NAGA

Name	alpha-N-acetylgalactosaminidase
Structure
Interactors	2 interactors: APP GNGT1
GO Annotations	Cellular Component	Cytoplasm Lysosome Membrane Extracellular Exosome
	Molecular Function	Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-galactosidase Activity Alpha-N-acetylgalactosaminidase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Protein Homodimerization Activity
	Biological Process	Carbohydrate Metabolic Process Lipid Metabolic Process Oligosaccharide Metabolic Process Carbohydrate Catabolic Process Glycoside Catabolic Process Glycolipid Catabolic Process
Drugs	Glycerin
Diseases	Alpha-N-acetylgalactosaminidase deficiency, including: Schindler disease; Kanzaki disease
GWAS	Autism spectrum disorder or schizophrenia ( 28540026 ) Breast size ( 22747683 ) Intelligence ( 28530673 ) Refractive error ( 32231278 ) Schizophrenia ( 25056061 29483656 )
Entrez ID	4668
HPRD ID	00076
Ensembl ID	ENSG00000198951
Uniprot IDs	P17050
PDB IDs	3H53 3H54 3H55 3IGU 4DO4 4DO5 4DO6
GO Terms Enriched among Interactors ?	Acetylcholine Receptor Activator Activity Amyloid-beta Complex PTB Domain Binding Growth Cone Lamellipodium Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Response To Light Stimulus Regulation Of Response To Calcium Ion Amylin Binding Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Endothelin Production Growth Cone Filopodium Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Microglia Development Positive Regulation Of G Protein-coupled Receptor Internalization Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation Cellular Response To Norepinephrine Stimulus Growth Factor Receptor Binding Main Axon Astrocyte Activation Involved In Immune Response Low-density Lipoprotein Particle Mediated Signaling Regulation Of Spontaneous Synaptic Transmission NMDA Selective Glutamate Receptor Signaling Pathway Regulation Of Synapse Structure Or Activity Regulation Of Toll Signaling Pathway Response To Radiation Axon Choice Point Recognition Heparan Sulfate Binding Signaling Receptor Activator Activity Peptidase Activator Activity Cellular Response To Manganese Ion Apoptotic Process Negative Regulation Of Blood Circulation Regulation Of Superoxide Anion Generation Collateral Sprouting Heparan Sulfate Proteoglycan Binding Acetylcholine Receptor Binding Golgi-associated Vesicle Insulin Receptor Binding Apolipoprotein Binding Response To Lead Ion Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel High-density Lipoprotein Particle