VMAC and NGLY1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		VMAC	NGLY1
Description		vimentin type intermediate filament associated coiled-coil protein	N-glycanase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Type III Intermediate Filament	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine Amidase Activity Protein Binding Hydrolase Activity Metal Ion Binding
	Biological Process		Protein Folding Glycoprotein Catabolic Process Positive Regulation Of BMP Signaling Pathway
Pathways			N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Drugs
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		16 interacting genes: DLG4 KANK2 LMO2 LMO3 LMO4 LNX1 NGLY1 PSMA1 SAXO4 SCNM1 SDK2 SPG21 TFAP4 ZBTB25 ZNF326 ZNF80	19 interacting genes: APP BICRAL FAF1 GUCD1 NPAS2 NSFL1C PAX5 PAX6 RAD23A RAD23B SRPK2 TCF12 TRAFD1 TRIM54 UBC UBQLN1 UBXN2B VCP VMAC
Entrez ID		400673	55768
HPRD ID		18623	10118
Ensembl ID		ENSG00000187650	ENSG00000151092
Uniprot IDs		Q2NL98	Q96IV0
PDB IDs			2CCQ 2CM0
Enriched GO Terms of Interacting Partners?			Polyubiquitin Modification-dependent Protein Binding Ubiquitin Binding Modification-dependent Protein Catabolic Process Proteasome Complex VCP-NSFL1C Complex Negative Regulation Of Protein Localization To Centrosome Proteolysis Involved In Protein Catabolic Process Proteasomal Protein Catabolic Process Positive Regulation Of Mitotic Centrosome Separation Positive Regulation Of Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Catabolic Process Establishment Of Mitotic Spindle Orientation Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Catabolic Process Establishment Of Mitotic Spindle Localization Establishment Of Spindle Orientation Microtubule Cytoskeleton Organization Involved In Mitosis Proteolysis Regulation Of Mitotic Centrosome Separation VCP-NPL4-UFD1 AAA ATPase Complex Establishment Of Spindle Localization Spindle Localization Macromolecule Catabolic Process Positive Regulation Of Cell Cycle HMG Box Domain Binding Regulation Of Protein Localization To Centrosome Positive Regulation Of Proteolysis Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Localization Proteasome Binding Ubiquitin-specific Protease Binding ERAD Pathway Autophagosome Assembly Autophagosome Organization Negative Regulation Of Hippo Signaling Nuclear Membrane Reassembly Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Viral Genome Replication Response To Stress Microtubule-based Process Ubiquitin Protein Ligase Binding Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of Catabolic Process Central Nervous System Development Regulation Of Response To Calcium Ion
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