B3GNT2 and TMEM246

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		B3GNT2	TMEM246
Gene Name		UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	transmembrane protein 246
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Integral Component Of Membrane Extracellular Vesicular Exosome	Integral Component Of Membrane
	Molecular Function	Galactosyltransferase Activity N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity
	Biological Process	Carbohydrate Metabolic Process Protein O-linked Glycosylation Axon Guidance Sensory Perception Of Smell Biological_process Pathogenesis O-glycan Processing Keratan Sulfate Biosynthetic Process Glycosaminoglycan Metabolic Process Poly-N-acetyllactosamine Biosynthetic Process Keratan Sulfate Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		MPS IIIB - Sanfilippo syndrome B Diseases of glycosylation Defective B4GALT7 causes EDS, progeroid type MPS I - Hurler syndrome Keratan sulfate/keratin metabolism MPS IX - Natowicz syndrome Defective SLC26A2 causes chondrodysplasias Glycosaminoglycan metabolism O-linked glycosylation Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) Defective CHST14 causes EDS, musculocontractural type Defective PAPSS2 causes SEMD-PA MPS IIIA - Sanfilippo syndrome A Myoclonic epilepsy of Lafora Glycogen storage diseases Defective CHST6 causes MCDC1 MPS IIID - Sanfilippo syndrome D MPS IIIC - Sanfilippo syndrome C Keratan sulfate biosynthesis Diseases associated with glycosaminoglycan metabolism Mucopolysaccharidoses Post-translational protein modification Defective EXT2 causes exostoses 2 MPS II - Hunter syndrome Defective B3GAT3 causes JDSSDHD Defective CHST3 causes SEDCJD Defective EXT1 causes exostoses 1, TRPS2 and CHDS MPS IV - Morquio syndrome A MPS IV - Morquio syndrome B Defective CHSY1 causes TPBS Metabolism of carbohydrates MPS VII - Sly syndrome O-linked glycosylation of mucins MPS VI - Maroteaux-Lamy syndrome
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 20062062) Rheumatoid arthritis ( 22446963)
Protein-Protein Interactions		2 interactors: C1GALT1C1 TMEM246	1 interactors: B3GNT2
Entrez ID		10678	84302
HPRD ID		09279	12940
Ensembl ID		ENSG00000170340
Uniprot IDs		Q9NY97	Q9BRR3
PDB IDs
Enriched GO Terms of Interacting Partners?		Platelet Morphogenesis	Poly-N-acetyllactosamine Biosynthetic Process Poly-N-acetyllactosamine Metabolic Process Keratan Sulfate Biosynthetic Process Keratan Sulfate Metabolic Process Cellular Polysaccharide Biosynthetic Process Polysaccharide Biosynthetic Process O-glycan Processing Polysaccharide Metabolic Process Protein O-linked Glycosylation Glycosaminoglycan Biosynthetic Process Carbohydrate Biosynthetic Process Glycosaminoglycan Metabolic Process Post-translational Protein Modification Pathogenesis Cellular Carbohydrate Metabolic Process Macromolecule Glycosylation Protein Glycosylation Glycosylation Sulfur Compound Metabolic Process Sensory Perception Of Smell Axon Guidance Glycoprotein Biosynthetic Process
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