HTN3 and MUC7

Number of citations: 46 (PubMedID 26544073)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vitro)

		HTN3	MUC7
Name		histatin 3	mucin 7, secreted
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrion	Extracellular Region Golgi Lumen Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity	Protein Binding
	Biological Process	Immune System Process Biomineral Tissue Development Killing Of Cells Of Another Organism Defense Response To Bacterium Innate Immune Response Positive Regulation Of Fibroblast Proliferation Defense Response To Fungus Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing	Killing Of Cells Of Another Organism Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Antimicrobial peptides	Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
GWAS		No GWAS studies recorded	Diabetic nephropathy in type 1 diabetes ( 31537649 )
Interacting Genes		3 interacting genes: DNAJB11 HSPA8 MUC7	8 interacting genes: AMY1A GALNT10 GALNT12 GALNT14 HTN3 LTF PCGF1 SELL
Entrez ID		3347	4589
HPRD ID		00815	11759
Ensembl ID		ENSG00000205649	ENSG00000171195
Uniprot IDs		P15516	Q8TAX7
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Protein Folding Chaperone Complex Chaperone-mediated Autophagy Translocation Complex Disassembly Unfolded Protein Binding Protein Folding Lumenal Side Of Lysosomal Membrane Regulation Of Protein Import C3HC4-type RING Finger Domain Binding ATP-dependent Protein Disaggregase Activity Vesicle Uncoating Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Clathrin Coat Disassembly Chaperone-mediated Autophagy Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Endoplasmic Reticulum Chaperone Complex Protein Targeting To Vacuole Involved In Autophagy Prp19 Complex Regulation Of Protein Complex Stability Negative Regulation Of NLRP3 Inflammasome Complex Assembly Misfolded Protein Binding MRNA Modification Positive Regulation Of ATP-dependent Activity MRNA Metabolic Process	Polypeptide N-acetylgalactosaminyltransferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Carbohydrate Binding Metal Ion Binding Protein O-linked Glycosylation Protein Glycosylation Macromolecule Glycosylation Glycosylation Glycosyltransferase Activity Glycoprotein Biosynthetic Process Glycoprotein Metabolic Process Defense Response To Fungus Response To Fungus Negative Regulation Of Tumor Necrosis Factor (ligand) Superfamily Member 11 Production Alpha-amylase Activity Negative Regulation Of Single-species Biofilm Formation In Or On Host Organism Carbohydrate Derivative Biosynthetic Process Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Killing Of Cells Of Another Organism Positive Regulation Of Bone Mineralization Involved In Bone Maturation Phagocytic Vesicle Lumen Membrane Destabilizing Activity Antimicrobial Humoral Response Heparin Binding Negative Regulation Of Osteoclast Development Golgi Membrane Extracellular Space Glycosphingolipid Binding Cell Killing Positive Regulation Of Chondrocyte Proliferation Regulation Of Osteoclast Development Carbohydrate Derivative Metabolic Process Cytolysis By Host Of Symbiont Cells Antifungal Humoral Response Chloride Ion Binding Humoral Immune Response Negative Regulation Of ATP-dependent Activity Negative Regulation Of Membrane Potential Negative Regulation Of Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Osteoblast Proliferation Oligosaccharide Binding Specific Granule Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Cation Binding Host-mediated Suppression Of Viral Proces Defense Response To Bacterium