GRK4 and BDKRB2

Number of citations of the paper that reports this interaction (PubMedID 11517230)
0

Data Source:
HPRD (in vivo, in vitro)

		GRK4	BDKRB2
Description		G protein-coupled receptor kinase 4	bradykinin receptor B2
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Photoreceptor Disc Membrane	Endosome Plasma Membrane Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Rhodopsin Kinase Activity	Protease Binding Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity G Protein-coupled Receptor Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Signal Transduction Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Signal Transduction Regulation Of Opsin-mediated Signaling Pathway Receptor Internalization	System Process Smooth Muscle Contraction Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Response To Salt Stress Regulation Of Vasoconstriction Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonate Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways			Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs			Anatibant Icatibant Labradimil
Diseases
GWAS		Hip circumference adjusted for BMI ( 28552196) Household income (MTAG) ( 31844048) Mean platelet volume ( 32888494) Myocardial infarction ( 33532862) Smoking behaviour (cigarettes smoked per day) ( 30617275)	Cerebrospinal fluid AB1-42 levels ( 28247064) Corneal astigmatism ( 30306274) Gout ( 22179738) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Mumps ( 28928442) Subcutaneous adipose tissue ( 26480920)
Interacting Genes		7 interacting genes: ADRB2 BDKRB2 CALM1 FSHR IKBKG NEDD4 SNCA	33 interacting genes: AATK ACE AGTR1 AP2M1 CD81 CD82 CLCA4 EFS GNA11 GRK2 GRK3 GRK4 GRK5 GRK6 HERC2 INF2 MPI NIF3L1 NOS1 NOS3 PEX16 PRKCD PTPN11 SLC2A8 SLC35A4 SPG7 SPNS1 SYNE1 SYNGR2 TMEM11 TMEM70 TPI1 USP4
Entrez ID		2868	624
HPRD ID		00656	00213
Ensembl ID		ENSG00000125388	ENSG00000168398
Uniprot IDs		P32298	P30411
PDB IDs		4YHJ	7F2O 7F6H 7F6I
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Regulation Of Signaling Regulation Of Metal Ion Transport Positive Regulation Of Signal Transduction Regulation Of Autophagy Regulation Of Monoatomic Ion Transport Endocytosis Regulation Of Membrane Potential Positive Regulation Of Intracellular Signal Transduction Vesicle-mediated Transport Positive Regulation Of Catabolic Process Receptor-mediated Endocytosis Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Receptor Complex Regulation Of Macroautophagy Import Into Cell Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Protein Domain Specific Binding Negative Regulation Of Signal Transduction Regulation Of Systemic Arterial Blood Pressure Presynaptic Endocytosis Regulation Of Monoatomic Cation Transmembrane Transport Negative Regulation Of Cell Communication Negative Regulation Of Signaling G Protein-coupled Receptor Signaling Pathway Vasodilation Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Establishment Of Localization In Cell Long-term Synaptic Potentiation Regulation Of Monoatomic Ion Transmembrane Transport Protein-containing Complex Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Smooth Muscle Contraction Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Signal Transduction Regulation Of Sodium Ion Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Negative Regulation Of Cation Transmembrane Transport Response To Metal Ion Cell Surface Receptor Signaling Pathway Via JAK-STAT Follicle-stimulating Hormone Receptor Activity Regulation Of Acetylcholine Metabolic Process Formation Of Structure Involved In A Symbiotic Process	G Protein-coupled Receptor Kinase Activity Beta-adrenergic Receptor Kinase Activity Receptor Internalization Regulation Of G Protein-coupled Receptor Signaling Pathway Bradykinin Receptor Binding Vasodilation Protein Serine/threonine Kinase Activity Blood Vessel Diameter Maintenance Regulation Of Tube Size Nitric-oxide Synthase Activity Tetrahydrobiopterin Binding Regulation Of The Force Of Heart Contraction Regulation Of Blood Pressure Receptor-mediated Endocytosis Regulation Of Systemic Arterial Blood Pressure Mediated By A Chemical Signal Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Cadmium Ion Binding Protein Kinase Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Desensitization Of G Protein-coupled Receptor Signaling Pathway Negative Adaptation Of Signaling Pathway L-arginine Catabolic Process Regulation Of Systemic Arterial Blood Pressure Tachykinin Receptor Signaling Pathway Arginine Binding Regulation Of Blood Circulation Kinase Activity Plasma Membrane Membrane Vascular Process In Circulatory System Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin FMN Binding Circulatory System Process G Protein-coupled Receptor Binding Regulation Of Heart Contraction G Protein-coupled Receptor Signaling Pathway Regulation Of Transport Regulation Of Biological Quality Regulation Of System Process Arginine Metabolic Process Negative Regulation Of Platelet Activation Angiotensin-activated Signaling Pathway Renal System Process Involved In Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Mediated Signal Transduction G Protein-coupled Acetylcholine Receptor Signaling Pathway Metalloendopeptidase Activity Nitric Oxide Biosynthetic Process Positive Regulation Of Transport Regulation Of Cell Communication Regulation Of Signaling
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