport Positive Regulation Of Acetylcholine Secretion, Neurotransmission Nucleotide Binding D2 Dopamine Receptor Binding Positive Regulation Of Relaxation Of Smooth Muscle G Protein-coupled Serotonin Receptor Binding Cell Division Positive Regulation Of MAPK Cascade Regulation Of Acetylcholine Secretion, Neurotransmission Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway