HOXB2 and NDOR1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HOXB2	NDOR1
Description		homeobox B2	NADPH dependent diflavin oxidoreductase 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	NADPH-hemoprotein Reductase Activity Protein Binding Electron Transfer Activity FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On NAD(P)H Oxidoreductase Activity, Acting On NAD(P)H, Heme Protein As Acceptor Flavin Adenine Dinucleotide Binding NADP Binding NADPH Binding FAD Binding NADPH-iron-sulfur [2Fe-2S] Protein Oxidoreductase Activity
	Biological Process	Morphogenesis Of An Epithelial Sheet Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Nervous System Development Anterior/posterior Pattern Specification Dorsal/ventral Pattern Formation Rhombomere 3 Development Rhombomere 4 Development Facial Nerve Structural Organization Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Skeletal System Morphogenesis Neural Nucleus Development	Iron-sulfur Cluster Assembly Electron Transport Chain
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	Cytosolic iron-sulfur cluster assembly
Drugs
Diseases
GWAS		Body mass index ( 26426971) Experiencing mood swings ( 29500382) Feeling hurt ( 29500382) Keratoconus ( 33649486) Primary tooth development (number of teeth) ( 20195514)	Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular hemoglobin concentration ( 27863252 32888494) Mean corpuscular volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell count ( 32888494) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		13 interacting genes: CREBBP DTX2 EP300 MID2 MNDA MORN3 NDOR1 PBX4 RCHY1 RUNX1T1 SOD1 UBASH3B ZNF410	29 interacting genes: C7orf57 CCDC33 CENATAC CYCS DLG4 DRC4 EFHC2 ENOX2 GPS2 HOXB2 KIAA0408 LMO2 LMO3 LNX1 MEOX1 MTUS2 NAB2 NLK PSMB6 TCF4 TCHP TEPSIN TLE5 UBQLN1 UBQLN2 ZBTB42 ZC2HC1C ZNF620 ZNF774
Entrez ID		3212	27158
HPRD ID		00854	10444
Ensembl ID		ENSG00000173917	ENSG00000188566
Uniprot IDs		P14652	Q9UHB4
PDB IDs			4H2D
Enriched GO Terms of Interacting Partners?		Histone H3K18 Acetyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K27 Acetyltransferase Activity Peptide Lactyltransferase (CoA-dependent) Activity Zinc Ion Binding P53 Binding N-terminal Protein Amino Acid Acetylation Peptidyl-lysine Acetylation Nucleus Regulation Of Cellular Response To Heat Acetyltransferase Activity Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Transcription Coregulator Activity Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Histone Acetyltransferase Activity Protein Acetylation DNA-binding Transcription Factor Binding Phosphoprotein Binding Activation Of Innate Immune Response Tau Protein Binding Transcription Coactivator Binding Immune Response-activating Cell Surface Receptor Signaling Pathway Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity NADPH-iron-sulfur [2Fe-2S] Protein Oxidoreductase Activity Protein Destabilization Canonical NF-kappaB Signal Transduction Damaged DNA Binding Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Cell Activation Transcription Coactivator Activity Positive Regulation Of Innate Immune Response Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Peptide Crotonyltransferase Activity Response To Antipsychotic Drug Action Potential Initiation
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