KLRB1 and CLEC2D

Number of citations of the paper that reports this interaction (PubMedID 14990792)
40

Data Source:
HPRD (in vitro)

		KLRB1	CLEC2D
Description		killer cell lectin like receptor B1	C-type lectin domain family 2 member D
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Signaling Receptor Activity	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity	Cell Surface Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Obesity (extreme) ( 31888951)	Autoimmune thyroid disease ( 32581359) HDL cholesterol levels x short total sleep time interaction (1df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Multiple sclerosis ( 31604244)
Interacting Genes		2 interacting genes: CLEC2D PTPN6	33 interacting genes: ADIPOQ ATP6V0C B3GALT5 BRICD5 CD68 CLDN19 CLDN2 CLEC2A CLRN2 CXCL9 DEFB121 ENTPD8 ERMP1 FAM3C FNDC9 GPR42 IL1RL1 KLRB1 KLRC1 LEPROTL1 NKG7 PLLP PLN PLP1 RPRM SEC22A SHMT2 SYT15 SYT15B TM4SF18 TMEM190 TMEM80 TSPAN4
Entrez ID		3820	29121
HPRD ID		04201	16134
Ensembl ID		ENSG00000111796	ENSG00000069493
Uniprot IDs		Q12918	Q9UHP7 W8JXM2
PDB IDs		5MGR 5MGS 5MGT	4QKG 4QKH 4QKI 4QKJ 4WCO 5MGT
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Regulation Of Inflammatory Response To Wounding Phosphorylation-dependent Protein Binding Negative Regulation Of Mast Cell Activation Inflammatory Response To Wounding Regulation Of Neutrophil Activation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin CD27 Signaling Pathway Alpha-beta T Cell Receptor Complex Neutrophil Activation Involved In Immune Response Negative Regulation Of Mast Cell Activation Involved In Immune Response Epididymis Development Negative Regulation Of Inflammatory Response To Wounding Negative Regulation Of B Cell Receptor Signaling Pathway Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Mast Cell Activation Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Regulation Of B Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Tertiary Granule Lumen Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Phosphotyrosine Residue Binding Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Interleukin-6 Production B Cell Receptor Signaling Pathway T Cell Costimulation Platelet Aggregation Regulation Of B Cell Differentiation Natural Killer Cell Mediated Immunity SH2 Domain Binding Regulation Of Humoral Immune Response Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin Specific Granule Lumen Myeloid Cell Development Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Homotypic Cell-cell Adhesion Negative Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Negative Regulation Of Adaptive Immune Response	Membrane Paracellular Transport Paracellular Tight Junction Channel Activity Defense Response Structural Constituent Of Myelin Sheath
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