ARHGAP4

Gene Name		Rho GTPase activating protein 4
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Microtubule Focal Adhesion Growth Cone
	Molecular Function	SH3/SH2 Adaptor Activity Rho GTPase Activator Activity Protein Binding Rac GTPase Activator Activity Rac GTPase Binding
	Biological Process	Cytoskeleton Organization Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Positive Regulation Of Signal Transduction Negative Regulation Of Fibroblast Migration Negative Regulation Of Cell Migration Negative Regulation Of Axon Extension Positive Regulation Of Rac GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways		Rho GTPase cycle Signaling by GPCR GPCR downstream signaling Signalling by NGF Cell death signalling via NRAGE, NRIF and NADE Signaling by Rho GTPases NRAGE signals death through JNK G alpha (12/13) signalling events p75 NTR receptor-mediated signalling
Drugs
Diseases
GWAS
Protein-protein Interactions		2 interactors: MAP3K1 NRAS
Entrez ID		393
HPRD ID		02063
Ensembl ID		ENSG00000089820
Uniprot IDs		F5GZW3 P98171
PDB IDs		2EPD
Enriched GO Terms of Interacting Partners?		Activation Of MAPKK Activity Fc-epsilon Receptor Signaling Pathway MAPK Cascade Fc Receptor Signaling Pathway Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Rac Protein Signal Transduction Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Kinase Activity Positive Regulation Of Kinase Activity Positive Regulation Of Transferase Activity Cellular Response To Growth Factor Stimulus Wound Healing Response To Growth Factor Actin Cytoskeleton Organization Regulation Of MAPK Cascade Actin Filament-based Process Response To Wounding Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Phosphorylation Regulation Of Immune Response Eyelid Development In Camera-type Eye Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Negative Regulation Of Skeletal Muscle Tissue Development Cell Morphogenesis Regulation Of Protein Phosphorylation Epithelium Development Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Cytoskeleton Organization Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Regulation Of Synaptic Transmission, GABAergic Immune Response Regulation Of Immune System Process Regulation Of Rac Protein Signal Transduction Regulation Of Phosphorylation Defense Response Activation Of JUN Kinase Activity Regulation Of Phosphorus Metabolic Process Epithelial Tube Branching Involved In Lung Morphogenesis
Tagcloud ?		abcf2 adprtl1 amy2b atp6ap1 axin1 casp4 cox1 cox7b ctsl etv4 lgals3bp mgc35136 mgc5528 mt2a mt3 ngfrap1 p53scv ppia prdx2 psap scgb2a2 smoc2 sptan1 sra1 tax1bp1 tpd52l1 tra1 trf4 tuba4