CLCA1 and KCNMB1

Number of citations of the paper that reports this interaction (PubMedID 11994272)
0

Data Source:
HPRD (in vivo)

		CLCA1	KCNMB1
Description		chloride channel accessory 1	potassium calcium-activated channel subfamily M regulatory beta subunit 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Microvillus Membrane Secretory Granule Zymogen Granule Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Synapse
	Molecular Function	Metalloendopeptidase Activity Intracellularly Calcium-gated Chloride Channel Activity Chloride Channel Activity Peptidase Activity Metallopeptidase Activity Hydrolase Activity Metal Ion Binding	Protein Binding Calcium-activated Potassium Channel Activity Potassium Channel Regulator Activity
	Biological Process	Proteolysis Monoatomic Ion Transport Calcium Ion Transport Chloride Transport Monoatomic Ion Transmembrane Transport Cellular Response To Hypoxia Chloride Transmembrane Transport	Detection Of Calcium Ion Monoatomic Ion Transport Potassium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Stimuli-sensing channels	Ca2+ activated K+ channels cGMP effects Sensory processing of sound by inner hair cells of the cochlea Acetylcholine inhibits contraction of outer hair cells
Drugs			Procaine Ritodrine Nitrendipine Miconazole Colforsin Trimebutine
Diseases
GWAS			Acne (severe) ( 24927181) Liver transplant-free survival in primary sclerosing cholangitis (time to event) ( 28779025)
Interacting Genes		2 interacting genes: ITGB4 KCNMB1	5 interacting genes: CLCA1 EWSR1 KCNMA1 MT-CO1 STX8
Entrez ID		1179	3779
HPRD ID		04880	10358
Ensembl ID		ENSG00000016490	ENSG00000145936
Uniprot IDs		A8K7I4	Q16558
PDB IDs		6PYO 6PYX
Enriched GO Terms of Interacting Partners?		Hemidesmosome Assembly Hemidesmosome Skin Morphogenesis Myelin Assembly Cell Communication Nail Development Peripheral Nervous System Myelin Formation Insulin-like Growth Factor I Binding Neuregulin Binding Mesodermal Cell Differentiation Trophoblast Cell Migration Detection Of Calcium Ion Calcium-activated Potassium Channel Activity Myelination In Peripheral Nervous System Filopodium Assembly Integrin Complex Cell Adhesion Mediated By Integrin Cell-substrate Junction Organization Cell-substrate Junction Assembly Potassium Channel Regulator Activity Cell Leading Edge Basal Plasma Membrane G Protein-coupled Receptor Binding Voltage-gated Potassium Channel Complex Basement Membrane Myelination Axon Ensheathment Integrin-mediated Signaling Pathway Cell-matrix Adhesion Detection Of Chemical Stimulus Ameboidal-type Cell Migration Response To Calcium Ion	Response To Decreased Oxygen Levels Response To Oxygen Levels Response To Hypoxia Large Conductance Calcium-activated Potassium Channel Activity Monoatomic Cation Transport Inorganic Ion Transmembrane Transport Monoatomic Ion Transmembrane Transport Response To Carbon Monoxide Smooth Muscle Contraction Involved In Micturition Micturition Monoatomic Ion Transport Negative Regulation Of Cell Volume Chloride Channel Inhibitor Activity Urinary Bladder Smooth Muscle Contraction Transmembrane Transport Calcium-activated Potassium Channel Activity Response To Metal Ion Cytochrome-c Oxidase Activity Intracellularly Calcium-gated Chloride Channel Activity Zymogen Granule Membrane Mitochondrial Electron Transport, Cytochrome C To Oxygen Intracellular Potassium Ion Homeostasis Respiratory Chain Complex IV Oxidative Phosphorylation Early Endosome To Late Endosome Transport
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