FAM177A1 and DPM3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		FAM177A1	DPM3
Description		family with sequence similarity 177 member A1	dolichyl-phosphate mannosyltransferase subunit 3, regulatory
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Protein Binding	Protein Binding Enzyme Activator Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity
	Biological Process		Protein Glycosylation Protein O-linked Glycosylation Via Mannose Dolichol Phosphate Mannose Biosynthetic Process
Pathways			Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG Defective DPM3 causes DPM3-CDG Defective DPM2 causes DPM2-CDG
Drugs
Diseases
GWAS		Bipolar disorder lithium response (continuous) or schizophrenia ( 29121268) Blood protein levels ( 30072576) Circulating fibroblast growth factor 23 levels ( 30217807) Colorectal carcinoma in primary sclerosing cholangitis ( 28779025) Hip index ( 34021172) Lymphocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Neutrophil percentage of white cells ( 32888494)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate in non-diabetics ( 31451708) Inflammatory bowel disease ( 28067908) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Prostate cancer ( 23535732) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Urate levels ( 31578528) Urinary albumin-to-creatinine ratio ( 31630189)
Interacting Genes		9 interacting genes: AQP6 DPM3 ELOVL4 FATE1 JAGN1 PBX3 SGPL1 TMX2 TRAF6	6 interacting genes: DPM1 DPM2 FAM177A1 IER3IP1 SEC22B TMEM147
Entrez ID		283635	54344
HPRD ID		12644	16179
Ensembl ID		ENSG00000151327	ENSG00000179085
Uniprot IDs		Q8N128	A0A140VJI4 Q86TM7 Q9P2X0
PDB IDs
Enriched GO Terms of Interacting Partners?		Endoplasmic Reticulum Membrane Endoplasmic Reticulum Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Animal Organ Morphogenesis Membrane Lipid Metabolic Process Nitrate Transmembrane Transporter Activity Posterior Compartment Specification Anterior Compartment Pattern Formation Sphinganine-1-phosphate Aldolase Activity Endoplasmic Reticulum-plasma Membrane Adaptor Activity	Dolichol Phosphate Mannose Biosynthetic Process Dolichol-phosphate-mannose Synthase Complex Endoplasmic Reticulum Membrane Dolichol-linked Oligosaccharide Biosynthetic Process GPI Anchor Metabolic Process Isoprenoid Biosynthetic Process Endoplasmic Reticulum GPI Anchor Biosynthetic Process Glycolipid Biosynthetic Process Dolichyl-phosphate Beta-D-mannosyltransferase Activity Glycolipid Metabolic Process Terpenoid Metabolic Process Isoprenoid Metabolic Process Phosphatidylinositol Biosynthetic Process Alcohol Binding Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Phosphatidylinositol Metabolic Process Protein Glycosylation Macromolecule Glycosylation Protein Localization To Nuclear Inner Membrane Positive Regulation Of Extracellular Matrix Constituent Secretion Glycosylation Glycerophospholipid Biosynthetic Process Membrane Lipid Metabolic Process Phospholipid Biosynthetic Process Glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) Complex Regulation Of Extracellular Matrix Constituent Secretion Glycerophospholipid Metabolic Process Multi-pass Transmembrane Protein Insertion Into ER Membrane Multi-pass Translocon Complex Type B Pancreatic Cell Differentiation Protein O-linked Glycosylation Via Mannose GDP-mannose Metabolic Process Golgi Vesicle Transport Negative Regulation Of Autophagosome Assembly Glycerolipid Metabolic Process Protein Localization To Nuclear Envelope Phospholipid Metabolic Process Enteroendocrine Cell Differentiation Insulin Metabolic Process Establishment Of Protein Localization Regulation Of Fibroblast Apoptotic Process Protein N-linked Glycosylation Via Asparagine D-mannose Binding Positive Regulation Of Extracellular Matrix Organization Enzyme Regulator Activity Carbohydrate Derivative Biosynthetic Process Protein Insertion Into ER Membrane Cellular Localization Lipid Biosynthetic Process
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