ACSL1

Description		acyl-CoA synthetase long chain family member 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisome Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Nucleotide Binding Long-chain Fatty Acid-CoA Ligase Activity ATP Binding Ligase Activity Protein Serine/threonine Kinase Activator Activity Arachidonate-CoA Ligase Activity Phytanate-CoA Ligase Activity Pristanate-CoA Ligase Activity Palmitoyl-CoA Ligase Activity Oleoyl-CoA Ligase Activity
	Biological Process	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Response To Nutrient Lipid Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Fatty Acid Transport Triglyceride Biosynthetic Process Adiponectin-activated Signaling Pathway Response To Oleic Acid Long-chain Fatty-acyl-CoA Biosynthetic Process Xenobiotic Catabolic Process Linoleic Acid Metabolic Process Long-chain Fatty Acid Import Into Cell Positive Regulation Of Cold-induced Thermogenesis
Pathways		PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism Synthesis of very long-chain fatty acyl-CoAs MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis
Drugs		Adenosine phosphate ATP
Diseases
GWAS		Fasting glucose ( 34059833) Fulminant type 1 diabetes ( 30552108) Mean platelet volume ( 32888494) Neuroblastoma or malignant cutaneous melanoma ( 31605138) Night sleep phenotypes ( 27126917) Type 2 diabetes ( 28566273 30054458 30297969)
Interacting Genes		2 interacting genes: CEBPA NR3C2
Entrez ID		2180
HPRD ID		01068
Ensembl ID		ENSG00000151726
Uniprot IDs		A8K9T3 B4E0R0 E7EPM6 P33121
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Response To Vitamin B2 C/EBP Complex Response To Lithium Ion Transcription By RNA Polymerase I Urea Metabolic Process Sequence-specific DNA Binding Regulation Of Hematopoietic Stem Cell Proliferation Cellular Response To Lithium Ion CHOP-C/EBP Complex HMG Box Domain Binding Response To Phenylpropanoid Nitrogen Cycle Metabolic Process White Fat Cell Differentiation Urea Cycle Interleukin-6-mediated Signaling Pathway DNA-binding Transcription Factor Activity White Fat Cell Proliferation STAT Family Protein Binding Response To Hormone Osteoblast Development Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Fat Cell Proliferation Estrogen Response Element Binding Response To Lipid Brown Fat Cell Differentiation Granulocyte Differentiation Positive Regulation Of Macrophage Activation Negative Regulation Of Stem Cell Proliferation Hematopoietic Stem Cell Proliferation Embryonic Placenta Development Epithelial Cell Maturation TBP-class Protein Binding Steroid Binding Nuclear Steroid Receptor Activity Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Integrated Stress Response Signaling Acute-phase Response Macrophage Differentiation Response To Dexamethasone Nuclear Receptor Activity Animal Organ Regeneration Regulation Of Macrophage Activation Inner Ear Development Cellular Response To Xenobiotic Stimulus Acute Inflammatory Response Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Fat Cell Differentiation
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