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HLA-DRB5 and HLA-DRA
Number of citations of the paper that reports this interaction (PMID
12244309
)
70
Data Source:
HPRD
(in vitro)
HLA-DRB5
HLA-DRA
Gene Name
major histocompatibility complex, class II, DR beta 5
major histocompatibility complex, class II, DR alpha
Image
Gene Ontology Annotations
Cellular Component
Golgi Membrane
Extracellular Space
Lysosomal Membrane
Plasma Membrane
External Side Of Plasma Membrane
ER To Golgi Transport Vesicle Membrane
Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Late Endosome Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Golgi Membrane
Lysosome
Lysosomal Membrane
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Surface
ER To Golgi Transport Vesicle Membrane
Transport Vesicle Membrane
Endocytic Vesicle Membrane
Clathrin-coated Endocytic Vesicle Membrane
Late Endosome Membrane
Trans-Golgi Network Membrane
MHC Class II Protein Complex
Extracellular Vesicular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Molecular Function
Peptide Antigen Binding
MHC Class II Protein Complex Binding
MHC Class II Receptor Activity
Peptide Antigen Binding
Biological Process
Immunoglobulin Production Involved In Immunoglobulin Mediated Immune Response
Inflammatory Response To Antigenic Stimulus
Humoral Immune Response Mediated By Circulating Immunoglobulin
Immune Response
Detection Of Bacterium
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
Regulation Of Interleukin-4 Production
Negative Regulation Of Interferon-gamma Production
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
T-helper 1 Type Immune Response
Negative Regulation Of T Cell Proliferation
T Cell Receptor Signaling Pathway
Protein Tetramerization
Interferon-gamma-mediated Signaling Pathway
Regulation Of Interleukin-10 Secretion
Peptide Antigen Assembly With MHC Class II Protein Complex
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Polysaccharide Assembly With MHC Class II Protein Complex
Immune Response
Cytokine-mediated Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
T Cell Costimulation
T Cell Receptor Signaling Pathway
Cognition
Interferon-gamma-mediated Signaling Pathway
Pathways
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Generation of second messenger molecules
Downstream TCR signaling
Costimulation by the CD28 family
Translocation of ZAP-70 to Immunological synapse
Interferon Signaling
Cytokine Signaling in Immune system
Interferon gamma signaling
TCR signaling
MHC class II antigen presentation
PD-1 signaling
Phosphorylation of CD3 and TCR zeta chains
Adaptive Immune System
Drugs
Diseases
GWAS
Chronic lymphocytic leukemia (
21131588
)
Hypothyroidism (
22493691
)
Lymphoma (
23349640
)
Parkinson's disease (
21292315
)
Prostate cancer (
23535732
)
Ulcerative colitis (
21297633
19122664
)
Anti-cyclic Citrullinated Peptide Antibody (
19287509
)
Asthma (
23028483
21804548
)
Complement C3 and C4 levels (
23028341
)
Cystic fibrosis severity (
21602797
)
Hodgkin's lymphoma (
21037568
22286212
)
Lymphoma (
23349640
)
Multiple sclerosis (
17660530
)
Multiple sclerosis (OCB status) (
23472185
)
Non-obstructive azoospermia (
22541561
)
Parkinson's disease (
20711177
)
Prostate cancer (
23535732
)
Pubertal anthropometrics (
23449627
)
Rheumatoid arthritis (
21653640
)
Systemic sclerosis (
21779181
)
Ulcerative colitis (
23128233
20228798
18836448
21297633
19122664
)
Vitiligo (
20410501
)
Protein-Protein Interactions
2 interactors:
CTAG1B
HLA-DRA
10 interactors:
CD63
CD74
CD82
HLA-DMA
HLA-DMB
HLA-DRB1
HLA-DRB5
MARCH1
MBP
PRPF40B
Entrez ID
3127
3122
HPRD ID
09209
00833
Ensembl ID
ENSG00000198502
ENSG00000204287
Uniprot IDs
Q30154
P01903
Q30118
PDB IDs
1FV1
1H15
1HQR
1ZGL
1A6A
1AQD
1BX2
1D5M
1D5X
1D5Z
1D6E
1DLH
1FV1
1FYT
1H15
1HQR
1HXY
1J8H
1JWM
1JWS
1JWU
1KG0
1KLG
1KLU
1LO5
1PYW
1R5I
1SEB
1SJE
1SJH
1T5W
1T5X
1YMM
1ZGL
2FSE
2G9H
2IAM
2IAN
2ICW
2IPK
2OJE
2Q6W
2SEB
2WBJ
2XN9
3C5J
3L6F
3O6F
3PDO
3PGC
3PGD
3QXA
3QXD
3S4S
3S5L
3T0E
4AEN
4AH2
4E41
4FQX
4GBX
4H1L
Enriched GO Terms of Interacting Partners
?
Polysaccharide Assembly With MHC Class II Protein Complex
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
T Cell Costimulation
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
T Cell Receptor Signaling Pathway
Interferon-gamma-mediated Signaling Pathway
Antigen Receptor-mediated Signaling Pathway
Cellular Response To Interferon-gamma
Response To Interferon-gamma
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Antigen Processing And Presentation Of Peptide Antigen
Positive Regulation Of Cell-cell Adhesion
Immune Response-activating Cell Surface Receptor Signaling Pathway
Antigen Processing And Presentation
Cognition
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Cellular Protein Complex Assembly
Regulation Of Cell-cell Adhesion
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Cytokine-mediated Signaling Pathway
Immune Response-regulating Signaling Pathway
Regulation Of Cell Activation
Cellular Response To Cytokine Stimulus
Regulation Of Cell Adhesion
Cellular Macromolecular Complex Assembly
Positive Regulation Of Immune Response
Response To Cytokine
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Antigen Processing And Presentation Of Peptide Antigen
Peptide Antigen Assembly With MHC Class II Protein Complex
MHC Class II Protein Complex Assembly
Antigen Processing And Presentation
Positive Regulation Of T Cell Activation
Positive Regulation Of Homotypic Cell-cell Adhesion
Positive Regulation Of Cell-cell Adhesion
Regulation Of T Cell Activation
Positive Regulation Of Cell Activation
Immune Response
Regulation Of Cell-cell Adhesion
Positive Regulation Of Cell Adhesion
Regulation Of Lymphocyte Activation
Regulation Of Cell Activation
Regulation Of Cell Adhesion
Positive Regulation Of Immune Response
Immune System Process
Positive Thymic T Cell Selection
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Thymic T Cell Selection
Immunoglobulin Mediated Immune Response
B Cell Mediated Immunity
Chaperone Mediated Protein Folding Requiring Cofactor
Positive T Cell Selection
Regulation Of Immune System Process
Regulation Of Interleukin-4 Production
Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains
Response To Cytokine
Leukocyte Mediated Immunity
T Cell Selection
Adaptive Immune Response
'de Novo' Posttranslational Protein Folding
'de Novo' Protein Folding
Cellular Protein Complex Assembly
Chaperone-mediated Protein Folding
T Cell Costimulation
T Cell Differentiation In Thymus
Protein Complex Assembly
Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Macrophage Migration Inhibitory Factor Signaling Pathway
Positive Regulation Of T Cell Differentiation
Cytokine-mediated Signaling Pathway
Positive Regulation Of Lymphocyte Differentiation
Negative Regulation Of T Cell Activation
Negative Regulation Of Leukocyte Cell-cell Adhesion
T Cell Receptor Signaling Pathway
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Tagcloud (Intersection)
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