GZMH and SSB

Number of citations: 0 (PubMedID 19039329)
Data Source: BioGRID (enzymatic study)

		GZMH	SSB
Name		granzyme H	small RNA binding exonuclease protection factor La
Structure
GO Annotations	Cellular Component	Extracellular Space Lysosome Membrane Cytolytic Granule	Chromosome, Telomeric Region Nucleus Cytoplasm Cytosol Cytoplasmic Stress Granule Ribonucleoprotein Complex
	Molecular Function	Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity	TRNA Binding Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding Poly(U) RNA Binding Sequence-specific MRNA Binding
	Biological Process	Proteolysis Apoptotic Process Killing Of Cells Of Another Organism Protein Maturation	TRNA 5'-leader Removal RNA Processing TRNA Modification TRNA Export From Nucleus TRNA Processing Histone MRNA Metabolic Process TRNA 3'-end Processing Positive Regulation Of Translation Nuclear Histone MRNA Catabolic Process IRES-dependent Viral Translational Initiation Protein Localization To Cytoplasmic Stress Granule
Pathways		Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)	RNA Polymerase III Transcription Termination RNA Polymerase III Abortive And Retractive Initiation
GWAS		No GWAS studies recorded	Common carotid intima-media thickness in HIV infection ( 29206233 ) Fasting glucose change (long-term) ( 31263163 ) Glomerular filtration rate in diabetes ( 29703844 )
Novel Interactors		None recorded	1 novel interactors: NAT8
Interacting Genes		1 interacting genes: SSB	14 interacting genes: APP CDC42 CEBPA CSNK2A1 CSNK2B GZMH H19 HMGA1 IL7R NCL OGT PTEN SPIB SPP1
Entrez ID		2999	6741
HPRD ID		00290	00168
Ensembl ID		ENSG00000100450	ENSG00000138385
Uniprot IDs		P20718	P05455
PDB IDs		3TJU 3TJV 3TK9 4GAW	1OWX 1S79 1S7A 1YTY 1ZH5 2VOD 2VON 2VOO 2VOP
GO Terms Enriched among Interactors		Nuclear Histone MRNA Catabolic Process TRNA Export From Nucleus Histone MRNA Catabolic Process TRNA Transport Protein Localization To Cytoplasmic Stress Granule IRES-dependent Viral Translational Initiation TRNA 5'-leader Removal TRNA 3'-end Processing TRNA 5'-end Processing Sequence-specific MRNA Binding Poly(U) RNA Binding Histone MRNA Metabolic Process RNA Export From Nucleus TRNA Binding RNA 3'-end Processing TRNA Modification Cytoplasmic Stress Granule Nuclear-transcribed MRNA Catabolic Process TRNA Processing Nuclear Export Viral Process RNA Modification MRNA Catabolic Process Positive Regulation Of Translation RNA Transport Chromosome, Telomeric Region TRNA Metabolic Process RNA Catabolic Process Nucleobase-containing Compound Transport Nuclear Transport Nucleocytoplasmic Transport MRNA Binding	Regulation Of Proteolysis Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Positive Regulation Of Macromolecule Metabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Neuron Projection Organization Positive Regulation Of Macromolecule Biosynthetic Process Macrophage Differentiation Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Regulation Of Cell Population Proliferation Positive Regulation Of DNA-templated Transcription Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of RNA Metabolic Process Response To Cytokine Response To Peptide Positive Regulation Of Nucleobase-containing Compound Metabolic Process Dendritic Spine Morphogenesis PML Body Negative Regulation Of Protein Metabolic Process Regulation Of Growth Regulation Of Protein Metabolic Process Mononuclear Cell Differentiation Negative Regulation Of Protein Catabolic Process Sin3-type Complex Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Molecular Function Activator Activity Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Proteolysis Leukocyte Differentiation Myeloid Leukocyte Differentiation Response To Nutrient PcG Protein Complex Regulation Of Gene Expression Negative Regulation Of Cell Population Proliferation Amyloid Fibril Formation Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Excitatory Postsynaptic Potential