HLA-DRB5

Description		major histocompatibility complex, class II, DR beta 5
Image
GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Endosome Membrane ER To Golgi Transport Vesicle Membrane Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Late Endosome Membrane Trans-Golgi Network Membrane MHC Class II Protein Complex Extracellular Exosome Lumenal Side Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding MHC Class II Protein Complex Binding Peptide Antigen Binding
	Biological Process	Adaptive Immune Response Immune System Process Peptide Antigen Assembly With MHC Class II Protein Complex Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation
Pathways		Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules MHC class II antigen presentation Co-inhibition by PD-1 Interferon gamma signaling
Drugs		1D09C3 Coccidioides immitis spherule
Diseases
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Alzheimer's disease ( 31473137) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Antinuclear antibody levels ( 25186300) Apolipoprotein A1 levels ( 32203549) Asthma ( 27182965 31619474 30929738) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Body mass index ( 28892062) Bullous pemphigoid ( 34011352) Childhood ear infection ( 27182965) Chronic lymphocytic leukemia ( 26956414 21131588) Crohn's disease ( 23850713) Epstein Barr virus nuclear antigen 1 IgG levels ( 26819262) Frontotemporal dementia ( 24943344) Hand grip strength ( 29691431) HDL cholesterol levels ( 32203549) Heart rate response to exercise ( 29769521) High density lipoprotein cholesterol levels ( 33339817) Hip circumference adjusted for BMI ( 34021172) Hypothyroidism ( 22493691) Immune response to measles vaccine (measles-induced IFN gamma) ( 28289848) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Joint damage in rheumatoid arthritis ( 31596875) Lymphocyte count ( 32888494) Lymphoma ( 23349640) Mean spheric corpuscular volume ( 32888494) Parkinson's disease ( 27182965 21292315) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Prostate cancer ( 23535732) Refractive error ( 32231278) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Sarcoidosis (non-Lofgren's syndrome) ( 26651848) Sjögren's syndrome ( 24097066) Triglyceride levels ( 32203549) Tuberculosis ( 29036319) Type 2 diabetes ( 28869590) Ulcerative colitis ( 28067908 21297633 19122664) Vogt-Koyanagi-Harada syndrome ( 25108386) Waist-to-hip ratio adjusted for body mass index ( 26785701)
Interacting Genes		3 interacting genes: CTAG1B FXR1 HLA-DRA
Entrez ID		3127
HPRD ID		09209
Ensembl ID		ENSG00000198502
Uniprot IDs		A0A2Z4LKS3 Q30154
PDB IDs		1FV1 1H15 1HQR 1ZGL
Enriched GO Terms of Interacting Partners?		Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Cell Development Regulation Of Memory T Cell Differentiation Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class II Myeloid Dendritic Cell Antigen Processing And Presentation Positive Regulation Of Memory T Cell Differentiation T Cell Receptor Binding Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation MHC Class II Receptor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Autolysosome Membrane RNA Strand Annealing Activity Positive Regulation Of Long-term Neuronal Synaptic Plasticity Negative Regulation Of Long-term Synaptic Potentiation Nuclear Pore Localization Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of MiRNA-mediated Gene Silencing Intracellular Membraneless Organelle Nuclear Pore Complex Assembly Polysaccharide Binding Peptide Antigen Assembly With MHC Class II Protein Complex Costamere Ribonucleoprotein Granule Nuclear Pore Organization MHC Class II Protein Complex TRNA Threonylcarbamoyladenosine Metabolic Process Skeletal Muscle Organ Development Translation Regulator Activity Regulation Of Circadian Sleep/wake Cycle, Sleep Pore Complex Assembly Lumenal Side Of Endoplasmic Reticulum Membrane Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Regulatory T Cell Differentiation MHC Class II Protein Complex Binding Antigen Processing And Presentation Of Endogenous Antigen MRNA 3'-UTR AU-rich Region Binding Dentate Gyrus Development Regulation Of Circadian Sleep/wake Cycle Regulation Of Post-transcriptional Gene Silencing Regulation Of MiRNA-mediated Gene Silencing Regulation Of Long-term Neuronal Synaptic Plasticity Positive Regulation Of Rho Protein Signal Transduction Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Cytoplasmic Translational Initiation Positive Regulation Of T Cell Mediated Cytotoxicity Peptide Antigen Binding Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Development Regulation Of Regulatory T Cell Differentiation
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