TRIM71 and MIR100

Number of citations of the paper that reports this interaction (PubMedID 28431233)
0

Data Source:
BioGRID (unspecified method)

		TRIM71	MIR100
Description		tripartite motif containing 71	microRNA 100
Image			No pdb structure
GO Annotations	Cellular Component	P-body Cytoplasm	Extracellular Space RISC Complex Extracellular Vesicle
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Translation Repressor Activity MiRNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	MRNA 3'-UTR Binding MRNA Base-pairing Post-transcriptional Repressor Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination Neural Tube Closure Fibroblast Growth Factor Receptor Signaling Pathway Post-transcriptional Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Neural Tube Development Regulatory NcRNA-mediated Gene Silencing MiRNA Processing MiRNA-mediated Gene Silencing By Inhibition Of Translation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Metabolic Process Protein Autoubiquitination Regulation Of MiRNA-mediated Gene Silencing 3'-UTR-mediated MRNA Destabilization Stem Cell Proliferation Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of MiRNA-mediated Gene Silencing	Negative Regulation Of Gene Expression Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Interleukin-8 Production MiRNA-mediated Post-transcriptional Gene Silencing MiRNA-mediated Gene Silencing By Inhibition Of Translation MiRNA-mediated Gene Silencing By MRNA Destabilization Negative Regulation Of Osteoblast Differentiation Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Asthma ( 31959851) Asthma (childhood onset) ( 31036433) Heel bone mineral density ( 30598549) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Pulmonary function ( 21946350) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		11 interacting genes: CDKN1A MIR1-1 MIR1-2 MIR100 MIR155 MIR15A MIR18B MIR25 MIR29A MIR29B1 MIRLET7F2	1 interacting genes: TRIM71
Entrez ID		131405	406892
HPRD ID		19029
Ensembl ID		ENSG00000206557	ENSG00000207994
Uniprot IDs		Q2Q1W2
PDB IDs		7QRX
Enriched GO Terms of Interacting Partners?		RISC Complex MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing MRNA Base-pairing Post-transcriptional Repressor Activity Post-transcriptional Regulation Of Gene Expression Negative Regulation Of Gene Expression MRNA 3'-UTR Binding MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Negative Regulation Of Developmental Process Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Translation Negative Regulation Of Cell Cycle G1/S Phase Transition Extracellular Vesicle Negative Regulation Of Amyloid-beta Formation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Negative Regulation Of Circulating Fibrinogen Levels Regulation Of Mitotic Cell Cycle Phase Transition MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Amyloid-beta Formation Negative Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Epithelial Cell Differentiation Regulation Of Gene Expression Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Translation Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Cycle Phase Transition Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Regulation Of Multicellular Organismal Process Regulation Of Amide Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle Process Negative Regulation Of Developmental Growth MRNA Destabilization	3'-UTR-mediated MRNA Destabilization Positive Regulation Of MiRNA-mediated Gene Silencing Translation Repressor Activity Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing MiRNA Binding MiRNA Processing Neural Tube Development MiRNA-mediated Gene Silencing By Inhibition Of Translation Regulation Of Neural Precursor Cell Proliferation MRNA Destabilization RNA Destabilization Tube Closure Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle P-body Stem Cell Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Protein Autoubiquitination Neural Tube Closure Positive Regulation Of MRNA Catabolic Process MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Tube Formation Post-transcriptional Gene Silencing Positive Regulation Of MRNA Metabolic Process Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulatory NcRNA-mediated Gene Silencing Negative Regulation Of Translation Regulation Of MRNA Stability Tube Development Regulation Of RNA Stability Epithelium Development Ubiquitin-protein Transferase Activity Protein Polyubiquitination
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