NR3C2 and ACSL1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		NR3C2	ACSL1
Gene Name		nuclear receptor subfamily 3, group C, member 2	acyl-CoA synthetase long-chain family member 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Endoplasmic Reticulum Membrane Receptor Complex	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Steroid Binding Protein Binding Zinc Ion Binding Sequence-specific DNA Binding	Long-chain Fatty Acid-CoA Ligase Activity ATP Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Gene Expression Steroid Hormone Mediated Signaling Pathway	Long-chain Fatty Acid Metabolic Process Response To Nutrient Lipid Biosynthetic Process Response To Organic Cyclic Compound Triglyceride Biosynthetic Process Adiponectin-activated Signaling Pathway Unsaturated Fatty Acid Metabolic Process Response To Oleic Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Alpha-linolenic Acid Metabolic Process Xenobiotic Catabolic Process Response To Drug Linoleic Acid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Long-chain Fatty Acid Import Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways			PPARA activates gene expression Fatty Acyl-CoA Biosynthesis Fatty acid, triacylglycerol, and ketone body metabolism alpha-linolenic acid (ALA) metabolism Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Linoleic acid (LA) metabolism Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Triglyceride Biosynthesis Synthesis of very long-chain fatty acyl-CoAs
Drugs		Nimodipine Progesterone Spironolactone Fluticasone Propionate Fludrocortisone Eplerenone Felodipine Desoxycorticosterone Pivalate Drospirenone Aldosterone (11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE	Adenosine monophosphate Adenosine triphosphate
Diseases
GWAS		Biochemical measures ( 19260141) Corneal structure ( 23291589) Subcutaneous adipose tissue ( 22589738) Thyroid function ( 22494929) Thyroid hormone levels ( 23408906)
Protein-Protein Interactions		19 interactors: ACSL1 ACTA1 ACTG1 AR EIF3I FKBP4 HSP90AA1 HSPA4 NR3C1 PIAS1 PIAS3 PROX1 PTGES3 RABAC1 RXRA SRC SUMO1 TRIM24 UBE2I	1 interactors: NR3C2
Entrez ID		4306	2180
HPRD ID		02991	01068
Ensembl ID		ENSG00000151623	ENSG00000151726
Uniprot IDs		B0ZBF6 P08235	B7Z452 E7EPM6 P33121
PDB IDs		1Y9R 1YA3 2A3I 2AA2 2AA5 2AA6 2AA7 2AAX 2AB2 2ABI 2OAX 3VHU 3VHV 3WFF 3WFG
Enriched GO Terms of Interacting Partners?		Intracellular Steroid Hormone Receptor Signaling Pathway Protein Sumoylation Intracellular Receptor Signaling Pathway Cellular Component Assembly Response To Organic Substance Cellular Response To Steroid Hormone Stimulus Response To Hormone Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Response To Steroid Hormone Gland Development Actomyosin Structure Organization Regulation Of Cellular Response To Heat Response To Lipid Response To Organic Cyclic Compound Androgen Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Hormone-mediated Signaling Pathway Response To Stimulus Cellular Response To Hormone Stimulus Protein Import Into Mitochondrial Outer Membrane Cellular Macromolecular Complex Assembly Skeletal Muscle Thin Filament Assembly Positive Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Cellular Response To Organic Cyclic Compound Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Nucleic Acid-templated Transcription Skeletal Myofibril Assembly Negative Regulation Of RNA Biosynthetic Process Cellular Response To Lipid Cellular Response To Heat Positive Regulation Of Protein Metabolic Process Prostate Gland Development Striated Muscle Cell Differentiation Myofibril Assembly Organelle Organization Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Cellular Response To Organic Substance Peptidyl-lysine Modification Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Sumoylation Chaperone-mediated Protein Complex Assembly Peptidyl-amino Acid Modification Steroid Hormone Mediated Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Macromolecule Biosynthetic Process Protein Modification By Small Protein Conjugation	Cellular Sodium Ion Homeostasis Sodium Ion Homeostasis Excretion
Tagcloud ?		11beta 11betahsd1 a3669g abcb1 adjustments bcl1 cassette cognitive cs cushing educational gc glucocorticoid hydroxysteroid i180v impairments interquartile mineralocorticoid neuropsychological nr3c1 participated polymorphisms prereceptor reading remission rs1045642 rs11119328 speed working	2a adenovirus atf6 atgl augmented cardiomyocyte channeling chop create creation droplets eif2a esterified explored fatty grp78 incubated inefficient lipid lipids nefa neutral oleate palmitate ppargamma protects storage stored upregulation
Tagcloud (Difference) ?		11beta 11betahsd1 a3669g abcb1 adjustments bcl1 cassette cognitive cs cushing educational gc glucocorticoid hydroxysteroid i180v impairments interquartile mineralocorticoid neuropsychological nr3c1 participated polymorphisms prereceptor reading remission rs1045642 rs11119328 speed working	2a adenovirus atf6 atgl augmented cardiomyocyte channeling chop create creation droplets eif2a esterified explored fatty grp78 incubated inefficient lipid lipids nefa neutral oleate palmitate ppargamma protects storage stored upregulation
Tagcloud (Intersection) ?