GRHL1 and GRHL3

Number of citations of the paper that reports this interaction (PubMedID 12549979)
30

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid)

		GRHL1	GRHL3
Description		grainyhead like transcription factor 1	grainyhead like transcription factor 3
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytosol Cilium Actin Cytoskeleton
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding
	Biological Process	Desmosome Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Epidermis Development Regulation Of Keratinocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Skin Barrier	Establishment Of Planar Polarity Neural Tube Closure Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Pattern Specification Process Ectoderm Development Central Nervous System Development Epidermis Development Gene Expression Positive Regulation Of Gene Expression Regulation Of Actin Cytoskeleton Organization Wound Healing Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Eyelid Development In Camera-type Eye Establishment Of Skin Barrier Cochlea Morphogenesis
Pathways		PPARA activates gene expression
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Breast cancer ( 29059683) Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Prostate cancer ( 23535732) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408)	Cleft palate ( 27018472) Fasting blood insulin (BMI interaction) ( 22581228) Male-pattern baldness ( 28196072) Response to interferon beta in multiple sclerosis ( 26644207)
Interacting Genes		1 interacting genes: GRHL3	8 interacting genes: EAF1 ENKD1 GRHL1 GRHL2 PRMT1 PRMT5 PRMT6 RIPPLY1
Entrez ID		29841	57822
HPRD ID		18176	12210
Ensembl ID		ENSG00000134317	ENSG00000158055
Uniprot IDs		Q9NZI5	Q8TE85
PDB IDs		5MPF 5MPH 5MPI
Enriched GO Terms of Interacting Partners?		Establishment Of Planar Polarity Eyelid Development In Camera-type Eye Ectoderm Development Cochlea Morphogenesis Skin Epidermis Development Establishment Of Skin Barrier Tube Closure Chromatin DNA Binding Wound Healing Neural Tube Closure	Histone H4R3 Methyltransferase Activity Protein-arginine N-methyltransferase Activity Histone Methyltransferase Activity Histone Arginine N-methyltransferase Activity Protein-arginine Omega-N Monomethyltransferase Activity Peptidyl-arginine Methylation Protein-arginine Omega-N Asymmetric Methyltransferase Activity Methylosome Regulation Of DNA-templated Transcription Methyltransferase Activity Regulation Of RNA Biosynthetic Process Histone H3 Methyltransferase Activity Methyl-CpG Binding Regulation Of RNA Metabolic Process Methylation Protein Methylation Regulation Of Megakaryocyte Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process GATOR1 Complex Binding Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Histone H2AR3 Methyltransferase Activity Epithelium Migration Regulation Of Gene Expression Chromatin DNA Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Peptidyl-arginine N-methylation Histone H3R2 Methyltransferase Activity Macromolecule Methylation Protein-arginine Omega-N Symmetric Methyltransferase Activity Regulation Of Signal Transduction By P53 Class Mediator Epithelial Cell Morphogenesis Involved In Placental Branching Intronic Transcription Regulatory Region Sequence-specific DNA Binding N-methyltransferase Activity Regulation Of Macromolecule Metabolic Process Epidermis Development Anterior Neural Tube Closure Positive Regulation Of Hemoglobin Biosynthetic Process Positive Regulation Of Dopamine Receptor Signaling Pathway Somite Specification Regulation Of Multicellular Organismal Development Nucleoplasm Chromatin Remodeling Cellular Response To Methionine Super Elongation Complex Cell-cell Junction Organization Regulation Of Hemoglobin Biosynthetic Process Mitogen-activated Protein Kinase P38 Binding Response To Methionine Histone H4 Methyltransferase Activity
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