KPNB1 and RANBP1

Number of citations of the paper that reports this interaction (PMID 8909533)
63

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, pull down)

		KPNB1	RANBP1
Gene Name		karyopherin (importin) beta 1	RAN binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Membrane Extracellular Vesicular Exosome Endoplasmic Reticulum Tubular Network	Nucleus Nuclear Envelope Cytoplasm
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Ran GTPase Binding Protein Transporter Activity Enzyme Binding Protein Domain Specific Binding Poly(A) RNA Binding	GDP-dissociation Inhibitor Activity GTPase Activator Activity Ran GTPase Binding
	Biological Process	Protein Import Into Nucleus, Translocation Apoptotic DNA Fragmentation Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Ribosomal Protein Import Into Nucleus Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Viral Process Viral Life Cycle Cytokine-mediated Signaling Pathway Small Molecule Metabolic Process Intracellular Transport Of Virus	Signal Transduction Viral Process Positive Regulation Of GTPase Activity Intracellular Transport Regulation Of Catalytic Activity
Pathways		Metabolism of lipids and lipoproteins ISG15 antiviral mechanism Nuclear import of Rev protein HIV Infection Interferon Signaling Apoptotic execution phase Host Interactions of HIV factors Cytokine Signaling in Immune system Interactions of Rev with host cellular proteins Influenza Infection Antiviral mechanism by IFN-stimulated genes Influenza Life Cycle Regulation of cholesterol biosynthesis by SREBP (SREBF) Activation of DNA fragmentation factor Transport of Ribonucleoproteins into the Host Nucleus Apoptosis induced DNA fragmentation Programmed Cell Death	HIV Life Cycle Rev-mediated nuclear export of HIV RNA HIV Infection Rev-mediated nuclear export of HIV RNA Host Interactions of HIV factors Interactions of Rev with host cellular proteins Late Phase of HIV Life Cycle
Drugs
Diseases
GWAS		Multiple sclerosis ( 22190364)
Protein-Protein Interactions		59 interactors: AMFR CD99 CHD3 CSE1L CSNK1A1 CUL4B ELAVL1 EXO1 FGFR1 H1F0 HIST1H1C IGFBP3 IGFBP5 IPO7 IPO8 KPNA1 KPNA2 KPNA3 KPNA4 KPNA6 LYST MESDC2 MSL1 NFATC1 NFYA NUP153 NUP50 NUP54 NUP62 NUP98 NUTF2 PIAS4 PLCD1 PRKD3 PTHLH PTMA PTN PTPN2 RAN RANBP1 RANBP2 RCC1 RPL5 RUNX1T1 SMAD2 SMAD3 SMN1 SMNDC1 SNUPN SOX9 SREBF2 SRY TAF3 TAF8 TERF1 TP53 TUBA1A UBR5 VIMP	8 interactors: CD93 KPNB1 MDM2 NUPR1 RAN RANGRF RCC1 XPO1
Entrez ID		3837	5902
HPRD ID		04114	03110
Ensembl ID			ENSG00000099901
Uniprot IDs		B7Z752 B7ZAV6 Q14974	B4DE76 D3DX26 P43487
PDB IDs		1F59 1IBR 1M5N 1O6O 1O6P 1QGK 1QGR 2P8Q 2Q5D 2QNA 3LWW	1K5D 1K5G
Enriched GO Terms of Interacting Partners?		Nucleocytoplasmic Transport Nuclear Transport Nuclear Import Protein Localization To Nucleus Protein Import Into Nucleus Viral Process Cytoplasmic Transport Protein Import Intracellular Transport Protein Localization Protein Transport Establishment Of Protein Localization Cellular Localization Establishment Of Localization In Cell Protein Localization To Organelle Protein Targeting Cellular Protein Localization Intracellular Protein Transport Establishment Of Protein Localization To Organelle Viral Life Cycle Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Mitotic Nuclear Envelope Disassembly Cellular Nitrogen Compound Metabolic Process Nuclear Envelope Disassembly Gene Expression Cellular Response To Cytokine Stimulus Cell Cycle NLS-bearing Protein Import Into Nucleus Cell Cycle Process Viral Transcription Regulation Of Glucose Transport RNA Metabolic Process Cellular Response To Organic Substance Mitotic Cell Cycle Process Nitrogen Compound Metabolic Process Cytokine-mediated Signaling Pathway Response To Cytokine Cellular Response To Stimulus Nuclear Envelope Organization RNA Biosynthetic Process Mitotic Cell Cycle Glucose Transport Cellular Metabolic Process Hexose Transport Signal Transduction RNA Transport RNA Localization Response To Organic Substance	Viral Process Intracellular Transport Of Virus Protein Localization To Nucleus Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Subunit Export From Nucleus Protein Localization To Organelle Viral Life Cycle Cellular Protein Localization Regulation Of Protein Export From Nucleus Establishment Of Protein Localization Cytoplasmic Transport Protein Export From Nucleus Mitotic Cell Cycle Nucleocytoplasmic Transport Nuclear Transport Mitotic Spindle Organization Intracellular Protein Transport Regulation Of Cell Cycle Protein Localization Protein Exit From Endoplasmic Reticulum Cellular Response To UV-C Cellular Response To Vitamin B1 Regulation Of Cell Cycle Process Cellular Localization Cell Cycle Signal Transduction By P53 Class Mediator Nuclear Export Protein Transport Protein Import Into Nucleus Nuclear Import Spindle Organization Intracellular Transport Regulation Of Establishment Of Protein Localization Protein Import Mitotic Cell Cycle Process Traversing Start Control Point Of Mitotic Cell Cycle Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Response To Toxic Substance Regulation Of Membrane Depolarization During Action Potential Response To Vitamin B1 Response To Ether Ribosome Biogenesis Regulation Of Protein Localization Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Metabolic Process Positive Regulation Of Protein Localization To Cell Surface Ribosomal Protein Import Into Nucleus Regulation Of Cardiac Muscle Cell Action Potential Establishment Of Localization In Cell
Tagcloud ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	antileukemic blocks chief crm1 deeper designated engrafted export groove immunodeficient kpt library mediator modeling nanomolar negligible nes occupied occupies orally penetrates potencies representative representing sine therapeutics virtual warrant
Tagcloud (Difference) ?		30d enhancer ezh2 forced homologue immunohistochemical importantly malignancies mir mpnst mpnsts negatively nerve neurofibromatosis nodes polycomb recur represents rescues sheath signalling sporadically suppresses targetable tumourigenesis tumourigenicity tumours utr zeste	antileukemic blocks chief crm1 deeper designated engrafted export groove immunodeficient kpt library mediator modeling nanomolar negligible nes occupied occupies orally penetrates potencies representative representing sine therapeutics virtual warrant
Tagcloud (Intersection) ?