FAM133A and MACROH2A2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM133A	MACROH2A2
Description		family with sequence similarity 133 member A	macroH2A.2 histone
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Telomeric Region Chromatin Nucleosome Barr Body Nucleus Nucleoplasm Chromosome Extracellular Exosome
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Protein Heterodimerization Activity
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Brain Development Dosage Compensation By Inactivation Of X Chromosome Heterochromatin Formation Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Establishment Of Protein Localization To Chromatin Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Pathways
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: AGPAT3 BEND7 C1orf35 CCNL1 CEP70 CT45A1 H2BC15 MACROH2A1 MACROH2A2 NKAPD1 PRR13 RBMX2 RNF151 SDCBP2 STAC3 THAP1 TRIM23	3 interacting genes: FAM133A H2BC15 WWP1
Entrez ID		286499	55506
HPRD ID		06562	13625
Ensembl ID		ENSG00000179083	ENSG00000099284
Uniprot IDs		Q8N9E0	Q9P0M6
PDB IDs			2XD7 6FY5
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Barr Body Negative Regulation Of Transcription By RNA Polymerase I Establishment Of Protein Localization To Chromatin Structural Constituent Of Chromatin Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Nucleosome Nucleosome Assembly Sex-chromosome Dosage Compensation Dosage Compensation By Inactivation Of X Chromosome Positive Regulation Of Keratinocyte Differentiation Nucleosome Organization Protein Heterodimerization Activity Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Regulation Of Keratinocyte Differentiation Protein-DNA Complex Assembly Regulation Of Transcription By RNA Polymerase I Identical Protein Binding Negative Regulation Of Protein Localization To Chromosome, Telomeric Region Regulation Of Epidermal Cell Differentiation ADP-D-ribose Binding Regulation Of NAD Metabolic Process Positive Regulation Of Epithelial Cell Differentiation Regulation Of Epidermis Development Regulation Of RDNA Heterochromatin Formation Positive Regulation Of Endodermal Cell Differentiation Positive Regulation Of Response To Oxidative Stress ADP-D-ribose Modification-dependent Protein Binding Chromatin DNA Binding
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