ZC3H12D and ZC3H12A

Number of citations of the paper that reports this interaction (PubMedID 26134560)
38

Data Source:
BioGRID (two hybrid)

		ZC3H12D	ZC3H12A
Description		zinc finger CCCH-type containing 12D	zinc finger CCCH-type containing 12A
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Cytoplasmic Ribonucleoprotein Granule	P-body Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytoskeleton Membrane Rough Endoplasmic Reticulum Membrane Protein-containing Complex Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	MRNA Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity Protein Binding Zinc Ion Binding Hydrolase Activity Metal Ion Binding	DNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Nuclease Activity Endonuclease Activity RNA Endonuclease Activity RNA Exonuclease Activity RNA Nuclease Activity Cysteine-type Deubiquitinase Activity Protein Binding Zinc Ion Binding Hydrolase Activity MiRNA Binding RNA Stem-loop Binding MRNA 3'-UTR AU-rich Region Binding Ribosome Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Cell Growth 3'-UTR-mediated MRNA Destabilization Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Angiogenesis Negative Regulation Of Protein Phosphorylation Positive Regulation Of Defense Response To Virus By Host Immune System Process Immune Response-activating Signaling Pathway MRNA Catabolic Process Apoptotic Process Inflammatory Response DNA Damage Response Nervous System Development Regulation Of Gene Expression Positive Regulation Of Autophagy MiRNA Catabolic Process Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Lipid Storage Protein Deubiquitination Cell Differentiation Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Cellular Response To Oxidative Stress Cellular Response To Glucose Starvation Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Macrophage Activation Negative Regulation Of Canonical NF-kappaB Signal Transduction Host-mediated Suppression Of Viral Genome Replication Negative Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Protein Complex Oligomerization Defense Response To Virus Negative Regulation Of Cardiac Muscle Contraction Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Virus Negative Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of P38MAPK Cascade Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Deubiquitination Cellular Response To Sodium Arsenite Cellular Response To Ionomycin Cellular Response To Chemokine Negative Regulation Of T-helper 17 Cell Differentiation Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of MiRNA Catabolic Process
Pathways			Regulation of CDH19 Expression and Function
Drugs
Diseases
GWAS		Asthma ( 32296059) Dupuytren's disease ( 21732829 28886342) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494)	Eyebrow thickness ( 26926045) Mean corpuscular hemoglobin ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		1 interacting genes: ZC3H12A	19 interacting genes: AHSP AIMP2 BTRC CYFIP2 DNAJB13 EP300 HIF1A IKBKG IL6 IRAK2 KPNA2 P4HA3 SHBG SMAD3 TANK TRIM55 TRIM63 UBC ZC3H12D
Entrez ID		340152	80149
HPRD ID		19272	08021
Ensembl ID		ENSG00000178199	ENSG00000163874
Uniprot IDs		A2A288	A0A1W2PQC8 Q5D1E8
PDB IDs			3V32 3V33 3V34
Enriched GO Terms of Interacting Partners?		P-body Nuclear Matrix Organization Cytoskeleton-nuclear Membrane Anchor Activity Nuclear Matrix Anchoring At Nuclear Membrane Cellular Response To Sodium Arsenite Positive Regulation Of Protein Deubiquitination Cellular Response To Salt Response To Sodium Arsenite Positive Regulation Of MiRNA Catabolic Process Negative Regulation Of Cardiac Muscle Contraction Cellular Response To Ionomycin Meiotic Nuclear Membrane Microtubule Tethering Complex Lamin Binding Regulation Of Protein Deubiquitination Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of T-helper 17 Cell Differentiation Cellular Response To Chemokine Rough Endoplasmic Reticulum Membrane Negative Regulation Of Macrophage Activation Host-mediated Suppression Of Viral Genome Replication RNA Stem-loop Binding Negative Regulation Of Striated Muscle Contraction MiRNA Catabolic Process RNA Exonuclease Activity Cellular Response To Arsenic-containing Substance Cellular Response To Ether Negative Regulation Of T-helper 17 Type Immune Response 3'-UTR-mediated MRNA Destabilization Negative Regulation Of Heart Contraction Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Lipid Storage Negative Regulation Of T-helper Cell Differentiation Negative Regulation Of Muscle Contraction Negative Regulation Of Blood Circulation MiRNA Metabolic Process Response To Ether Response To Salt Maintenance Of Protein Location In Nucleus Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of P38MAPK Cascade Regulation Of T-helper 17 Cell Differentiation MRNA 3'-UTR AU-rich Region Binding RNA Nuclease Activity Response To Arsenic-containing Substance Negative Regulation Of Alpha-beta T Cell Differentiation Nuclear Outer Membrane Negative Regulation Of Interleukin-1 Beta Production Positive Regulation Of Defense Response To Virus By Host Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Negative Regulation Of Interleukin-1 Production	Canonical NF-kappaB Signal Transduction Response To Interleukin-1 Non-canonical NF-kappaB Signal Transduction Apoptotic Process Regulation Of Glycolytic Process Intracellular Signaling Cassette Regulation Of Protein Metabolic Process Nuclear Receptor Binding Positive Regulation Of Signal Transduction Transcription Coactivator Binding Ubiquitin Protein Ligase Binding Vascular Endothelial Growth Factor Production Positive Regulation Of MiRNA Transcription Regulation Of Transforming Growth Factor Beta2 Production Regulation Of Carbohydrate Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Programmed Cell Death Cell Death Positive Regulation Of MiRNA Metabolic Process Regulation Of Cytokine-mediated Signaling Pathway Response To Virus Hemoglobin Metabolic Process Positive Regulation Of Proteolysis Regulation Of ATP Metabolic Process Immune System Process Cellular Response To Virus Regulation Of MiRNA Transcription T-helper 17 Cell Lineage Commitment TOR Signaling Regulation Of Purine Nucleotide Metabolic Process Regulation Of Intracellular Signal Transduction Response To Other Organism Regulation Of MiRNA Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Cytoplasm DNA-binding Transcription Repressor Activity T-helper Cell Lineage Commitment Positive Regulation Of Protein Metabolic Process Beta-catenin Binding Positive Regulation Of Cytokine Production Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of Gene Expression Immune Response-regulating Cell Surface Receptor Signaling Pathway CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment Positive Regulation Of Catabolic Process Positive Regulation Of Metabolic Process
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