LIN28B and OTUD6B

Number of citations: 50 (PubMedID 36059274)
Data Source: BioGRID (affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology)

		LIN28B	OTUD6B
Name		lin-28 RNA binding posttranscriptional regulator B	OTU deubiquitinase 6B
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Eukaryotic Translation Initiation Factor 4F Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity
	Biological Process	MiRNA Catabolic Process Post-transcriptional Regulation Of Gene Expression Regulatory NcRNA-mediated Gene Silencing Pre-miRNA Processing RNA 3'-end Processing RNA Destabilization Positive Regulation Of MiRNA Catabolic Process Negative Regulation Of Pre-miRNA Processing Negative Regulation Of Primary MiRNA Processing	Proteolysis Cell Population Proliferation Protein Deubiquitination Negative Regulation Of Translation Proteasome Assembly Positive Regulation Of Translation
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309 ) Age at menarche ( 30044860 ) Age at voice drop ( 27182965 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Body size at age 10 ( 32376654 ) Digit length ratio ( 20303062 29659830 ) Digit length ratio (left hand) ( 29659830 ) Digit length ratio (right hand) ( 29659830 ) Height ( 18391951 28552196 18391950 25429064 25282103 20881960 23563607 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) Insomnia ( 32332799 ) Intraocular pressure ( 29617998 30054594 ) Major depressive disorder ( 27479909 ) Menarche (age at onset) ( 21102462 19448623 29773799 19448622 23667675 19448620 27182965 25231870 ) Menarche and menopause (age at onset) ( 19448621 ) Metabolite levels ( 23823483 ) Neuroblastoma ( 22941191 ) Pubertal anthropometrics ( 23449627 ) Puberty onset ( 24770850 ) Puberty onset (breast development) ( 24770850 ) Schizophrenia ( 28991256 30285260 ) Sporadic neuroblastoma ( 28545128 ) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625 ) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500 ) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625 ) Waist circumference adjusted for BMI in active individuals ( 28448500 ) Waist circumference adjusted for BMI in inactive individuals ( 28448500 ) Waist circumference adjusted for BMI in non-smokers ( 28443625 ) Waist circumference adjusted for BMI in smokers ( 28443625 ) Waist circumference adjusted for body mass index ( 28448500 25673412 34021172 ) White blood cell count ( 32888494 )	No GWAS studies recorded
Interacting Genes		46 interacting genes: AURKB KAT2B MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR143 MIR145 MIR15A MIR19B1 MIR200A MIR205 MIR206 MIR221 MIR25 MIR29A MIR29B1 MIR29B2 MIR31 MIR34A MIR34B MIR429 MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I OTUD6B	6 interacting genes: LIN28B NEDD8 OTUB1 SMURF1 UBC VHL
Entrez ID		389421	51633
HPRD ID		13366	13041
Ensembl ID		ENSG00000187772	ENSG00000155100
Uniprot IDs		A0A1B0GVD3 Q6ZN17	A0A087X0W9 Q8N6M0
PDB IDs		4A4I	Not available
GO Terms Enriched among Interactors		MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization MRNA 3'-UTR Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of MRNA Metabolic Process Regulation Of Metabolic Process Regulation Of MRNA Stability Regulation Of RNA Stability Regulation Of Translation Negative Regulation Of Cell Migration Negative Regulation Of Cytokine Production Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Regulation Of MRNA Metabolic Process Extracellular Space Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Migration Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Cell Motility Positive Regulation Of Catabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Locomotion Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Communication Negative Regulation Of Signaling	Macromolecule Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process Post-translational Protein Modification Catabolic Process Proteolysis Protein Tag Activity Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Modification By Small Protein Conjugation Protein Modification Process Ubiquitin Protein Ligase Binding Nucleoplasm Negative Regulation Of TORC1 Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Engulfment Of Target By Autophagosome Negative Regulation Of TOR Signaling Proteasomal Protein Catabolic Process Macromolecule Metabolic Process Regulation Of TORC1 Signaling Protein Metabolic Process Protein Catabolic Process Cytosol Negative Regulation Of Primary MiRNA Processing Negative Regulation Of Pre-miRNA Processing Regulation Of TOR Signaling Cellular Response To Camptothecin Ubiquitin-protein Transferase Inhibitor Activity DeNEDDylase Activity Activin Receptor Binding Positive Regulation Of MiRNA Catabolic Process Extracellular Exosome Transcription Elongation Factor Activity Substrate Localization To Autophagosome Negative Regulation Of MiRNA Processing Ubiquitin-protein Transferase Activity MiRNA Catabolic Process Cytoplasm I-SMAD Binding Protein Targeting To Vacuole Involved In Autophagy Ectoderm Development Negative Regulation Of Activin Receptor Signaling Pathway Transforming Growth Factor Beta Receptor Binding Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Negative Regulation Of MiRNA-mediated Gene Silencing Regulation Of MiRNA Processing Pre-miRNA Processing Regulation Of Regulatory NcRNA Processing Receptor Catabolic Process Regulation Of Proteolysis