NR3C2 and ACSL1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		NR3C2	ACSL1
Name		nuclear receptor subfamily 3 group C member 2	acyl-CoA synthetase long chain family member 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Receptor Complex	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Lipid Binding TBP-class Protein Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Ligase Activity Protein Serine/threonine Kinase Activator Activity Arachidonate-CoA Ligase Activity Phytanate-CoA Ligase Activity Pristanate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Oleoyl-CoA Ligase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Signal Transduction Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Cellular Response To Hormone Stimulus Response To Lipid Positive Regulation Of Non-canonical NF-kappaB Signal Transduction	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Nutrient Lipid Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Fatty Acid Transport Triglyceride Biosynthetic Process Adiponectin-activated Signaling Pathway Response To Oleic Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Xenobiotic Catabolic Process Linoleic Acid Metabolic Process Long-chain Fatty Acid Import Into Cell Positive Regulation Of Cold-induced Thermogenesis
Pathways		HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand SUMOylation of intracellular receptors	PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Nimodipine Progesterone Spironolactone Fluticasone propionate Testosterone Fludrocortisone Eplerenone Clobetasol propionate Felodipine Desoxycorticosterone pivalate Drospirenone Stanolone Metribolone Aldosterone Corticosterone Desoxycorticosterone acetate Fluticasone furoate Fluticasone Testosterone cypionate Testosterone enanthate Stanolone acetate Finerenone	Adenosine phosphate ATP
Diseases		Hypertension exacerbated in pregnancy Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)	None
GWAS		Alzheimer disease and age of onset ( 26830138 ) Amyotrophic lateral sclerosis (sporadic) ( 24529757 ) Benign childhood epilepsy with centro-temporal spikes ( 32580138 ) Biochemical measures ( 19260141 ) Blond vs. brown/black hair color ( 30531825 ) Central corneal thickness ( 32528159 29760442 ) Corneal structure ( 23291589 ) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Hippocampal volume ( 31530798 ) Hypothyroidism ( 27182965 ) Lymphocyte count ( 32888494 ) Lymphocyte percentage of white cells ( 32888494 ) Microalbuminuria ( 31511532 ) Neutrophil percentage of white cells ( 32888494 ) Plasma thyroid-stimulating hormone levels ( 28333968 ) Platelet distribution width ( 32888494 ) Platelet reactivity in response to clopidogrel treatment ( 32472697 ) Subcutaneous adipose tissue ( 22589738 ) Thyroid function ( 22494929 ) Thyroid hormone levels ( 23408906 ) Thyroid stimulating hormone levels ( 32769997 25743335 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31630189 31511532 ) Vestibular neuritis ( 30079052 )	Fasting glucose ( 34059833 ) Fulminant type 1 diabetes ( 30552108 ) Mean platelet volume ( 32888494 ) Neuroblastoma or malignant cutaneous melanoma ( 31605138 ) Night sleep phenotypes ( 27126917 ) Type 2 diabetes ( 28566273 30054458 30297969 )
Interacting Genes		20 interacting genes: ACSL1 ACTA1 ACTG1 AR CASP8AP2 FKBP4 HSP90AA1 HSPA4 NCOA1 NR3C1 PIAS1 PIAS3 PROX1 PSMC5 PTGES3 RABAC1 RXRA SUMO1 TRIM24 UBE2I	2 interacting genes: CEBPA NR3C2
Entrez ID		4306	2180
HPRD ID		02991	01068
Ensembl ID		ENSG00000151623	ENSG00000151726
Uniprot IDs		B0ZBF6 P08235	A8K9T3 B4E0R0 E7EPM6 P33121
PDB IDs		1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG 4PF3 4TNT 4UDA 4UDB 5HCV 5L7E 5L7G 5L7H 5MWP 5MWY 6GEV 6GG8 6GGG 6L88	Not available
GO Terms Enriched among Interactors		Negative Regulation Of DNA-templated Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Negative Regulation Of RNA Biosynthetic Process Hormone-mediated Signaling Pathway Presynaptic Cytosol Postsynaptic Cytosol Negative Regulation Of RNA Metabolic Process Nuclear Receptor-mediated Signaling Pathway Positive Regulation Of Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Estrogen Response Element Binding Protein Sumoylation Positive Regulation Of Macromolecule Metabolic Process Nucleoplasm Transcription Factor Binding SUMO Transferase Activity Regulation Of Macromolecule Biosynthetic Process Chaperone-mediated Protein Complex Assembly Nucleobase-containing Compound Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Biosynthetic Process Cytoplasm Negative Regulation Of Transcription By RNA Polymerase II PML Body DNA Binding Domain Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Small Protein Activating Enzyme Binding Chromatin Nucleus Skeletal Muscle Thin Filament Assembly Transcription By RNA Polymerase II Telomerase Holoenzyme Complex Assembly Nuclear Receptor Binding Regulation Of Thyroid Hormone Receptor Signaling Pathway LBD Domain Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nuclear Receptor Activity Negative Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Response To Estrogen Regulation Of Vitamin D Receptor Signaling Pathway Cytosol	RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Sequence-specific DNA Binding Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion CHOP-C/EBP Complex HMG Box Domain Binding Response To Phenylpropanoid Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway DNA-binding Transcription Factor Activity White Fat Cell Proliferation STAT Family Protein Binding Response To Hormone Osteoblast Development Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation Estrogen Response Element Binding Response To Lipid Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Negative Regulation Of Stem Cell Proliferation Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation TBP-class Protein Binding Steroid Binding Nuclear Steroid Receptor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Integrated Stress Response Signaling Acute-phase Response Macrophage Differentiation Response To Dexamethasone Nuclear Receptor Activity Animal Organ Regeneration Regulation Of Macrophage Activation Inner Ear Development Cellular Response To Xenobiotic Stimulus Acute Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Fat Cell Differentiation