SLC2A8 and AP2A2

Number of citations of the paper that reports this interaction (PubMedID 16723738)
0

Data Source:
BioGRID (pull down)

		SLC2A8	AP2A2
Description		solute carrier family 2 member 8	adaptor related protein complex 2 subunit alpha 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle	Cytosol Plasma Membrane Clathrin-coated Pit Cytoplasmic Side Of Plasma Membrane Membrane Membrane Coat AP-2 Adaptor Complex Clathrin Adaptor Complex Endocytic Vesicle Membrane Secretory Granule Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Presynapse Postsynapse Ficolin-1-rich Granule Membrane
	Molecular Function	Fructose Transmembrane Transporter Activity D-glucose Binding Transmembrane Transporter Activity Dehydroascorbic Acid Transmembrane Transporter Activity D-glucose Transmembrane Transporter Activity	Protein Binding Lipid Binding Kinase Binding Protein Kinase Binding Protein Domain Specific Binding Clathrin Adaptor Activity Disordered Domain Specific Binding
	Biological Process	Response To Hypoxia Carbohydrate Metabolic Process Male Meiosis I Insulin Receptor Signaling Pathway Hexose Transmembrane Transport Fructose Transmembrane Transport Transmembrane Transport Dehydroascorbic Acid Transport D-glucose Transmembrane Transport	Intracellular Protein Transport Endocytosis Protein Transport Vesicle-mediated Transport Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Postsynaptic Neurotransmitter Receptor Internalization
Pathways		Cellular hexose transport Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Neutrophil degranulation Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Major depressive disorder ( 27777418) Metabolite levels (HVA) ( 23319000)	Adult asthma ( 27611488) Alzheimer's disease ( 30636644) Alzheimer's disease (late onset) ( 24162737) Asthma ( 31959851) Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909) Nicotine withdrawal ( 29532581) Nicotine withdrawal symptom count ( 29532581)
Interacting Genes		4 interacting genes: AP1B1 AP2A2 AP2B1 BDKRB2	18 interacting genes: AMPH ANXA1 AP1S1 AP2B1 APP BIN1 DNAJC6 DNM1 EPN1 EPS15 HTT NLGN3 NUMB SHC1 SLC2A8 SMAD1 SNAP91 UBC
Entrez ID		29988	161
HPRD ID		05580	06256
Ensembl ID		ENSG00000136856	ENSG00000183020
Uniprot IDs		A0A087WT42 Q5VVV9 Q8WZ05 Q9NY64	O94973
PDB IDs
Enriched GO Terms of Interacting Partners?		Clathrin Adaptor Complex Membrane Coat Postsynaptic Neurotransmitter Receptor Internalization AP-2 Adaptor Complex Clathrin Adaptor Activity Endolysosome Membrane Clathrin-coated Endocytic Vesicle Clathrin-dependent Endocytosis Clathrin Binding Synaptic Vesicle Endocytosis Presynaptic Endocytosis Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Clathrin-coated Pit Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Secretion Endocytic Vesicle Membrane Intracellular Protein Transport Vesicle-mediated Transport In Synapse Cytoplasmic Side Of Plasma Membrane Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Synaptic Vesicle Cytoplasmic Vesicle Bradykinin Receptor Activity Kidney Development Receptor-mediated Endocytosis Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Protein Transport Signal Sequence Binding Vesicle-mediated Transport Basolateral Protein Secretion Extrinsic Component Of Presynaptic Endocytic Zone Membrane Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Type 1 Angiotensin Receptor Binding Intracellular Transport Endomembrane System Clathrin Coat Heart Development Establishment Of Protein Localization Postsynaptic Endocytic Zone Cellular Localization Establishment Of Localization In Cell Lysosomal Membrane AP-1 Adaptor Complex Secretion By Cell Regulation Of Cellular Response To Osmotic Stress Regulation Of Response To Osmotic Stress Endocytosis	Clathrin-coated Pit Endocytosis Import Into Cell Vesicle-mediated Transport Clathrin Binding Receptor-mediated Endocytosis Phospholipid Binding Clathrin Coat Assembly Extrinsic Component Of Presynaptic Endocytic Zone Membrane Cytoplasmic Vesicle Vesicle-mediated Transport In Synapse Synaptic Vesicle Endocytosis Presynaptic Endocytosis Synaptic Vesicle Regulation Of Endocytosis Early Endosome Clathrin-coated Vesicle Regulation Of Vesicle-mediated Transport Establishment Of Localization In Cell Clathrin-dependent Endocytosis Synapse Regulation Of Receptor-mediated Endocytosis Cellular Response To Growth Factor Stimulus Endosome Postsynaptic Neurotransmitter Receptor Internalization Response To Growth Factor Plasma Membrane Postsynaptic Endocytic Zone Cytoplasmic Vesicle Membrane Intracellular Transport Clathrin Heavy Chain Binding Vesicle Regulation Of Transport AP-2 Adaptor Complex Organelle Organization Presynapse Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Clathrin Adaptor Activity Regulation Of Multicellular Organismal Development Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Cellular Component Organization Cellular Localization Negative Regulation Of Blood Circulation Regulation Of Developmental Process Insulin Receptor Binding Membrane Regulation Of Cellular Component Organization Positive Regulation Of Transport Membrane Coat Chemical Synaptic Transmission
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