HSD3B1

Description		hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cilium Microtubule Cytoskeleton Membrane Smooth Endoplasmic Reticulum Membrane Mitochondrial Membrane Intracellular Membrane-bounded Organelle Intercellular Bridge
	Molecular Function	3-beta-hydroxysteroid 3-dehydrogenase (NADP+) Activity Catalytic Activity 3-beta-hydroxy-Delta5-steroid Dehydrogenase (NAD+) Activity Steroid Delta-isomerase Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Isomerase Activity 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity
	Biological Process	Lipid Metabolic Process Steroid Biosynthetic Process Progesterone Biosynthetic Process Androgen Biosynthetic Process Estrogen Biosynthetic Process Steroid Metabolic Process C21-steroid Hormone Metabolic Process
Pathways		Androgen biosynthesis Mineralocorticoid biosynthesis Glucocorticoid biosynthesis
Drugs		NADH Trilostane Androstenedione Hydrocortisone aceponate Hydrocortisone acetate Hydrocortisone butyrate Hydrocortisone cypionate Hydrocortisone phosphate Hydrocortisone probutate Hydrocortisone valerate
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)
Interacting Genes		3 interacting genes: AQP6 SLC16A13 TMEM14B
Entrez ID		3283
HPRD ID		04920
Ensembl ID		ENSG00000203857
Uniprot IDs		P14060
PDB IDs
Enriched GO Terms of Interacting Partners?		PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Carbon Dioxide Transmembrane Transporter Activity Carbon Dioxide Transmembrane Transport Monoatomic Anion Channel Activity Ammonium Transmembrane Transport Ammonium Channel Activity Renal Water Transport Water Channel Activity Carbon Dioxide Transport Monocarboxylic Acid Transmembrane Transporter Activity One-carbon Compound Transport Water Transport Tetrapyrrole Biosynthetic Process Porphyrin-containing Compound Biosynthetic Process Heme Biosynthetic Process Fluid Transport Heme Metabolic Process Channel Activity Porphyrin-containing Compound Metabolic Process Tetrapyrrole Metabolic Process Pigment Metabolic Process Transmembrane Transport Cerebral Cortex Development Chloride Transmembrane Transport Odontogenesis Neural Precursor Cell Proliferation Symporter Activity Chloride Transport
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