LMAN1 and BCAP31

Number of citations of the paper that reports this interaction (PMID 19342655)
4

Data Source:
BioGRID (fluorescent resonance energy transfer, imaging technique)

		LMAN1	BCAP31
Gene Name		lectin, mannose-binding, 1	B-cell receptor-associated protein 31
Image
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Sarcomere Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Host Cell Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Particle Cytosol Integral Component Of Plasma Membrane Membrane Clathrin-coated Vesicle Golgi Cisterna Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding Mannose Binding Metal Ion Binding Unfolded Protein Binding	Protein Binding Protein Complex Binding MHC Class I Protein Binding
	Biological Process	Protein Folding ER To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Golgi Organization Blood Coagulation Positive Regulation Of Organelle Organization Protein N-linked Glycosylation Via Asparagine Protein Exit From Endoplasmic Reticulum Early Endosome To Golgi Transport Post-translational Protein Modification Cellular Protein Metabolic Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Positive Regulation Of Cytosolic Calcium Ion Concentration Spermatogenesis Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Calcium-mediated Signaling Using Intracellular Calcium Source Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Mitochondrial Calcium Ion Concentration Protein Localization To Endoplasmic Reticulum Exit Site Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Defective ALG2 causes ALG2-CDG (CDG-1i) Diseases of glycosylation Defective ALG3 causes ALG3-CDG (CDG-1d) Post-translational protein modification Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) Transport to the Golgi and subsequent modification Defective MGAT2 causes MGAT2-CDG (CDG-2a) Defective ALG1 causes ALG1-CDG (CDG-1k) Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective ALG6 causes ALG6-CDG (CDG-1c) Defective RFT1 causes RFT1-CDG (CDG-1n) Defective MOGS causes MOGS-CDG (CDG-2b) Asparagine N-linked glycosylation Defective ALG8 causes ALG8-CDG (CDG-1h) Defective ALG9 causes ALG9-CDG (CDG-1l) Defective MPDU1 causes MPDU1-CDG (CDG-1f) Defective MAN1B1 causes MRT15 Defective ALG12 causes ALG12-CDG (CDG-1g) Diseases associated with N-glycosylation of proteins Defective ALG11 causes ALG11-CDG (CDG-1p)	Apoptotic cleavage of cellular proteins Programmed Cell Death Apoptotic execution phase Class I MHC mediated antigen processing & presentation Antigen Presentation: Folding, assembly and peptide loading of class I MHC Adaptive Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP BCAP31 F8 MCFD2	25 interactors: ACTG1 APP BCAP29 BCL2 BCL2L1 CANX CASP1 CASP3 CASP8 FIS1 GPRIN2 HACD2 HLA-A IGHD KLK10 LMAN1 MSN MYH10 PLP2 SERPINF2 VAMP1 VAMP2 VAMP3 VKORC1 YWHAQ
Entrez ID		3998	10134
HPRD ID		03338	02319
Ensembl ID		ENSG00000074695	ENSG00000185825
Uniprot IDs		P49257	P51572
PDB IDs		3A4U 3LCP 4GKX 4GKY	4JZL 4JZP
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Calcium Ion Homeostasis Vesicle-mediated Transport Platelet Degranulation Positive Regulation Of Peptidase Activity Synaptic Growth At Neuromuscular Junction Platelet Activation Collateral Sprouting In Absence Of Injury Collateral Sprouting Axon Midline Choice Point Recognition Cellular Calcium Ion Homeostasis Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization To Endoplasmic Reticulum Exit Site Calcium Ion Homeostasis Axon Choice Point Recognition Exocytosis Neuron Remodeling Regulation Of Endopeptidase Activity Positive Regulation Of Mitochondrial Calcium Ion Concentration Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Cellular Metal Ion Homeostasis Regulation Of Peptidase Activity Blood Coagulation Hemostasis Transport Cellular Cation Homeostasis Calcium-mediated Signaling Using Intracellular Calcium Source Cellular Ion Homeostasis Establishment Of Localization In Cell Metal Ion Homeostasis Blood Coagulation, Intrinsic Pathway Secretion By Cell Mitochondrial Calcium Ion Homeostasis Cellular Chemical Homeostasis Cellular Copper Ion Homeostasis Ion Homeostasis Regulation Of Body Fluid Levels Wound Healing Copper Ion Homeostasis Suckling Behavior Cellular Localization Secretion Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Proteolysis Cell Activation Cellular Homeostasis Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Response To Wounding	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Establishment Of Localization In Cell Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrion Organization Vesicle-mediated Transport Membrane Organization Cellular Localization Apoptotic Process Response To Wounding Neuron Apoptotic Process Immune System Process Programmed Cell Death Positive Regulation Of Peptidase Activity Positive Regulation Of Mitochondrion Organization Cell Death Death Neuron Death Secretion By Cell Apoptotic Mitochondrial Changes Exocytosis Apoptotic Signaling Pathway Organelle Fusion Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Transport Positive Regulation Of Cell Death Regulation Of Endopeptidase Activity Secretion Immune Response Positive Regulation Of Organelle Organization Regulation Of Peptidase Activity Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Establishment Of Protein Localization Positive Regulation Of Intracellular Transport Regulation Of Cellular Localization Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Cysteine-type Endopeptidase Activity Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Membrane Fusion Intracellular Transport Regulation Of Protein Localization Positive Regulation Of Endopeptidase Activity
Tagcloud ?		abnormal abnormality cargo cis compartment direct electroretinogram er ergic eyes gm130 golgi grasp65 histology homeostasis intermediate location markers months mouse nrl photoreceptor retina rhodopsin selectively taken transmembrane transport transports	24h 48h anova aureus caprine cd2bp2 challenged chemotactic cxcl6 dairy fosl2 goats granulocyte halves ilt5 infused intramammary intricacy junb lymphotoxin mapk13 mastitis mhcii microarrays mscs pbs udder udders veterinary
Tagcloud (Difference) ?		abnormal abnormality cargo cis compartment direct electroretinogram er ergic eyes gm130 golgi grasp65 histology homeostasis intermediate location markers months mouse nrl photoreceptor retina rhodopsin selectively taken transmembrane transport transports	24h 48h anova aureus caprine cd2bp2 challenged chemotactic cxcl6 dairy fosl2 goats granulocyte halves ilt5 infused intramammary intricacy junb lymphotoxin mapk13 mastitis mhcii microarrays mscs pbs udder udders veterinary
Tagcloud (Intersection) ?