H2AC8 and NAP1L4

Number of citations of the paper that reports this interaction (PubMedID 9325046)
0

Data Source:
HPRD (in vitro)

		H2AC8	NAP1L4
Description		H2A clustered histone 8	nucleosome assembly protein 1 like 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleosome Nucleus Chromosome CENP-A Containing Nucleosome Extracellular Exosome	Chromatin Nucleus Cytoplasm Dendrite Neuronal Cell Body
	Molecular Function	DNA Binding Protein Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity	Chromatin Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding Unfolded Protein Binding
	Biological Process	Chromatin Organization Negative Regulation Of Cell Population Proliferation Heterochromatin Formation Protein Localization To CENP-A Containing Chromatin	Nucleosome Assembly
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 UCH proteinases Ub-specific processing proteases Metalloprotease DUBs Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS			Aspartate aminotransferase levels ( 33547301) Calcium levels ( 20705733) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Malaria ( 31844061) Monocyte count ( 32888494) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: EID1 EP300 H2BC15 KAT8 NAP1L4	16 interacting genes: BDKRB1 CSNK2A1 CSNK2A2 EP300 ESR1 H1-1 H2AC20 H2AC8 H2BC21 H3-4 H3C14 H4C14 LINC01554 MTNR1A OGT UBC
Entrez ID		3012	4676
HPRD ID		04152	11873
Ensembl ID		ENSG00000277075	ENSG00000205531
Uniprot IDs		P04908 Q08AJ9	Q99733
PDB IDs		2CV5 2RVQ 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3W96 3W97 3W98 3W99 3WKJ 3WTP 3X1S 3X1V 4YM5 4YM6 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B40 5CPI 5CPJ 5CPK 5GSE 5GTC 5GXQ 5JRG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5Z23 5ZBX 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACL 6AEE 6BUZ 6E0C 6E0P 6HKT 6HTS 6INQ 6IPU 6IQ4 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JR0 6JR1 6JXD 6KE9 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6O1D 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6USJ 6V2K 6V92 6YOV 7BWD 7BXT 7BY0 7C0M 7CCQ 7CCR 7COW 7D1Z 7D20 7DBP 7K5X 7K5Y 7K60 7K61 7K63 7LYA 7LYB 7LYC 7NL0 7PET 7PEU 7PEV 7PEW 7PEX 7PEY 7PEZ 7PF0 7PF2 7PF3 7PF4 7PF5 7PF6 7PFA 7PFC 7PFD 7PFE 7PFF 7PFT 7PFU 7PFV 7PFW 7PFX 7SCY 7SCZ 7V90 7V96 7V99 7V9C 7V9J 7V9K 7V9S 7VA4 7VCL 7VZ4 7W9V 7WBV 7WBW 7WBX 7XCR 7XCT 7XD0 7XD1 7XSE 7XSX 7XSZ 7XT7 7XTD 7XTI 7XVL 7XVM 7XX5 7XX6 7XZX 7XZY 7XZZ 7Y00 7Y7I 7ZI4 8G57 8GRM 8H0V 8H0W 8HAG 8HAH 8HAI 8HAJ 8HAK 8HAL 8HAM 8HAN 8HE5 8HQY 8HR1 8I17 8IEG 8IEJ 8IHL 8JBX 8JCC 8JCD 8JH2 8JH3 8JH4 8JHG 8JL9 8JLA 8JLB 8JLD 8JND 8JNE 8JNF 8KB5 8KCY 8KD1 8KE0 8OSJ 8OSK 8OSL 8OTS 8OTT 8Q36 8Q3E 8Q3M 8Q3X 8RGM 8SMW 8SMX 8SMY 8SMZ 8SN0 8SN1 8SN2 8SN3 8SN4 8SN5 8SN6 8SN7 8SN8 8SN9 8SNA 8TXV 8TXW 8TXX 8U13 8U14 8UPF 8UQ8 8UQ9 8UQA 8UQB 8UQC 8UQD 8UQE 8VFX 8VFY 8VFZ 8VG0 8VG1 8VG2 8VLR 8W9D 8W9E 8W9F 8WG5 8X7I 8XBT 8XBU 8Y3C 8Y3D 8Y3E 8Y3F 8YBJ 8YBK 8YNY 8YTI 8YV8 9IPU 9J0N 9J0O 9J0P 9J8M 9J8N 9J8O
Enriched GO Terms of Interacting Partners?		Protein Propionyltransferase Activity Histone H4 Acetyltransferase Activity Chromatin Remodeling Acetyltransferase Activity Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Chromatin Organization Histone Acetyltransferase Activity Transcription Initiation-coupled Chromatin Remodeling Positive Regulation Of Gene Expression, Epigenetic Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Histone H2B Acetyltransferase Activity Chromosome Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Nucleosome Assembly Nucleosome Organization Positive Regulation Of Skeletal Muscle Satellite Cell Differentiation Acyltransferase Activity N-terminal Peptidyl-lysine Acetylation Histone H3K18 Acetyltransferase Activity Thigmotaxis Peptide Lactyltransferase (CoA-dependent) Activity Hemopoiesis DNA-binding Transcription Factor Binding Negative Regulation Of Protein Oligomerization RNA Polymerase II-specific DNA-binding Transcription Factor Binding Protein-DNA Complex Assembly MSL Complex Post-embryonic Hemopoiesis Cellular Component Assembly L-lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Positive Regulation Of TORC2 Signaling Positive Regulation Of T-helper 17 Cell Lineage Commitment Regulation Of Tubulin Deacetylation Histone H3 Acetyltransferase Activity Internal Peptidyl-lysine Acetylation Myeloid Cell Differentiation Skeletal Muscle Satellite Cell Differentiation Histone H4K16 Acetyltransferase Activity	Structural Constituent Of Chromatin Nucleosome Chromatin Organization Chromatin Remodeling Protein-DNA Complex Assembly Protein Localization To Chromosome Nucleosome Assembly Chromosome Nucleosome Organization Protein Localization To Chromatin Protein Heterodimerization Activity Protein Kinase CK2 Complex Rhythmic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Organelle Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process DNA Binding Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Chromatin DNA Binding Protein-containing Complex Assembly Cellular Component Assembly Nucleoplasm CENP-A Containing Nucleosome Protein Localization To CENP-A Containing Chromatin Protein-containing Complex Organization Negative Regulation Of Macromolecule Metabolic Process Sin3-type Complex Negative Regulation Of Protein Catabolic Process Histone Acetyltransferase Complex Circadian Rhythm Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process PcG Protein Complex Negative Regulation Of Metabolic Process Negative Regulation Of Proteolysis Negative Regulation Of Catabolic Process Nucleus Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Localization To Chromosome, Centromeric Region Transcription Coregulator Binding Negative Regulation Of Translational Initiation Regulation Of Proteasomal Protein Catabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity
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