LOXL1 and MFGE8

		LOXL1	MFGE8
Description		lysyl oxidase like 1	milk fat globule EGF and factor V/VIII domain containing
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Basement Membrane Extracellular Space Extracellular Matrix	Acrosomal Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen External Side Of Plasma Membrane Membrane Extracellular Matrix Cytoplasmic Vesicle Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein-lysine 6-oxidase Activity Copper Ion Binding Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, Oxygen As Acceptor Metal Ion Binding	Phosphatidylserine Binding Integrin Binding Extracellular Matrix Structural Constituent
	Biological Process	Protein Deamination Collagen Fibril Organization Response To Lipopolysaccharide Aorta Development	Angiogenesis Cell Adhesion Single Fertilization Apoptotic Cell Clearance
Pathways		Elastic fibre formation Crosslinking of collagen fibrils	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation Amyloid fiber formation Developmental Lineage of Mammary Gland Alveolar Cells
Drugs
Diseases
GWAS		A body shape index ( 34021172) Adult body size ( 32376654) Aortic root size ( 19584346) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Coronary artery disease ( 33020668 29212778) Diverticular disease ( 30177863) Exfoliation glaucoma or exfoliation syndrome ( 24938310) Exfoliation syndrome ( 25706626) Glaucoma (exfoliation) ( 17690259) Glaucoma (primary open-angle) ( 33627673) Hand grip strength ( 29691431) Height ( 28552196 23563607 31562340) Hip circumference adjusted for BMI ( 34021172) Joint mobility (Beighton score) ( 27182965) Pelvic organ prolapse ( 32184442) Pseudoexfoliation syndrome ( 29278698) Refractive error ( 32231278) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 28448500 25673412) Waist-hip index ( 34021172) Youthful appearance (self-reported) ( 32339537)	Blood protein levels ( 30072576) Coronary artery disease ( 26343387 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Liver enzyme levels (alkaline phosphatase) ( 33972514) Major depressive disorder x sex interaction ( 34099189) Pulse pressure ( 27841878) Serum alkaline phosphatase levels ( 33547301) Squamous cell lung carcinoma ( 28604730)
Interacting Genes		3 interacting genes: ATXN1 ELN FBLN5	1 interacting genes: RSPH1
Entrez ID		4016	4240
HPRD ID		08861	03789
Ensembl ID		ENSG00000129038	ENSG00000140545
Uniprot IDs		H3BUV8 Q08397	A0A8Q3SIZ9 B3KTQ2 B4E396 H0YKB5 Q08431
PDB IDs
Enriched GO Terms of Interacting Partners?		Elastic Fiber Extracellular Matrix Constituent Conferring Elasticity Extracellular Matrix Assembly Extracellular Matrix Extracellular Matrix Structural Constituent Intramembranous Bone Growth Integrin Binding Extracellular Structure Organization Extracellular Matrix Organization POZ Domain Binding Regulation Of Removal Of Superoxide Radicals Poly(G) Binding Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Response To Reactive Oxygen Species Elastic Fiber Assembly Nuclear Inclusion Body Positive Regulation Of Osteoblast Proliferation Regulation Of Cell Population Proliferation Respiratory Gaseous Exchange By Respiratory System Extracellular Region Extracellular Matrix Binding Stress Fiber Assembly Supramolecular Fiber Organization Contractile Actin Filament Bundle Assembly Acrosomal Membrane Apoptotic Cell Clearance Poly(U) RNA Binding Positive Regulation Of Glial Cell Proliferation Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Response To Oxidative Stress Regulation Of Osteoblast Proliferation Regulation Of Cellular Response To Oxidative Stress Protein Localization To Cell Surface Regulation Of Superoxide Metabolic Process Bone Growth
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