NR3C2 and PROX1

Number of citations of the paper that reports this interaction (PMID 15604093)
36

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NR3C2	PROX1
Gene Name		nuclear receptor subfamily 3, group C, member 2	prospero homeobox 1
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Membrane Receptor Complex	Nucleus Cytoplasm
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Core Promoter Sequence-specific DNA Binding DNA Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Ligand-dependent Nuclear Receptor Binding Transcription Regulatory Region DNA Binding DBD Domain Binding LBD Domain Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Steroid Hormone Mediated Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Cell Fate Determination Kidney Development Liver Development Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Lens Development In Camera-type Eye Hepatocyte Cell Migration Transcription From RNA Polymerase II Promoter Brain Development Circadian Rhythm Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Gene Expression Positive Regulation Of Endothelial Cell Migration Dorsal Spinal Cord Development Dentate Gyrus Development Cerebellar Granule Cell Differentiation Neural Tube Development Skeletal Muscle Thin Filament Assembly Lung Development Olfactory Placode Formation Pancreas Development Response To Nutrient Levels Regulation Of Circadian Rhythm Otic Placode Formation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Negative Regulation Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Optic Placode Formation Involved In Camera-type Eye Formation Venous Blood Vessel Morphogenesis Ventricular Cardiac Myofibril Assembly Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Retina Morphogenesis In Camera-type Eye Embryonic Retina Morphogenesis In Camera-type Eye Endocardium Formation Positive Regulation Of Sarcomere Organization Ventricular Septum Morphogenesis Aorta Smooth Muscle Tissue Morphogenesis Positive Regulation Of Heart Growth Lymphatic Endothelial Cell Differentiation Regulation Of Transcription Involved In Lymphatic Endothelial Cell Fate Commitment Branching Involved In Pancreas Morphogenesis Lens Fiber Cell Morphogenesis Hepatocyte Differentiation Negative Regulation Of Bile Acid Biosynthetic Process Hepatocyte Proliferation Acinar Cell Differentiation Neuronal Stem Cell Maintenance Positive Regulation Of Cell Cycle Checkpoint Positive Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Forebrain Neuron Differentiation
Pathways
Drugs		Nimodipine Progesterone Spironolactone Fluticasone Propionate Fludrocortisone Eplerenone Felodipine Desoxycorticosterone Pivalate Drospirenone Aldosterone (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE
Diseases
GWAS		Biochemical measures ( 19260141) Corneal structure ( 23291589) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906)	Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HIV-1 progression ( 20064070) Obesity ( 23818313)
Protein-Protein Interactions		19 interactors: ACSL1 ACTA1 ACTG1 AR EIF3I FKBP4 HSP90AA1 HSPA4 NR3C1 PIAS1 PIAS3 PROX1 PTGES3 RABAC1 RXRA SRC SUMO1 TRIM24 UBE2I	17 interactors: CREBBP CTBP2 EP300 ESRRA ESRRG GIT2 HNF4A IRF4 LBH NR3C2 NR5A1 NR5A2 PAX6 PPARD RORA SMAD3 ZBTB3
Entrez ID		4306	5629
HPRD ID		02991	03330
Ensembl ID		ENSG00000151623	ENSG00000117707
Uniprot IDs		B0ZBF6 P08235	Q92786
PDB IDs		1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG	2LMD
Enriched GO Terms of Interacting Partners?		Intracellular Steroid Hormone Receptor Signaling Pathway Protein Sumoylation Intracellular Receptor Signaling Pathway Cellular Component Assembly Response To Organic Substance Cellular Response To Steroid Hormone Stimulus Response To Hormone Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Steroid Hormone Gland Development Actomyosin Structure Organization Regulation Of Cellular Response To Heat Response To Lipid Response To Organic Cyclic Compound Androgen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Hormone-mediated Signaling Pathway Response To Stimulus Cellular Response To Hormone Stimulus Protein Import Into Mitochondrial Outer Membrane Cellular Macromolecular Complex Assembly Skeletal Muscle Thin Filament Assembly Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Skeletal Myofibril Assembly Negative Regulation Of RNA Biosynthetic Process Cellular Response To Lipid Cellular Response To Heat Positive Regulation Of Protein Metabolic Process Prostate Gland Development Striated Muscle Cell Differentiation Myofibril Assembly Organelle Organization Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Peptidyl-lysine Modification Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Sumoylation Chaperone-mediated Protein Complex Assembly Peptidyl-amino Acid Modification Steroid Hormone Mediated Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation	Transcription Initiation From RNA Polymerase II Promoter DNA-templated Transcription, Initiation Transcription, DNA-templated Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription, DNA-templated RNA Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Hormone-mediated Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter RNA Metabolic Process Gene Expression Cellular Macromolecule Biosynthetic Process Cellular Response To Organic Cyclic Compound Macromolecule Biosynthetic Process Cellular Response To Lipid Regulation Of Transcription From RNA Polymerase II Promoter Response To Steroid Hormone Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Response To Lipid Intracellular Receptor Signaling Pathway Cellular Response To Hormone Stimulus Nucleobase-containing Compound Metabolic Process Response To Organic Cyclic Compound Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Response To Hormone Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Organic Substance Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Response To Organic Substance Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Response To Oxygen Levels Signal Transduction Involved In Regulation Of Gene Expression N-terminal Peptidyl-lysine Acetylation Response To Hypoxia Signal Transduction
Tagcloud ?		11beta 11betahsd1 a3669g abcb1 adjustments bcl1 cassette cognitive cs cushing educational gc glucocorticoid hydroxysteroid i180v impairments interquartile mineralocorticoid neuropsychological nr3c1 participated polymorphisms prereceptor reading remission rs1045642 rs11119328 speed working	allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole
Tagcloud (Difference) ?		11beta 11betahsd1 a3669g abcb1 adjustments bcl1 cassette cognitive cs cushing educational gc glucocorticoid hydroxysteroid i180v impairments interquartile mineralocorticoid neuropsychological nr3c1 participated polymorphisms prereceptor reading remission rs1045642 rs11119328 speed working	allowed anatomical breakthrough decalcified describes dimensional endolymphatic epithelia gfp labeling lymphatic mitochondria mount organs parts pluripotency portion progenitor ribosome rich sac sectioning similarity surrounding technical techniques vasculature vessels whole
Tagcloud (Intersection) ?