B3GNT2 and C1GALT1C1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		B3GNT2	C1GALT1C1
Description		UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	C1GALT1 specific chaperone 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Membrane	Golgi Membrane Membrane Extracellular Exosome
	Molecular Function	Protein Binding N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Transferase Activity Glycosyltransferase Activity Hexosyltransferase Activity	Protein Binding Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity
	Biological Process	Protein Glycosylation Protein O-linked Glycosylation Axon Guidance Sensory Perception Of Smell Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Poly-N-acetyllactosamine Biosynthetic Process Cellular Response To Leukemia Inhibitory Factor	Protein O-linked Glycosylation Platelet Activation Platelet Morphogenesis
Pathways		Keratan sulfate biosynthesis O-linked glycosylation of mucins	Defective C1GALT1C1 causes TNPS O-linked glycosylation of mucins
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 20062062) Blood protein levels ( 30072576) Coronary artery disease in type 1 diabetes ( 32077919) Iron status biomarkers (total iron binding capacity) ( 28334935) Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 29403010) Psoriasis ( 23143594 25903422) Psoriasis vulgaris ( 26626624) Rheumatoid arthritis ( 22446963 24390342 30423114)	Serum galactose-deficient IgA1 levels ( 28187132)
Interacting Genes		2 interacting genes: C1GALT1C1 PGAP4	3 interacting genes: B3GNT2 C1GALT1 LGALS3
Entrez ID		10678	29071
HPRD ID		09279	06462
Ensembl ID		ENSG00000170340	ENSG00000171155
Uniprot IDs		Q9NY97	Q96EU7
PDB IDs		6WMM 6WMN 6WMO 7JHK 7JHL 7JHM 7JHN 7JHO 8SZ3 8TIC 8TJC
Enriched GO Terms of Interacting Partners?		Cell Morphogenesis Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Regulation Of Embryonic Cell Shape Axonemal Basal Plate Platelet Morphogenesis Septin Cytoskeleton Organization Tongue Morphogenesis Auditory Receptor Cell Morphogenesis Podocyte Cell Migration Respiratory System Development Digestive System Development Carbohydrate Derivative Biosynthetic Process Golgi Membrane Establishment Of Planar Polarity Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Establishment Of Cell Polarity Circulatory System Development Regulation Of Establishment Or Maintenance Of Cell Polarity GPI Anchor Metabolic Process GPI Anchor Biosynthetic Process Regulation Of Ruffle Assembly Carbohydrate Derivative Metabolic Process Epithelial Cell Migration Regulation Of Fibroblast Migration Neural Tube Development Intraciliary Transport	Disaccharide Binding Negative Regulation Of Immunological Synapse Formation Protein O-linked Glycosylation Protein Glycosylation Glycosyltransferase Activity Glycosylation Macromolecule Glycosylation Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase Activity Glycoprotein Biosynthetic Process Negative Regulation Of NK T Cell Activation Negative Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Glycoprotein Metabolic Process Positive Regulation Of Dendritic Cell Differentiation Receptor Ligand Inhibitor Activity IgE Binding N-acetyllactosaminide Beta-1,3-N-acetylglucosaminyltransferase Activity Poly-N-acetyllactosamine Biosynthetic Process Poly-N-acetyllactosamine Metabolic Process Signaling Receptor Inhibitor Activity NK T Cell Activation N-acetyl-beta-D-glucosaminide Beta-(1,3)-galactosyltransferase Activity Intestinal Epithelial Cell Development Carbohydrate Derivative Biosynthetic Process Oligosaccharide Binding Keratan Sulfate Proteoglycan Biosynthetic Process Regulation Of Dendritic Cell Differentiation Keratan Sulfate Proteoglycan Metabolic Process Columnar/cuboidal Epithelial Cell Development Macrophage Chemotaxis Laminin Binding Macrophage Migration Monocyte Chemotaxis Eosinophil Migration Eosinophil Chemotaxis Golgi Membrane Hexosyltransferase Activity Positive Regulation Of Calcium Ion Import Negative Regulation Of T Cell Receptor Signaling Pathway Chemoattractant Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Carbohydrate Derivative Metabolic Process Regulation Of T Cell Apoptotic Process Immunological Synapse Positive Chemotaxis Regulation Of Calcium Ion Import Protein Phosphatase Inhibitor Activity Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Molecular Condensate Scaffold Activity Negative Regulation Of Alpha-beta T Cell Activation Regulation Of T Cell Receptor Signaling Pathway
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