TMEM14A and SLC18A1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TMEM14A	SLC18A1
Description		transmembrane protein 14A	solute carrier family 18 member A1
Image
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Mitochondrial Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Transport Vesicle Membrane Secretory Granule Membrane Synaptic Vesicle Membrane Cytoplasmic Vesicle Terminal Bouton Synapse Clathrin-sculpted Monoamine Transport Vesicle Membrane Presynapse
	Molecular Function	Protein Binding	Serotonin:sodium:chloride Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Monoamine:proton Antiporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity
	Biological Process	Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway	Neurotransmitter Transport Serotonin Transport Aminergic Neurotransmitter Loading Into Synaptic Vesicle Monoamine Transport Dopamine Transport Xenobiotic Transport Serotonin Uptake Norepinephrine Uptake Establishment Of Localization In Cell Transmembrane Transport Dopamine Uptake Proton Transmembrane Transport
Pathways
Drugs			Reserpine Norepinephrine Ephedra sinica root MMDA Metamfetamine
Diseases
GWAS		Metabolite levels ( 23823483) Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Response to hepatitis B vaccine ( 29534301)	Apolipoprotein A1 levels ( 32203549) Cholesterol ( 31902109) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertriglyceridemia ( 23505323) Major depressive disorder (broad) ( 20038947) Metabolic syndrome ( 30382898 31589552) Persistent hepatitis B virus infection ( 27244555) Pulse pressure ( 27841878) Response to selenium supplementation (change in plasma selenium concentration) ( 33382417) Systolic blood pressure ( 27841878) Triglyceride levels ( 32203549) Triglyceride levels in HIV infection ( 33109212) Triglycerides ( 18193046 24886709)
Interacting Genes		39 interacting genes: AQP6 CLN8 CPLX4 CREB3 CREB3L1 CXCR3 ERBB3 ERBB4 ERGIC3 ERMAP FAM209A FKBP7 IER3IP1 KCNK5 LMNA LRCH1 LXN MMGT1 MTNR1A MTNR1B MUC1 NEMP1 PDZK1IP1 SAR1A SCN3B SERINC2 SLC10A6 SLC18A1 SLC19A3 SLC35H1 SLC7A1 SSMEM1 TMEM14B TMEM179B TMEM31 TMEM51 TMEM80 TMEM86B USP18	88 interacting genes: ADGRE2 AGTRAP ANKRD46 APOL2 BRICD5 BTN2A2 C1GALT1 C2CD2L CCL4 CCL4L2 CD81 CNIH1 COL4A5 CTSA CXCL16 CYB561D2 ERMP1 FAM3C FCER1G FXYD3 GIMAP1 GJB2 GPR151 HTATIP2 INSIG2 LAT MALL MARCHF2 MFSD6 MGAM MGLL MIP MS4A1 MS4A13 NEU1 NRM OLFM4 ORMDL1 PEX16 PLP1 PLP2 PMP22 PNLIPRP1 RABAC1 RPRM SCD SEC22A SELENOK SERP1 SLC30A2 SLC30A3 SLC30A8 SLC35B4 SLC35G1 SLC38A7 SLC39A2 SMCO4 SMIM1 STX2 STX7 STX8 SYNGR1 TECR TFRC TMEM120B TMEM128 TMEM147 TMEM14A TMEM14B TMEM14C TMEM203 TMEM218 TMEM239 TMEM42 TMEM60 TMEM65 TMEM86A TMEM97 TSPO2 UPK1B UPK2 VAMP5 VAPA VAPB VTI1B YIPF1 YIPF4 YIPF6
Entrez ID		28978	6570
HPRD ID		15522	01897
Ensembl ID		ENSG00000096092	ENSG00000036565
Uniprot IDs		Q9Y6G1	P54219 Q96GL6
PDB IDs		2LOO 2LOP	8TGG 8TGH 8TGI 8TGJ 8TGK 8TGL 8TGM 8TGN
Enriched GO Terms of Interacting Partners?		Membrane Negative Regulation Of Apoptotic Process Neuregulin Receptor Activity Negative Regulation Of Programmed Cell Death Melatonin Receptor Activity Transmembrane Transport	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Plasma Membrane Membrane Docking Protein Binding SNAP Receptor Activity Organelle Localization By Membrane Tethering Chloride Channel Inhibitor Activity Membrane Organization Zinc Ion Transmembrane Transporter Activity Vesicle-mediated Transport Zinc Ion Transmembrane Transport Zinc Ion Transport Membrane Fusion Zinc Ion Import Into Organelle Cellular Localization Endomembrane System FFAT Motif Binding Monoatomic Cation Transmembrane Transporter Activity SNARE Complex Zinc Ion Import Into Lysosome Vesicle Fusion Organelle Membrane Fusion Lysosome Zinc:proton Antiporter Activity COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Vesicle Docking Establishment Of Localization In Cell Vesicle SNARE Binding Intracellular Transport Fatty Acid Biosynthetic Process Gap Junction-mediated Intercellular Transport Cytoplasmic Vesicle Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Positive Regulation Of Protein Catabolic Process In The Vacuole Endoplasmic Reticulum Localization Vesicle Fusion With Golgi Apparatus Organelle Fusion Golgi Vesicle Transport Transmembrane Transport Lysosomal Membrane Vacuolar Transmembrane Transport Synaptic Vesicle Golgi Trans Cisterna Secretory Vesicle Golgi Medial Cisterna Metal Ion Transport
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