HSD3B1 and SLC16A13

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		HSD3B1	SLC16A13
Name		hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	solute carrier family 16 member 13
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cilium Microtubule Cytoskeleton Membrane Smooth Endoplasmic Reticulum Membrane Mitochondrial Membrane Intracellular Membrane-bounded Organelle Intercellular Bridge	Golgi Membrane Golgi Apparatus Cytosol Plasma Membrane Membrane
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Catalytic Activity 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Steroid Delta-isomerase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Isomerase Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity	Protein Binding Monocarboxylic Acid Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Progesterone Biosynthetic Process Androgen Biosynthetic Process Estrogen Biosynthetic Process Steroid Metabolic Process C21-steroid Hormone Metabolic Process	Monocarboxylic Acid Transport Transmembrane Transport
Pathways		Androgen biosynthesis Mineralocorticoid biosynthesis Glucocorticoid biosynthesis	None
Drugs		NADH Trilostane Androstenedione Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate	None
GWAS		Diisocyanate-induced asthma ( 25918132 )	Type 2 diabetes ( 23945395 24390345 26818947 )
Interacting Genes		3 interacting genes: AQP6 SLC16A13 TMEM14B	19 interacting genes: AQP6 ATP13A1 BSG CCNDBP1 CD79A CREB3L1 FAM210B FXYD6-FXYD2 GJA8 HSD3B1 JPH1 PGRMC2 PTPN9 SHISAL1 SLC10A1 SYNDIG1 TMEM14B TMEM160 TMEM50B
Entrez ID		3283	201232
HPRD ID		04920	18054
Ensembl ID		ENSG00000203857	ENSG00000174327
Uniprot IDs		P14060	Q7RTY0
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Monoatomic Anion Channel Activity Ammonium Transmembrane Transport Ammonium Channel Activity Renal Water Transport Water Channel Activity Carbon Dioxide Transport Monocarboxylic Acid Transmembrane Transporter Activity One-carbon Compound Transport Water Transport Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Fluid Transport Heme Metabolic Process Channel Activity Porphyrin-containing Compound Metabolic Process Tetrapyrrole Metabolic Process Pigment Metabolic Process Transmembrane Transport Cerebral Cortex Development Chloride Transmembrane Transport Odontogenesis Neural Precursor Cell Proliferation Symporter Activity Chloride Transport	None