HRC and TRDN

Number of citations of the paper that reports this interaction (PubMedID 11504710)
0

Data Source:
HPRD (in vitro, in vivo)

		HRC	TRDN
Description		histidine rich calcium binding protein	triadin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Cytosol Sarcoplasmic Reticulum Z Disc Sarcoplasmic Reticulum Lumen	Nucleoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Junctional Membrane Complex Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen
	Molecular Function	Calcium Ion Binding Protein Binding Transmembrane Transporter Binding ATPase Binding	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Transmembrane Transporter Binding
	Biological Process	Regulation Of Heart Rate Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Heart Contraction Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Relaxation Of Cardiac Muscle Regulation Of Calcium Ion Transmembrane Transport	Intracellular Calcium Ion Homeostasis Muscle Contraction Response To Bacterium Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Cytoplasmic Microtubule Organization Regulation Of Sequestering Of Calcium Ion Establishment Of Localization In Cell Heart Contraction Regulation Of Cardiac Muscle Cell Membrane Potential Endoplasmic Reticulum Membrane Organization Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction
Pathways		Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Stimuli-sensing channels Ion homeostasis
Drugs
Diseases
GWAS			Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Borderline personality disorder ( 28632202) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Intraocular pressure ( 30591961) Metabolite levels ( 23823483) Nickel levels ( 26025379) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)
Interacting Genes		2 interacting genes: TRDN ZNF699	10 interacting genes: ASPH CALM1 CASQ1 CASQ2 HRC KCNE4 PPIB PTPRN RYR1 SOCS3
Entrez ID		3270	10345
HPRD ID		00818	04474
Ensembl ID		ENSG00000130528	ENSG00000186439
Uniprot IDs		P23327	A0A590UJV0 H9ME53 Q13061 Q8IVK2
PDB IDs
Enriched GO Terms of Interacting Partners?		Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Positive Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Sarcoplasmic Reticulum Lumen Positive Regulation Of Cell Communication By Electrical Coupling Junctional Sarcoplasmic Reticulum Membrane Regulation Of Cardiac Muscle Cell Membrane Potential Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Junctional Membrane Complex Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Cell Communication By Electrical Coupling Sarcoplasmic Reticulum Calcium Ion Transport Endoplasmic Reticulum Membrane Organization Heart Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Heart Process Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Sarcoplasmic Reticulum Membrane Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Sequestering Of Calcium Ion Cytoplasmic Microtubule Organization Sarcoplasmic Reticulum	Sarcoplasmic Reticulum Lumen Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Sequestering Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Calcium-mediated Signaling Sarcoplasmic Reticulum Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Calcium Channel Complex Regulation Of Striated Muscle Contraction Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Sarcoplasmic Reticulum Membrane Regulation Of Calcium Ion Transmembrane Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Muscle Contraction Regulation Of Heart Contraction Detection Of Calcium Ion Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Muscle System Process Regulation Of Blood Circulation Smooth Endoplasmic Reticulum Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of System Process Regulation Of Heart Rate Regulation Of Monoatomic Ion Transmembrane Transport Calcium Ion Binding Regulation Of Metal Ion Transport Response To Calcium Ion Z Disc Transmembrane Transporter Binding Regulation Of Monoatomic Ion Transport Terminal Cisterna Intracellular Signaling Cassette Intracellular Calcium Ion Homeostasis Muscle Contraction Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Store-operated Calcium Channel Activity Calcium Ion Homeostasis Muscle System Process Intracellular Signal Transduction Regulation Of Monoatomic Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Cellular Response To Caffeine Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Purine-containing Compound Response To Metal Ion Response To Caffeine Detection Of Chemical Stimulus Intracellular Monoatomic Cation Homeostasis
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