KRT4 and KRT6A

		KRT4	KRT6A
Description		keratin 4	keratin 6A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Intermediate Filament Cell Surface Keratin Filament Intermediate Filament Cytoskeleton	Nucleus Cytosol Intermediate Filament Membrane Keratin Filament Extracellular Exosome
	Molecular Function	Protein Binding Structural Constituent Of Skin Epidermis	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Cytoskeleton Organization Epithelial Cell Differentiation Keratinization Intermediate Filament Organization Negative Regulation Of Epithelial Cell Proliferation	Morphogenesis Of An Epithelium Positive Regulation Of Cell Population Proliferation Cell Differentiation Keratinization Killing Of Cells Of Another Organism Wound Healing Intermediate Filament Organization Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Negative Regulation Of Entry Of Bacterium Into Host Cell
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs			Zinc Zinc acetate
Diseases		White sponge nevus	Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
GWAS			Cutaneous squamous cell carcinoma ( 32041948)
Interacting Genes		22 interacting genes: C14orf119 CCDC57 CEP57 KIFC3 KRT14 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT31 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT40 PPP1R13B TRIM54 TUBGCP4	37 interacting genes: BEX2 CCDC85B DSP GEM GOLGA2 HGS KDM1A KIFC3 KRT13 KRT15 KRT17 KRT18 KRT19 KRT25 KRT26 KRT27 KRT28 KRT31 KRT34 KRT35 KRT36 KRT38 KRT40 LMNA MTUS2 NCALD NUP62 SGTA SMARCB1 TCHP TFIP11 TRIM23 TRIM54 TSGA10 TXLNB UBQLN2 WASHC3
Entrez ID		3851	3853
HPRD ID		00478	01011
Ensembl ID		ENSG00000170477	ENSG00000205420
Uniprot IDs		P19013	A0A0S2Z428 P02538
PDB IDs			5KI0
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Keratin Filament Intermediate Filament-based Process Intermediate Filament Organization Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Morphogenesis Of An Epithelium Cytoskeleton Organization Tissue Morphogenesis Cytoskeleton Epithelial Cell Differentiation Organelle Organization Anatomical Structure Morphogenesis Extracellular Exosome Structural Constituent Of Cytoskeleton Cell Differentiation Cellular Developmental Process Cytosol Hair Cycle Developmental Process Hair Follicle Morphogenesis Epidermis Development Hair Cycle Process Cell Periphery Microtubule Nucleation Centriolar Satellite Gamma-tubulin Binding Microtubule Intermediate Filament Polymerization Sulfite Oxidase Activity Protein Binding Intermediate Filament Polymerization Or Depolymerization Negative Regulation Of Entry Of Bacterium Into Host Cell Zonula Adherens Maintenance Terminal Web Molybdenum Ion Binding Keratinization Scaffold Protein Binding Microtubule Binding Molybdopterin Cofactor Binding	Intermediate Filament Organization Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Structural Constituent Of Skin Epidermis Keratin Filament Intermediate Filament Structural Molecule Activity Supramolecular Fiber Organization Cytoskeleton Organization Epithelial Cell Differentiation Cytoskeleton Organelle Organization Tissue Morphogenesis Morphogenesis Of An Epithelium Structural Constituent Of Cytoskeleton Keratinization Extracellular Exosome Cellular Developmental Process Intermediate Filament Cytoskeleton Cell Differentiation Anatomical Structure Morphogenesis Hair Follicle Morphogenesis Epidermis Development Developmental Process Scaffold Protein Binding Cytosol Hair Cycle Process Protein Binding Adherens Junction Cornified Envelope Tissue Development Epithelial Cell-cell Adhesion Peptide Cross-linking Positive Regulation Of ERAD Pathway
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