CENPW and CENPB

Number of citations of the paper that reports this interaction (PubMedID 25775162)
125

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CENPW	CENPB
Description		centromere protein W	centromere protein B
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Inner Kinetochore Nucleus Nucleoplasm Chromosome Nucleolus Nuclear Matrix	Chromosome, Centromeric Region Condensed Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Pericentric Heterochromatin Nuclear Body
	Molecular Function	DNA Binding Protein Binding Protein Heterodimerization Activity	Nucleic Acid Binding DNA Binding Chromatin Binding Satellite DNA Binding Protein Binding Centromeric DNA Binding Sequence-specific DNA Binding
	Biological Process	Mitotic Cell Cycle Chromosome Segregation CENP-A Containing Chromatin Assembly Chromosome Organization Cell Division Kinetochore Assembly
Pathways		Deposition of new CENPA-containing nucleosomes at the centromere
Drugs
Diseases
GWAS		A body shape index ( 34021172) Aspartate aminotransferase levels ( 33547301) Birth weight ( 31043758) Body fat percentage and type 2 diabetes (pairwise) ( 33619380) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels ( 30388399) Caffeine consumption from coffee or tea ( 33287642) Coronary artery disease ( 29212778) Cortical surface area (global PC1) ( 32198502) Cortical surface area (visual PC2) ( 32198502) Diastolic blood pressure ( 27841878) Feeling nervous ( 29500382) Food addiction ( 27106561) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412 34021172) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Intracranial volume ( 22504418) Intraocular pressure ( 29617998) Kidney volume ( 34128465) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965 29146897 28196072) Menarche (age at onset) ( 25231870 27182965) Monobrow ( 27182965) Myocardial infarction ( 33532862) Neurociticism ( 29500382) Neuroticism ( 29255261) Occipital lobe volume ( 31396565) Optic disc size ( 31809533) Pulse pressure ( 27841878) QT interval ( 29213071) Subcortical brain region volumes ( 25607358) Subcortical volume (MOSTest) ( 32665545) Systolic blood pressure ( 27841878) Type 1 diabetes ( 30659077 30572963) Type 2 diabetes ( 32499647 28869590 30297969) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: BTRC CENPB CUL1 H3C1 NPM1	20 interacting genes: ADRB2 ANXA7 APP CDKN1A CENPW FBXO25 GADD45A GFI1B GSK3B HAND2 NR3C1 PARP1 PARP2 PIN1 RPS6KA6 SH2D3A SMN1 TAC1 TADA3 TK1
Entrez ID		387103	1059
HPRD ID		16660	00314
Ensembl ID		ENSG00000203760	ENSG00000125817
Uniprot IDs		A0A0A0MRK5 Q5EE01	P07199
PDB IDs		7QOO 7R5S 7XHN 7XHO 7YWX	1BW6 1HLV 1UFI 6KDR
Enriched GO Terms of Interacting Partners?		Lysosome Organization Negative Regulation Of TORC1 Signaling SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process TORC1 Signaling SCF Ubiquitin Ligase Complex Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Negative Regulation Of Autophagy Autophagosome Organization Autophagosome Assembly Regulation Of TORC1 Signaling Negative Regulation Of TOR Signaling Protein K48-linked Ubiquitination TOR Signaling Nucleosome Assembly Regulation Of Endoribonuclease Activity Nucleosome Organization Protein Phosphorylated Amino Acid Binding Nucleoplasm Organelle Assembly Regulation Of TOR Signaling Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Vacuole Organization Positive Regulation Of Autophagy Satellite DNA Binding Protein-DNA Complex Assembly Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Regulation Of Ribonuclease Activity Positive Regulation Of Centrosome Duplication Centromeric DNA Binding Positive Regulation Of Protein Localization To Nucleolus Ribosomal Large Subunit Export From Nucleus Cellular Component Assembly Organelle Organization Regulation Of Endodeoxyribonuclease Activity Ribosomal Small Subunit Export From Nucleus Granular Component Cellular Response To Nutrient Levels Ubiquitin Ligase Complex Scaffold Activity Protein Polyubiquitination Tat Protein Binding Regulation Of Protein Localization To Nucleolus Ribosomal Subunit Export From Nucleus Negative Regulation Of Centrosome Duplication Regulation Of Canonical NF-kappaB Signal Transduction Ubiquitin Ligase Activator Activity Ribosomal Large Subunit Binding Regulation Of Protein Stability Spindle Pole Centrosome Cullin-RING Ubiquitin Ligase Complex	Cellular Response To Amyloid-beta Response To Amyloid-beta NAD+-protein-serine ADP-ribosyltransferase Activity Neuronal Dense Core Vesicle DNA ADP-ribosylation NAD DNA ADP-ribosyltransferase Activity Nucleus Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Response To Nerve Growth Factor Stimulus Response To Nerve Growth Factor Chromatin Organization Regulation Of Developmental Process Positive Regulation Of Programmed Cell Death Regulation Of System Process Regulation Of Protein Localization To Nucleus Regulation Of Multicellular Organismal Process Regulation Of Developmental Growth Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Protein Auto-ADP-ribosylation Negative Regulation Of Macromolecule Metabolic Process Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Neuron Apoptotic Process Antifungal Humoral Response Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Developmental Process Regulation Of Cardiac Muscle Hypertrophy NAD+-protein-glutamate ADP-ribosyltransferase Activity Regulation Of MAPK Cascade Negative Regulation Of Macromolecule Biosynthetic Process NAD+-protein-aspartate ADP-ribosyltransferase Activity Negative Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Intracellular Signal Transduction Regulation Of Membrane Potential Response To Yeast Positive Regulation Of CAMP/PKA Signal Transduction Regulation Of Cell Cycle Regulation Of Muscle System Process Protein Poly-ADP-ribosylation Regulation Of Neuron Apoptotic Process Regulation Of Transcription By RNA Polymerase II Response To Lipid NAD+-protein Mono-ADP-ribosyltransferase Activity Regulation Of Mitotic Cell Cycle Negative Regulation Of Systemic Arterial Blood Pressure
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