GRK4 and BDKRB2

Number of citations of the paper that reports this interaction (PMID 11517230)
13

Data Source:
HPRD (in vitro, in vivo)

		GRK4	BDKRB2
Gene Name		G protein-coupled receptor kinase 4	bradykinin receptor B2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell Cortex Dendrite Neuronal Cell Body	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	G-protein Coupled Receptor Kinase Activity ATP Binding Rhodopsin Kinase Activity	Protease Binding Phosphatidylinositol Phospholipase C Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	G-protein Coupled Receptor Internalization Protein Phosphorylation Signal Transduction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor Internalization Termination Of G-protein Coupled Receptor Signaling Pathway	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Metabolic Process Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS
Protein-Protein Interactions		5 interactors: BDKRB2 CALM1 FSHR IKBKG NEDD4	12 interactors: ACE ADRBK1 ADRBK2 AGTR1 GNA11 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11
Entrez ID		2868	624
HPRD ID		00656	00213
Ensembl ID		ENSG00000125388	ENSG00000168398
Uniprot IDs		P32298	P30411
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Cellular Response To Light Stimulus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Ion Transport Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator Transmission Of Virus Development Involved In Symbiotic Interaction Response To Calcium Ion Regulation Of Protein Metabolic Process Cellular Response To Radiation Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Intrinsic Apoptotic Signaling Pathway Signal Transduction Intracellular Receptor Signaling Pathway Signaling Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Muscle Contraction Regulation Of Protein Phosphorylation Cell Communication Regulation Of Signal Transduction Negative Regulation Of Signal Transduction Fc-epsilon Receptor Signaling Pathway Response To Abiotic Stimulus Follicle-stimulating Hormone Signaling Pathway Regulation Of High Voltage-gated Calcium Channel Activity G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Signaling Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Progesterone Receptor Signaling Pathway Muscle System Process Fc Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Signaling Regulation Of Transcription From RNA Polymerase II Promoter In Response To UV-induced DNA Damage Immune Response Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Phosphorylation Defense Response Glucocorticoid Receptor Signaling Pathway Regulation Of Response To Osmotic Stress Cellular Response To Stimulus Negative Regulation Of Protein Phosphorylation Response To Metal Ion Response To Light Stimulus Response To Stress	Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Vasodilation Negative Regulation Of Signal Transduction Blood Circulation Regulation Of The Force Of Heart Contraction Signal Transduction Regulation Of Signal Transduction Receptor Internalization Blood Coagulation Signaling Hemostasis Regulation Of Blood Pressure Regulation Of Signaling Cell Communication Positive Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Wound Healing Arginine Catabolic Process Cellular Response To Stimulus Tachykinin Receptor Signaling Pathway Receptor Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Guanylate Cyclase Activity Response To Wounding Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Biosynthetic Process Regulation Of Blood Volume By Renin-angiotensin Protein Phosphorylation Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cell Surface Receptor Signaling Pathway Negative Regulation Of Platelet Activation Cellular Protein Metabolic Process Nitric Oxide Mediated Signal Transduction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Protein Modification Process Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of MRNA Catabolic Process Regulation Of Catalytic Activity Negative Regulation Of Potassium Ion Transport Regulation Of CGMP Biosynthetic Process
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk5 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Intersection) ?