KLRB1

Description		killer cell lectin like receptor B1
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GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Carbohydrate Binding Signaling Receptor Activity
	Biological Process	Cell Surface Receptor Signaling Pathway Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Obesity (extreme) ( 31888951)
Interacting Genes		2 interacting genes: CLEC2D PTPN6
Entrez ID		3820
HPRD ID		04201
Ensembl ID		ENSG00000111796
Uniprot IDs		Q12918
PDB IDs		5MGR 5MGS 5MGT
Enriched GO Terms of Interacting Partners?		Non-membrane Spanning Protein Tyrosine Phosphatase Activity Negative Regulation Of Neutrophil Activation Regulation Of Inflammatory Response To Wounding Phosphorylation-dependent Protein Binding Negative Regulation Of Mast Cell Activation Inflammatory Response To Wounding Regulation Of Neutrophil Activation Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin CD27 Signaling Pathway Alpha-beta T Cell Receptor Complex Neutrophil Activation Involved In Immune Response Negative Regulation Of Mast Cell Activation Involved In Immune Response Epididymis Development Negative Regulation Of Inflammatory Response To Wounding Negative Regulation Of B Cell Receptor Signaling Pathway Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Transmembrane Receptor Protein Tyrosine Phosphatase Activity Regulation Of Mast Cell Activation Positive Regulation Of Cell Adhesion Mediated By Integrin Peptidyl-tyrosine Dephosphorylation Platelet Formation Megakaryocyte Development Regulation Of B Cell Receptor Signaling Pathway Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Negative Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Cytokine Production Involved In Inflammatory Response Tertiary Granule Lumen Regulation Of Type I Interferon-mediated Signaling Pathway Regulation Of T Cell Receptor Signaling Pathway Phosphotyrosine Residue Binding Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Interleukin-6 Production B Cell Receptor Signaling Pathway T Cell Costimulation Platelet Aggregation Regulation Of B Cell Differentiation Natural Killer Cell Mediated Immunity SH2 Domain Binding Regulation Of Humoral Immune Response Peptidyl-tyrosine Phosphorylation Regulation Of Cell Adhesion Mediated By Integrin Specific Granule Lumen Myeloid Cell Development Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Homotypic Cell-cell Adhesion Negative Regulation Of Tumor Necrosis Factor Production T Cell Proliferation Negative Regulation Of Adaptive Immune Response
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