CRB2

Description		crumbs cell polarity complex component 2
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cell Junction Protein-containing Complex Subapical Complex Apical Junction Complex Apical Part Of Cell Extracellular Exosome Anchoring Junction
	Molecular Function	Calcium Ion Binding Protein Binding Aspartic-type Endopeptidase Inhibitor Activity Protein-containing Complex Binding
	Biological Process	Mesoderm Formation Somitogenesis Retina Homeostasis Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Gastrulation Visual Perception Regulation Of Gastrulation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Endopeptidase Activity Notochord Formation Establishment Of Cell Polarity Positive Regulation Of BMP Signaling Pathway Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Photoreceptor Cell Maintenance Retinal Cone Cell Development Ingression Involved In Gastrulation With Mouth Forming Second Circulatory System Development
Pathways
Drugs
Diseases
GWAS		Adult body size ( 32376654) Body mass index ( 25673413 29273807) Brain morphology (MOSTest) ( 32665545)
Interacting Genes		1 interacting genes: TP53BP1
Entrez ID		286204
HPRD ID		13093
Ensembl ID		ENSG00000148204
Uniprot IDs		Q5IJ48
PDB IDs		2WO6
Enriched GO Terms of Interacting Partners?		Cellular Response To X-ray Double-strand Break Repair Via Classical Nonhomologous End Joining Negative Regulation Of DNA Strand Resection Involved In Replication Fork Processing Histone H4K20me Methyltransferase Activity Ubiquitin-modified Histone Reader Activity Histone H4K20me2 Reader Activity Regulation Of DNA Strand Resection Involved In Replication Fork Processing Negative Regulation Of DNA-templated DNA Replication Positive Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA Strand Resection Involved In Replication Fork Processing DNA Repair Complex Replication Fork Negative Regulation Of DNA Replication Telomeric DNA Binding Histone Reader Activity Positive Regulation Of Isotype Switching Response To X-ray Negative Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Localization To Site Of Double-strand Break Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Double-strand Break Repair Negative Regulation Of DNA Repair Negative Regulation Of DNA Recombination Positive Regulation Of Immunoglobulin Production Double-strand Break Repair Via Nonhomologous End Joining Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Damaged DNA Binding P53 Binding Cellular Response To Ionizing Radiation Positive Regulation Of DNA Recombination Regulation Of Immunoglobulin Production Regulation Of Double-strand Break Repair Via Homologous Recombination Positive Regulation Of B Cell Activation Site Of Double-strand Break DNA Damage Checkpoint Signaling Protein Localization To Chromosome Regulation Of DNA Recombination Negative Regulation Of DNA Metabolic Process Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Double-strand Break Repair Regulation Of B Cell Activation Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Transcription Coregulator Activity Response To Ionizing Radiation Regulation Of DNA Replication Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Lymphocyte Mediated Immunity
Tagcloud ?