IGHG4 and BAG5

Data Source: HiPPIP (Novel)

		IGHG4	BAG5
Name		immunoglobulin heavy constant gamma 4 (G4m marker)	BAG cochaperone 5
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane Immunoglobulin Complex Immunoglobulin Complex, Circulating Extracellular Exosome IgG Immunoglobulin Complex Blood Microparticle	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Inclusion Body Junctional Membrane Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Antigen Binding Immunoglobulin Receptor Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Protein-folding Chaperone Binding Ubiquitin Ligase Inhibitor Activity
	Biological Process	Adaptive Immune Response Immune System Process Complement Activation, Classical Pathway Antibacterial Humoral Response B Cell Receptor Signaling Pathway	Protein Folding Golgi Organization Negative Regulation Of Neuron Projection Development Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Stabilization Negative Regulation Of Protein Refolding Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Pathways		None	Regulation of HSF1-mediated heat shock response
GWAS		No GWAS studies recorded	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Body mass index ( 26426971 ) Brain morphology (MOSTest) ( 32665545 ) Broad depression or schizophrenia ( 30626913 ) Depression ( 29700475 ) Schizophrenia ( 25056061 )
Novel Interactors		1 novel interactors: BAG5	5 novel interactors: ANXA3 ATP5MJ IGHG4 JMJD6 SIVA1
Interacting Genes		None recorded	19 interacting genes: BANP CDCA7L CIRBP CREBBP DES EFEMP1 FAM118B GOLGA6A KASH5 KRTAP5-4 LRRK1 PINK1 PRKN SNCA STUB1 THAP1 TP53 TRIM27 VCP
Entrez ID		3503	9529
HPRD ID		11757	04862
Ensembl ID		ENSG00000211892	ENSG00000166170
Uniprot IDs		Not available	A0A024R6M6 Q9UL15
PDB IDs		Not available	2D9D 3A8Y
GO Terms Enriched among Interactors		Negative Regulation Of Protein Refolding Junctional Membrane Complex Negative Regulation Of Protein Folding Regulation Of Protein Folding Ubiquitin Ligase Inhibitor Activity Adenyl-nucleotide Exchange Factor Activity Inclusion Body Regulation Of Inclusion Body Assembly Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Protein Ubiquitination Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Negative Regulation Of Post-translational Protein Modification Protein-folding Chaperone Binding Golgi Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Catabolic Process Negative Regulation Of Neuron Projection Development Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteolysis Protein Folding Regulation Of Protein Ubiquitination Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Cell Projection Organization Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Protein Stabilization Regulation Of Post-translational Protein Modification Ubiquitin Protein Ligase Binding Regulation Of Protein Catabolic Process Regulation Of Protein Stability Negative Regulation Of Catabolic Process Regulation Of Proteolysis Regulation Of Apoptotic Signaling Pathway	Regulation Of Mitophagy Regulation Of Autophagy Of Mitochondrion Positive Regulation Of ATP Biosynthetic Process Identical Protein Binding Dopamine Transport Regulation Of Purine Nucleotide Metabolic Process Mitochondrion To Lysosome Vesicle-mediated Transport Positive Regulation Of Mitophagy Cellular Response To Hydrogen Sulfide Regulation Of ATP Biosynthetic Process Regulation Of Dopamine Secretion Regulation Of Oxidative Phosphorylation Cellular Response To Topologically Incorrect Protein Positive Regulation Of Autophagy Of Mitochondrion Regulation Of Aerobic Respiration Positive Regulation Of Protein-containing Complex Assembly Monoamine Transport Regulation Of Protein Stability Regulation Of Autophagy Response To Hydrogen Sulfide Negative Regulation Of Autophagy Protein Stabilization Negative Regulation Of Mitochondrial Fission Positive Regulation Of ATP Metabolic Process Regulation Of Mitochondrion Organization Regulation Of Synaptic Vesicle Transport Regulation Of Catecholamine Secretion Negative Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Protein-containing Complex Assembly Lewy Body Dopamine Uptake Involved In Synaptic Transmission Mitochondrion Organization Positive Regulation Of Mitochondrial Membrane Potential Aggresome Assembly Regulation Of Cellular Respiration Regulation Of Release Of Cytochrome C From Mitochondria Tau Protein Binding Positive Regulation Of Post-translational Protein Modification Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Reactive Oxygen Species Metabolic Process Hsp70 Protein Binding Autophagy Ubiquitin Protein Ligase Binding Positive Regulation Of Organelle Organization Macroautophagy Inclusion Body Assembly Positive Regulation Of Small Molecule Metabolic Process Mitophagy Fibrillar Center Protein Destabilization