CRB2 and TP53BP1

Number of citations of the paper that reports this interaction (PMID 17190600)
231

Data Source:
HPRD (in vitro)

		CRB2	TP53BP1
Gene Name		crumbs family member 2	tumor protein p53 binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Protein Complex Membrane Raft Extracellular Vesicular Exosome	Condensed Chromosome Kinetochore Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm
	Molecular Function	Calcium Ion Binding Aspartic-type Endopeptidase Inhibitor Activity Enzyme Binding	RNA Polymerase II Activating Transcription Factor Binding RNA Polymerase II Transcription Cofactor Activity P53 Binding Damaged DNA Binding Protein Binding Methylated Histone Binding Telomeric DNA Binding
	Biological Process	Mesoderm Formation Somitogenesis Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Endopeptidase Activity Notochord Formation Positive Regulation Of BMP Signaling Pathway Maintenance Of Epithelial Cell Apical/basal Polarity Cardiovascular System Development	Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Transcription From RNA Polymerase II Promoter Cellular Response To DNA Damage Stimulus Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Pathways			Homologous Recombination Repair Homologous recombination repair of replication-independent double-strand breaks Recruitment of repair and signaling proteins to double-strand breaks Double-Strand Break Repair
Drugs
Diseases
GWAS
Protein-Protein Interactions		1 interactors: TP53BP1	34 interactors: ARAP1 ATM BLM BRCA1 CCNB1 CDK1 CRB2 DCLRE1A DCLRE1C DYNLL1 E2F1 EP300 GALNTL5 H2AFX HIST1H4A HIST2H4A HIST4H4 IFI16 LIG4 MDC1 MEOX2 NCOA3 NEK1 NFKB1 PAXIP1 PCNT PLK1 RAD18 RELA SPAG9 TFDP1 TP53 USP28 VAC14
Entrez ID		286204	7158
HPRD ID		13093	05569
Ensembl ID		ENSG00000148204	ENSG00000067369
Uniprot IDs		Q5IJ48	F8VY86 Q12888
PDB IDs		2WO6	1GZH 1KZY 1XNI 2G3R 2IG0 2LVM 3LGF 3LGL 3LH0
Enriched GO Terms of Interacting Partners?			Cell Cycle Cellular Response To DNA Damage Stimulus Cellular Response To Stress Response To Ionizing Radiation Mitotic Cell Cycle Cell Cycle Process DNA Damage Checkpoint DNA Metabolic Process Response To Abiotic Stimulus Response To Radiation Mitotic Cell Cycle Process Cell Cycle Checkpoint DNA Repair Nucleobase-containing Compound Metabolic Process Chromosome Organization Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Signal Transduction By P53 Class Mediator Intrinsic Apoptotic Signaling Pathway Cellular Nitrogen Compound Metabolic Process Double-strand Break Repair Response To Stress Organelle Organization Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Nitrogen Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Cellular Response To Stimulus Negative Regulation Of Cellular Metabolic Process Cell Death Telomere Maintenance Death Apoptotic Signaling Pathway DNA Recombination Intracellular Signal Transduction Regulation Of Metabolic Process G2 DNA Damage Checkpoint Chromatin Organization Mitotic Cell Cycle Phase Transition Histone Modification Cell Cycle Phase Transition Apoptotic Process DNA Conformation Change Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Programmed Cell Death DNA Packaging Positive Regulation Of Gene Expression Regulation Of Protein Metabolic Process Positive Regulation Of Metabolic Process G2/M Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process
Tagcloud ?		ablated amaurosis apical compensation crb1 crb3 crbs crumbs degenerative disorganization dystrophy electroretinogram indispensible lamination lca lca8 leber lin maguk mimicking mpp5 mutual pals1 polarity retinal scaffolding uncover validating	abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Difference) ?		ablated amaurosis apical compensation crb1 crb3 crbs crumbs degenerative disorganization dystrophy electroretinogram indispensible lamination lca lca8 leber lin maguk mimicking mpp5 mutual pals1 polarity retinal scaffolding uncover validating	abstract adenocarcinoma bonferroni carcinogenesis cardia cc confirm correction ga gc gca genotype genotypes ldr ligation needed nucleotide p21 p73 polymorphisms remained remaining replication rs1059234 rs3176352 rs560191 rs762623 snps tt
Tagcloud (Intersection) ?