MIR9-1 and HARS2

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR9-1	HARS2
Description		microRNA 9-1	histidyl-tRNA synthetase 2, mitochondrial
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm RISC Complex Extracellular Exosome	Cytoplasm Mitochondrion Mitochondrial Matrix
	Molecular Function	Single-stranded RNA Binding MRNA 3'-UTR Binding High-density Lipoprotein Particle Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleotide Binding RNA Binding Aminoacyl-tRNA Ligase Activity Histidine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity
	Biological Process	Negative Regulation Of Cell Adhesion Negative Regulation Of Cell Population Proliferation Negative Regulation Of Gene Expression Negative Regulation Of Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Osteoblast Proliferation MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Lipid Biosynthetic Process Negative Regulation Of Cholesterol Efflux Negative Regulation Of Extracellular Matrix Assembly Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lymphangiogenesis Negative Regulation Of Myofibroblast Differentiation Negative Regulation Of Xenobiotic Detoxification By Transmembrane Export Across The Plasma Membrane	Translation TRNA Aminoacylation For Protein Translation Histidyl-tRNA Aminoacylation Mitochondrial Translation
Pathways			Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Schizophrenia ( 29483656) Serum immune biomarker levels ( 32066700)
Interacting Genes		84 interacting genes: ADARB1 APOBEC3B C1QBP CELF1 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FAM98B FUS GRSF1 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT16L1 PDCD11 PLOD1 PRMT1 PTBP1 PUF60 QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYMPK SYNCRIP TAF15 TENT2 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3 ZC3H11A ZFR ZNF346 ZNF385A	22 interacting genes: AGTRAP BST2 MIR106B MIR128-2 MIR141 MIR145 MIR16-2 MIR17 MIR18B MIR199A1 MIR19B1 MIR19B2 MIR29A MIR29B1 MIR34A MIR34B MIR9-1 MIR92A2 MIR93 MIRLET7F1 MIRLET7I OGT
Entrez ID		407046	23438
HPRD ID			02871
Ensembl ID		ENSG00000207933	ENSG00000112855
Uniprot IDs			A0A2R8Y5P7 A0A2R8Y6I1 B4DDN8 P49590
PDB IDs
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process RNA Splicing Nucleic Acid Metabolic Process MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of RNA Splicing Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Ribonucleoprotein Complex Nucleus Nucleoplasm MRNA Splicing, Via Spliceosome Post-transcriptional Regulation Of Gene Expression RNA Splicing, Via Transesterification Reactions Aminoacyl-tRNA Synthetase Multienzyme Complex Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Spliceosomal Complex MRNA 3'-UTR Binding Negative Regulation Of MRNA Metabolic Process Regulation Of Translation Catalytic Step 2 Spliceosome Negative Regulation Of RNA Catabolic Process MiRNA Binding TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity Regulation Of Gene Expression TRNA Aminoacylation TRNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cytoplasmic Stress Granule Positive Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Negative Regulation Of MRNA Catabolic Process Negative Regulation Of Translation RNA Stabilization Regulation Of Primary Metabolic Process Ligase Activity Regulation Of RNA Stability MRNA Stabilization Regulation Of Alternative MRNA Splicing, Via Spliceosome Nucleolus Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing RISC Complex Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Translation Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Extracellular Vesicle Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cholesterol Efflux Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Negative Regulation Of Developmental Process MRNA Destabilization Regulation Of Translation RNA Destabilization Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Protein Metabolic Process Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cholesterol Transport Positive Regulation Of MRNA Catabolic Process Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Extracellular Matrix Assembly Regulation Of Gene Expression Positive Regulation Of Connective Tissue Replacement Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Lipid Transport Negative Regulation Of Transport Negative Regulation Of Signal Transduction Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Connective Tissue Replacement Regulation Of Cholesterol Efflux Regulation Of MRNA Stability Negative Regulation Of Cell Communication
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