ALG5 and PGD

		ALG5	PGD
Description		ALG5 dolichyl-phosphate beta-glucosyltransferase	phosphogluconate dehydrogenase
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Cytoplasmic Side Of Rough Endoplasmic Reticulum Membrane	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Dolichyl-phosphate Beta-glucosyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity	Phosphogluconate Dehydrogenase (decarboxylating) Activity Oxidoreductase Activity Carbohydrate Binding Carboxylic Acid Binding NADP Binding
	Biological Process	Protein Glycosylation Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Determination Of Left/right Symmetry Protein N-linked Glycosylation Via Asparagine	Pentose-phosphate Shunt NADP+ Metabolic Process NADPH Regeneration Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process D-gluconate Metabolic Process
Pathways		Synthesis of dolichyl-phosphate-glucose	Pentose phosphate pathway NFE2L2 regulates pentose phosphate pathway genes
Drugs			Gadopentetic acid Dacarbazine Ketotifen 6-phospho-D-gluconic acid Nicotinamide 8-bromo-adenine dinucleotide phosphate
Diseases
GWAS		Interleukin-10 levels ( 22205395)	Hemoglobin ( 32888494) Hepatocellular carcinoma ( 20676096) Metabolite levels ( 23823483)
Interacting Genes			8 interacting genes: CDC42 CDK4 GBE1 LINC00632 LINC01554 LSM8 OGT TERF1
Entrez ID		29880	5226
HPRD ID		05193	01391
Ensembl ID		ENSG00000120697	ENSG00000142657
Uniprot IDs		Q9Y673	B4E2U0 P52209
PDB IDs			2JKV 4GWG 4GWK 5UQ9
Enriched GO Terms of Interacting Partners?		Carbohydrate Binding Pentose-phosphate Shunt, Oxidative Branch Pentose Biosynthetic Process D-gluconate Metabolic Process Phosphogluconate Dehydrogenase (decarboxylating) Activity Cellular Response To Vitamin K Bone Regeneration Oocyte Differentiation Response To Vitamin K Pentose Metabolic Process Carboxylic Acid Binding Regulation Of Opsonization Serine-type Endopeptidase Complex Positive Regulation Of Opsonization Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Complement Activation, Lectin Pathway Pentose-phosphate Shunt Negative Regulation Of Substrate Adhesion-dependent Cell Spreading	Glycosyltransferase Activity 1,4-alpha-glucan Branching Enzyme Activity Negative Regulation Of Establishment Of Protein Localization To Telomere Negative Regulation Of Establishment Of Protein-containing Complex Localization To Telomere Negative Regulation Of Establishment Of RNA Localization To Telomere Positive Regulation Of Shelterin Complex Assembly Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Glycosylation-dependent Protein Binding Dolichyl-phosphate Beta-glucosyltransferase Activity GBD Domain Binding Storage Vacuole Cyclin D1-CDK4 Complex Cyclin D3-CDK4 Complex Negative Regulation Of Telomeric D-loop Disassembly Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication
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