MIR17 and LARP7

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		MIR17	LARP7
Description		microRNA 17	La ribonucleoprotein 7, transcriptional regulator
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrion RISC Complex Extracellular Exosome Extracellular Vesicle	Nucleus Nucleoplasm Cytosol 7SK SnRNP Ribonucleoprotein Complex
	Molecular Function	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity	Nucleic Acid Binding RNA Binding Protein Binding U6 SnRNA Binding 7SK SnRNA Binding
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Chemokine Production Negative Regulation Of Toll-like Receptor Signaling Pathway MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Phagocytosis Cellular Response To Lipopolysaccharide Cellular Response To Hypoxia Cellular Response To Norepinephrine Stimulus Negative Regulation Of Cholesterol Efflux Positive Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Negative Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Sprouting Angiogenesis Negative Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Apoptosome Assembly Positive Regulation Of Pulmonary Blood Vessel Remodeling Positive Regulation Of Smooth Muscle Hypertrophy Negative Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Negative Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Negative Regulation Of Cellular Senescence Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Box C/D Sno(s)RNA 3'-end Processing RNA Processing MRNA Processing Spermatogenesis RNA Splicing Cell Differentiation Negative Regulation Of Viral Transcription Negative Regulation Of Transcription Elongation By RNA Polymerase II Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of SnRNA Transcription By RNA Polymerase II U6 2'-O-snRNA Methylation
Pathways
Drugs
Diseases
GWAS			Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Dental caries (decayed and filled deciduous teeth) ( 31533690) Meat-related diet ( 32066663) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		84 interacting genes: AIMP1 APOBEC3B ATXN2L C1QBP CELF1 CPSF6 CPSF7 CRTAP DARS1 DDX1 DDX21 DDX3X DHX36 DHX37 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KNOP1 LARP7 LARS1 LIN28A LRPPRC MARS1 MATR3 MSI2 MYEF2 NOL6 NONO NUDT21 NUFIP2 PDCD11 PLOD1 PRMT1 PTBP1 PTBP3 PUM1 PUM2 PURA QARS1 RARS1 RBFOX2 RBM14 RBM4 RTCA RTCB SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SUGP2 SYMPK SYNCRIP TAF15 TRA2A TRA2B TRMT1L UPF1 USP36 UTP20 YBX1 YBX2 YBX3 ZNF346	79 interacting genes: APP BARD1 BRCA1 JMJD6 LRRK2 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I PRPF40A RN7SK WEE2-AS1
Entrez ID		406952	51574
HPRD ID			17095
Ensembl ID		ENSG00000284536	ENSG00000174720
Uniprot IDs			A0A8I5KUI4 A0A8Q3SHH4 A0A8Q3SHN7 H0YA82 Q4G0J3
PDB IDs			4WKR 5KNW 6D12 7SLP 7SLQ
Enriched GO Terms of Interacting Partners?		RNA Binding Nucleic Acid Binding RNA Processing RNA Metabolic Process Nucleic Acid Metabolic Process RNA Splicing MRNA Processing MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process MRNA Binding Regulation Of MRNA Metabolic Process Macromolecule Metabolic Process Regulation Of RNA Splicing Cytoplasmic Stress Granule Post-transcriptional Regulation Of Gene Expression Nucleus Regulation Of Translation MRNA Splicing, Via Spliceosome Ribonucleoprotein Complex RNA Splicing, Via Transesterification Reactions Nucleoplasm Aminoacyl-tRNA Synthetase Multienzyme Complex MRNA 3'-UTR Binding Spliceosomal Complex MiRNA Binding Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Catalytic Step 2 Spliceosome Negative Regulation Of Translation Regulation Of MRNA Stability Negative Regulation Of RNA Catabolic Process Regulation Of RNA Stability Negative Regulation Of MRNA Catabolic Process RNA Stabilization TRNA Aminoacylation For Protein Translation Aminoacyl-tRNA Ligase Activity TRNA Aminoacylation MRNA Stabilization Regulation Of Gene Expression Nucleolus Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process TRNA Metabolic Process Positive Regulation Of Cytoplasmic Translation Negative Regulation Of Metabolic Process Positive Regulation Of Gene Expression Ligase Activity Paraspeckles Regulation Of Primary Metabolic Process	MiRNA-mediated Post-transcriptional Gene Silencing RISC Complex Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Metabolic Process Extracellular Vesicle Negative Regulation Of Translation MRNA Destabilization RNA Destabilization Positive Regulation Of MRNA Catabolic Process Regulation Of Angiogenesis Negative Regulation Of Cell Migration Regulation Of Gene Expression Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Negative Regulation Of Cytokine Production Negative Regulation Of Vasculature Development Negative Regulation Of Cell Motility Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of MRNA Metabolic Process Negative Regulation Of Locomotion Negative Regulation Of Vascular Endothelial Growth Factor Production Regulation Of Translation Regulation Of MRNA Stability Regulation Of Macromolecule Metabolic Process Regulation Of RNA Stability Negative Regulation Of Multicellular Organismal Process Regulation Of MRNA Metabolic Process Regulation Of Blood Vessel Endothelial Cell Migration Extracellular Space Negative Regulation Of Protein Metabolic Process Regulation Of Endothelial Cell Migration Negative Regulation Of Developmental Process Negative Regulation Of Signal Transduction Regulation Of Metabolic Process Regulation Of Cytokine Production Regulation Of Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Locomotion
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