DEFB103A and TMPRSS2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DEFB103A	TMPRSS2
Description		defensin beta 103A	transmembrane serine protease 2
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Lumen	Extracellular Region Nucleoplasm Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding CCR6 Chemokine Receptor Binding Chemoattractant Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity
	Biological Process	Defense Response Killing Of Cells Of Another Organism Defense Response To Bacterium Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Chemotaxis Killing By Host Of Symbiont Cells Cell Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Defense Response To Symbiont	Proteolysis Protein Autoprocessing Viral Translation Positive Regulation Of Viral Entry Into Host Cell Entry Receptor-mediated Virion Attachment To Host Cell
Pathways		Beta defensins Defensins	Attachment and Entry Attachment and Entry Induction of Cell-Cell Fusion
Drugs			Bromhexine Camostat MM3122
Diseases			Prostate cancer
GWAS			Amyotrophic lateral sclerosis (sporadic) ( 24529757) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Prostate cancer ( 25217961)
Interacting Genes		11 interacting genes: AQP6 B3GALT5 EBP ERGIC3 ODF4 SCN3B SPATA31A7 SSMEM1 TMEM14B TMEM31 TMPRSS2	60 interacting genes: ACE2 ADIPOQ ANKRD46 AQP1 BMP10 BNIP2 BNIP3 BRICD5 C1QL4 C2CD2L C3orf52 CFHR5 CLEC7A CLK1 CLN6 CMTM7 CNIH2 CNIH3 CTXN3 CXCL9 CYBC1 DEFB103A DEFB103B EDDM3B ERG28 FAM3C FAXDC2 IGFBP5 MOSPD3 NINJ2 PGAP2 PLLP PLN PLP1 PLP2 PTCH1 PTTG1IP SCD SEC22A SELENOK SFTPC SLC35A1 SMIM1 STX7 STX8 TMEM11 TMEM120B TMEM128 TMEM218 TMEM222 TMEM229B TMEM243 TMEM60 TMEM79 TMEM86A TMEM86B TNF UPK2 VAMP5 ZFPL1
Entrez ID		414325	7113
HPRD ID		19320	03637
Ensembl ID		ENSG00000176797	ENSG00000184012
Uniprot IDs		A0A894JZ42 P81534	A0A7I2V474 O15393
PDB IDs		1KJ6	7MEQ 7XYD 7Y0E 7Y0F 8HD8 8JHZ 8JI0 8S0L 8S0M 8S0N 8V04 8V1F 8VGT 8Y1D 8Y1E 8Y7X 8Y7Y 8Y87 8Y88 8Y89 8Y8A 8Y8B 8YOY 8YQQ 9IZN
Enriched GO Terms of Interacting Partners?		Membrane PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport C-8 Sterol Isomerase Activity Cholesterol-5,6-oxide Hydrolase Activity Cholestenol Delta-isomerase Activity Retrograde Transporter Complex, Golgi To ER Entry Receptor-mediated Virion Attachment To Host Cell Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity Viral Translation Transporter Complex Voltage-gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport	Membrane Endoplasmic Reticulum Membrane Protein Binding Positive Regulation Of Monocyte Chemotactic Protein-1 Production Alkenylglycerophosphocholine Hydrolase Activity Endoplasmic Reticulum Respiratory Burst After Phagocytosis Response To Bacterium Cytokine Activity Positive Regulation Of Chemokine Production CCR6 Chemokine Receptor Binding Killing By Host Of Symbiont Cells Chloride Channel Inhibitor Activity SNAP Receptor Activity Biological Process Involved In Interaction With Symbiont Identical Protein Binding Regulation Of Chemokine Production Respiratory Burst Involved In Defense Response
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