RANGRF and RANBP1

Number of citations: 0 (PubMedID 10811801)
Data Source: HPRD (in vitro)

		RANGRF	RANBP1
Name		RAN guanine nucleotide release factor	RAN binding protein 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Rough Endoplasmic Reticulum Cytosol Plasma Membrane Caveola Intercalated Disc Membrane Perinuclear Region Of Cytoplasm	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Centrosome Cytosol
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Sodium Channel Regulator Activity Small GTPase Binding Transmembrane Transporter Binding Channel Activator Activity	GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Cadherin Binding
	Biological Process	Regulation Of Heart Rate Regulation Of Membrane Depolarization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Protein Transport Protein Exit From Endoplasmic Reticulum Heart Contraction Mitotic Spindle Assembly Regulation Of Bundle Of His Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Cell Surface	Nucleocytoplasmic Transport Signal Transduction Positive Regulation Of Mitotic Centrosome Separation
Pathways		Phase 0 - rapid depolarisation	Rev-mediated nuclear export of HIV RNA
Drugs		None	Copper Phenethyl Isothiocyanate
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		None recorded	1 novel interactors: PRODH
Interacting Genes		4 interacting genes: PTPN11 RAN RANBP1 ZDHHC17	7 interacting genes: CD93 CEBPA MDM2 NUPR1 RAN RANGRF RCC1
Entrez ID		29098	5902
HPRD ID		06407	03110
Ensembl ID		ENSG00000108961	ENSG00000099901
Uniprot IDs		Q9HD47	A0A140VK94 B3KUP2 B4DE76 F6WQW2 P43487
PDB IDs		5YFG	1K5D 1K5G
GO Terms Enriched among Interactors		Cadherin Binding Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Regulation Of Intracellular Protein Transport Regulation Of Nucleocytoplasmic Transport Intestinal Epithelial Cell Migration Axonogenesis RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Nuclear Pore Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Cerebellar Cortex Formation Positive Regulation Of Mitotic Centrosome Separation Cell Projection Morphogenesis Negative Regulation Of Neutrophil Activation Regulation Of ERK1 And ERK2 Cascade Neuron Projection Morphogenesis Negative Regulation Of Glucocorticoid Secretion Regulation Of Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Nuclear Envelope RNA Import Into Nucleus Regulation Of Mitotic Centrosome Separation Protein-cysteine S-myristoyltransferase Activity Protein-cysteine S-stearoyltransferase Activity Microvillus Organization Non-membrane Spanning Protein Tyrosine Phosphatase Activity Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Atrioventricular Canal Development Regulation Of Neutrophil Activation Peptide Hormone Receptor Binding Negative Regulation Of Cell Adhesion Mediated By Integrin Bergmann Glial Cell Differentiation Positive Regulation Of Cell Cycle Neutrophil Activation Involved In Immune Response Cellular Response To Mineralocorticoid Stimulus Nuclear Export Signal Receptor Activity Protein Localization To Nucleolus Pre-miRNA Binding Importin-alpha Family Protein Binding Ribosomal Subunit Export From Nucleus Regulation Of Neurotrophin TRK Receptor Signaling Pathway Regulation Of Growth Hormone Secretion Golgi-associated Vesicle Membrane	Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Spindle Organization Chromatin Binding Spindle Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Domain Specific Binding Nucleoplasm Protein-containing Complex Acute Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Heterodimerization Activity Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Protein Catabolic Process Response To Vitamin Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Response To Vitamin B2 Regulation Of Cell Cycle C/EBP Complex Microtubule Cytoskeleton Organization Spindle Assembly Positive Regulation Of Intracellular Protein Transport Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization Signal Transduction By P53 Class Mediator Response To Toxic Substance Proline Dehydrogenase Activity RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Heart Rate Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Response To Vitamin B1 Regulation Of Cellular Localization Response To Water-immersion Restraint Stress Regulation Of Nucleocytoplasmic Transport Cellular Response To Actinomycin D L-proline Catabolic Process To L-glutamate Negative Regulation Of Type B Pancreatic Cell Proliferation