KRT2 and KRT39

Number of citations of the paper that reports this interaction (PubMedID 36949045)
82

Data Source:
BioGRID (two hybrid)

		KRT2	KRT39
Description		keratin 2	keratin 39
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Extracellular Space Nucleus Cytoplasm Cytosol Intermediate Filament Membrane Keratin Filament Intermediate Filament Cytoskeleton Extracellular Exosome	Cytosol Cytoskeleton Intermediate Filament Keratin Filament
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Skin Epidermis	Structural Molecule Activity Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Keratinocyte Development Epidermis Development Peptide Cross-linking Keratinization Keratinocyte Activation Keratinocyte Proliferation Intermediate Filament Organization Positive Regulation Of Epidermis Development Keratinocyte Migration	Morphogenesis Of An Epithelium Epithelial Cell Differentiation Intermediate Filament Organization
Pathways		Keratinization Formation of the cornified envelope	Keratinization Formation of the cornified envelope
Drugs		Zinc Copper Anthralin Zinc acetate
Diseases		Ichthyosis bullosa of Siemens
GWAS
Interacting Genes		20 interacting genes: EVPL KRT13 KRT24 KRT25 KRT27 KRT28 KRT31 KRT32 KRT33B KRT34 KRT35 KRT36 KRT37 KRT38 KRT39 KRT40 OGT RNF26 SIRPA SMAD3	34 interacting genes: ANKS1A ARMC7 BEX2 C1orf216 CCDC196 CLCNKA FAM110A GFAP HGS IGFN1 KDM1A KLHL38 KRT1 KRT2 KRT3 KRT6B KRT74 KRT76 KRT78 KRT81 KRT83 KRT85 KRT86 LMO4 PPL PRPF18 SCNM1 SHC3 SMARCE1 TGM7 TXLNB UBASH3A VPS9D1 ZNF417
Entrez ID		3849	390792
HPRD ID		02560	13750
Ensembl ID		ENSG00000172867	ENSG00000196859
Uniprot IDs		P35908	Q6A163
PDB IDs
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Skin Epidermis Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Intermediate Filament Organization Keratin Filament Intermediate Filament Structural Molecule Activity Epithelial Cell Differentiation Morphogenesis Of An Epithelium Tissue Morphogenesis Supramolecular Fiber Organization Cytoskeleton Organization Organelle Organization Cytoskeleton Anatomical Structure Morphogenesis Cellular Developmental Process Cell Differentiation Extracellular Exosome Developmental Process Cytosol Hair Follicle Morphogenesis Epidermis Development Intermediate Filament Cytoskeleton Hair Cycle Process Hair Cycle Tissue Development Negative Regulation Of Lung Blood Pressure Nuclear Mineralocorticoid Receptor Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transforming Growth Factor Beta3 Production Regulation Of Nitric Oxide Biosynthetic Process Cellular Response To Interleukin-12 Cellular Response To Glucose Stimulus	Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Keratinization Intermediate Filament Organization Structural Constituent Of Skin Epidermis Intermediate Filament Keratin Filament Supramolecular Fiber Organization Cytoskeleton Organization Epidermis Development Organelle Organization Structural Constituent Of Cytoskeleton Cornified Envelope Tissue Development Peptide Cross-linking
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