GRHL1 and GRHL3

Number of citations of the paper that reports this interaction (PMID 12549979)
16

Data Source:
BioGRID (pull down)
HPRD (two hybrid, in vitro)

		GRHL1	GRHL3
Gene Name		grainyhead-like 1 (Drosophila)	grainyhead-like 3 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Intracellular Membrane-bounded Organelle	Nucleus
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Sequence-specific DNA Binding	Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Multicellular Organismal Development Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter	Establishment Of Planar Polarity Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Pattern Specification Process Ectoderm Development Central Nervous System Development Epidermis Development Positive Regulation Of Rho GTPase Activity Regulation Of Actin Cytoskeleton Organization Wound Healing Positive Regulation Of Transcription From RNA Polymerase II Promoter Eyelid Development In Camera-type Eye Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Fasting insulin-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		1 interactors: GRHL3	5 interactors: GRHL1 GRHL2 PRMT1 PRMT5 PRMT6
Entrez ID		29841	57822
HPRD ID		18176	12210
Ensembl ID		ENSG00000134317	ENSG00000158055
Uniprot IDs		Q9NZI5	Q8TE85
PDB IDs
Enriched GO Terms of Interacting Partners?		Planar Cell Polarity Pathway Involved In Neural Tube Closure Regulation Of Establishment Of Planar Polarity Involved In Neural Tube Closure Eyelid Development In Camera-type Eye Establishment Of Planar Polarity Wnt Signaling Pathway, Planar Cell Polarity Pathway Morphogenesis Of A Polarized Epithelium Ectoderm Development Cochlea Morphogenesis Non-canonical Wnt Signaling Pathway Cochlea Development Inner Ear Morphogenesis Regulation Of Embryonic Development Ear Morphogenesis	Histone H4-R3 Methylation Peptidyl-arginine N-methylation Histone Arginine Methylation Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Asymmetrical-dimethyl Arginine Histone Methylation Protein Methylation Histone Modification Methylation Chromatin Modification Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Chromatin Organization Regulation Of Gene Expression Histone H3-R2 Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Regulation Of Nitrogen Compound Metabolic Process Transcription, DNA-templated RNA Biosynthetic Process Peptidyl-amino Acid Modification Chromosome Organization Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Telomerase Activity RNA Metabolic Process Negative Regulation Of Hematopoietic Progenitor Cell Differentiation Gene Expression Cellular Macromolecule Biosynthetic Process Lung Lobe Morphogenesis Macromolecule Biosynthetic Process Endothelial Cell Activation Regulation Of Telomerase Activity Regulation Of Metabolic Process Regulation Of Megakaryocyte Differentiation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of DNA Biosynthetic Process In Utero Embryonic Development Regulation Of DNA Methylation Nucleobase-containing Compound Metabolic Process Regulation Of Hematopoietic Progenitor Cell Differentiation Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cell Proliferation Spliceosomal SnRNP Assembly Regulation Of DNA Biosynthetic Process Chordate Embryonic Development Tight Junction Assembly
Tagcloud ?		aire amp creb1 drive erg forkhead foxm1 foxp3 get glis2 grainyhead hnf1a hnf4a hub hubs interconnected m1 pu quantitatively spi1 stimulatory tcf tp53l tp63 transactivator trop trop2 web wilms	ad advanced augmented chosen circulating clusterin differentially displayed division ed employing enrolling gelsolin htert investigation lumican mismatch plasmatic pms2 presented profile proteomic proteomics repair sall4 stages throughput tnf tumors
Tagcloud (Difference) ?		aire amp creb1 drive erg forkhead foxm1 foxp3 get glis2 grainyhead hnf1a hnf4a hub hubs interconnected m1 pu quantitatively spi1 stimulatory tcf tp53l tp63 transactivator trop trop2 web wilms	ad advanced augmented chosen circulating clusterin differentially displayed division ed employing enrolling gelsolin htert investigation lumican mismatch plasmatic pms2 presented profile proteomic proteomics repair sall4 stages throughput tnf tumors
Tagcloud (Intersection) ?