KRT6A and KRT7

Number of citations of the paper that reports this interaction (PubMedID 35575683)
0

Data Source:
BioGRID (cross-linking study)

		KRT6A	KRT7
Description		keratin 6A	keratin 7
Image
GO Annotations	Cellular Component	Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome	Nucleus Cytoplasm Cytosol Intermediate Filament Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis	Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Morphogenesis Of An Epithelium Positive Regulation Of Cell Population Proliferation Cell Differentiation Keratinization Killing Of Cells Of Another Organism Wound Healing Intermediate Filament Organization Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Entry Of Bacterium Into Host Cell	Keratinization Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope Developmental Lineage of Pancreatic Ductal Cells
Drugs		Zinc Zinc acetate	Primaquine Verpasep caltespen
Diseases		Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS		Cutaneous squamous cell carcinoma ( 32041948)	Blond vs. brown/black hair color ( 30531825) Diisocyanate-induced asthma ( 25918132)
Interacting Genes		37 interacting genes: BEX2 CCDC85B DSP GEM GOLGA2 HGS KDM1A KIFC3 KRT13 KRT15 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 LMNA MTUS2 NCALD NUP62 SGTA SMARCB1 TCHP TFIP11 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3	11 interacting genes: ATF7IP EGFR HMGB1 HSPA1A KDM1A KRT13 KRT17 KRT27 LAPTM5 LINC01554 UBE3A
Entrez ID		3853	3855
HPRD ID		01011	01014
Ensembl ID		ENSG00000205420	ENSG00000135480
Uniprot IDs		A0A0S2Z428 P02538	P08729
PDB IDs		5KI0	4XIF
Enriched GO Terms of Interacting Partners?		Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Epithelial Cell Differentiation Cytoskeleton Organelle Organization Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Keratinization Extracellular Exosome Cellular Developmental Process Intermediate Filament Cytoskeleton Cell Differentiation Anatomical Structure Morphogenesis Hair Follicle Morphogenesis Epidermis Development Developmental Process Scaffold Protein Binding Cytosol Hair Cycle Process Protein Binding Adherens Junction Cornified Envelope Tissue Development Epithelial Cell-cell Adhesion Peptide Cross-linking Positive Regulation Of ERAD Pathway	Structural Constituent Of Skin Epidermis Intermediate Filament Organization Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Morphogenesis Of An Epithelium Tissue Morphogenesis Regulation Of Protein Ubiquitination Positive Regulation Of Protein Metabolic Process Transcription Corepressor Activity Keratinization Hair Cycle Process Regulation Of Post-translational Protein Modification Supramolecular Fiber Organization Regulation Of Protein Metabolic Process Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Protein Ubiquitination Regulation Of Protein Modification Process Positive Regulation Of Post-translational Protein Modification Positive Regulation Of Protein Modification Process Positive Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Positive Regulation Of Biosynthetic Process Hair Follicle Morphogenesis Regulation Of Ubiquitin-dependent Protein Catabolic Process Structural Molecule Activity Regulation Of Activated T Cell Proliferation Negative Regulation Of Type II Interferon Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress Regulation Of Cell Population Proliferation Cell Differentiation Regulation Of DNA Repair Multivesicular Body, Internal Vesicle Lumen Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Response To Steroid Hormone Positive Regulation Of Myeloid Progenitor Cell Differentiation Intermediate Filament Polymerization Cytoskeleton Organization Intermediate Filament Cytoskeleton Sperm Entry Positive Regulation Of Golgi Lumen Acidification Induction Of Programmed Cell Death Negative Regulation Of Pre-B Cell Receptor Expression Positive Regulation Of Lysosomal Membrane Permeability Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction
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